Brede meta-analysis


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Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

Number of BipolarsNumber ControlsBipolar MeanBipolar SDControl MeanControls SDPooled SDEffect sizeVariance95% confidenceweightweight *effect sizeweight * effect size^2w^2w starwstar*effect sizeAbstractFirst AuthorYearLink to paperBipolars numberControls, number ofDiagnosisMethodCT basedAge BipolarsSD Age BipolarsAge ControlsSD Age ControlsFemale BPsFemale Ctrls
24227.11.16.30.80.968480534370490.811875599334370.094956946652770.6039756669446810.53108840637778.549933711571176.94148255635101110.9038230229431.596020508531941.29577010691432Entrez-PubMedStrakowski SM1999http://archpsyc.ama-assn.org/cgi/content/full/56/3/2542422DSM-III-RMRI027628679
24183825.96953375639671.7706453842710.658546865466450.102919594450490.628789244533499.716322779342686.398653910196434.2138134757645394.40692835237351.575991937475621.03786455042497Entrez-PubMedAltshuler LL2000ScienceDirect - Biological Psychiatry : An MRI study of temporal lobe structures in men with bipolar disorder or schizophrenia2418DSM-III-RMRI050.212.753.411.100
12125.20.95.90.70.80622577482986-0.838303723430510.184182946146160.84116419676255.42938432099145-4.551473092222383.8155168403038129.47821410502781.3970687959894-1.1711679735665Getz GE, DelBello MP, Fleck DE, Zimmerman ME, Schwiers ML, Strakowski SM.Getz GE2002http://dx.doi.org/10.1016/S0920-9964(01)00210-91212DSM-IVMRI029.28.730.77.543
365618032942137299.3297.250118213228-1.114243168816630.052684306503960.449880019411418.9809844023459-21.149432207728923.5656103618124360.2777688820971.71149141220414-1.9070176145368Entrez PubMedBlumberg HP2003Arch Gen Psychiatry -- Blumberg et al. 60 (12): 12013656DSM-IVMRI03114.128.313.72027
23204.90.85.50.60.7143135883063-0.824507702018090.102180423576770.626527186331559.78661043862911-8.069135683300326.6530645195101195.77774387748421.57782999477029-1.30093298316326Entrez PubMedDelBello MP2004Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder - Bipolar Disorders, Vol 6, Issue 1, pp. 43-52 (Full Text)2320DSM-IVMRI016.32.417.21.999
10816632721925274272.876803704529-0.914419276890950.254735512587120.989238062932623.9256403233452-3.589681185807283.2824736741949415.41065194827381.27171948934982-1.16288481585939Entrez PubMedBlumberg HP2005http://www.blackwell-synergy.com/doi/abs/10.1111/j.1399-5618.2005.00264.x108DSM-IVMRI015415.32.856
20203.930.44.390.450.42573465914816-1.059018610451950.115550754538040.66625804207788.6542057124411-9.164964908154679.705868401874874.89527651324811.54523161973366-1.63642904275675Entrez PubMedChang K (A)2005http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0890-8567&volume=44&issue=6&spage=5652020DSM-IVMRI014.62.814.12.844
43203.330.473.60.590.51041127743335-0.522454495926550.075566673251780.5387921045858313.2333468838591-6.913821575627713.61215716622065175.1214697485421.64699037083668-0.86047752399135Entrez PubMedFrazier JA (A)2005http://ajp.psychiatryonline.org/cgi/content/full/162/7/12564320DSM-IVMRI011.32.7112.6208

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Strakowski SM 1999 7.100000 1.100000 nan 24 6.300000 0.800000 nan 220.968481 0.812 0.308 0.208 1.416 2.635 0.008 10.531088 13.122% 1.596021 12.952%
Altshuler LL 2000 3825.900000 695.000000 nan 24 3375.000000 639.000000 nan 18671.770645 0.659 0.321 0.030 1.287 2.053 0.040 9.716323 12.106% 1.575992 12.790%
Getz GE 2002 5.200000 0.900000 nan 12 5.900000 0.700000 nan 120.806226 -0.838 0.429 -1.679 0.003 -1.953 0.051 5.429384 6.765% 1.397069 11.338%
Blumberg HP 2003 1803.000000 294.000000 nan 36 2137.000000 299.300000 nan 56297.250118 -1.114 0.230 -1.564 -0.664 -4.854 0.000 18.980984 23.650% 1.711491 13.889%
DelBello MP 2004 4.900000 0.800000 nan 23 5.500000 0.600000 nan 200.714314 -0.825 0.320 -1.451 -0.198 -2.579 0.010 9.786610 12.194% 1.577830 12.805%
Blumberg HP 2005 1663.000000 272.000000 nan 10 1925.000000 274.000000 nan 8272.876804 -0.914 0.505 -1.904 0.075 -1.812 0.070 3.925640 4.891% 1.271719 10.320%
Chang K (A) 2005 3.930000 0.400000 nan 20 4.390000 0.450000 nan 200.425735 -1.059 0.340 -1.725 -0.393 -3.115 0.002 8.654206 10.783% 1.545232 12.540%
Frazier JA (A) 2005 3.330000 0.470000 nan 43 3.600000 0.590000 nan 200.510411 -0.522 0.275 -1.061 0.016 -1.901 0.057 13.233347 16.489% 1.646990 13.366%
Meta-analysis (fixed effect) 192 176 -0.480 0.112 -0.698 -0.261 -4.296 0.000 100%
Meta-analysis (random effects, DSL) -0.463 0.285 -1.021 0.095 -1.625 0.104 100%
σa: 0.729110 Q: 43.330996 dof: 7.0 P-value: 0.000

Forest plot

-2 -1 0 1 2 Strakowski SM 0.000000 Altshuler LL 1.000000 Getz GE 2.000000 Blumberg HP 3.000000 DelBello MP 4.000000 Blumberg HP 5.000000 Chang K (A) 6.000000 Frazier JA (A) 7.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.50 -1.00 -1.50 -2.00 0.50 1.00 1.50 2.00 0.20 0.40 0.60 0.80

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.