Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

Number of BipolarsNumber ControlsBipolar MeanBipolar SDControl MeanControls SDPooled SDEffect sizeVariance95% confidenceweightweight *effect sizeweight * effect size^2w^2w starwstar*effect sizeAbstractFirst AuthorYearLink to paperBipolars numberControls, number ofDiagnosisMethodCT basedAge Bipolarssd age bp ttxSD Age BipolarsAge ControlsSD Age ControlsFemale BPsFemale CtrlsBipolars numbers included in meta-analysisControls, numbers included in meta-analysisBipolarBipolar SDControlControl SDBipolarBipolar SDControlsControls SDBipolarsBipolars SDControlsControls SD
21210.000110.0000640.000180.0000746.91809222257119E-005-0.9927483340.10818540550.6446743789.2433909702-9.1763609869.109817080985.44027662774.2190552633-4.1884600836Entrez-PubMedDrevets WC1997Nature2121DSM-III-RMRI0358.2348.2131121210.000110.0000640.000180.0000742199520966
1238298392907770.13439479550.11227509090.10978596280.64942571139.10863260571.02267255360.114820653982.96718794554.19075576160.470517484Entrez-PubMedBrambilla P2002Anatomical MRI Study of Subgenual Prefrontal Cortex in Bipolar and Unipolar Subjects2738DSM-IVMRI035113710121412382983929077330.2100.4313.776.2
6836959.8412.8128.8105.6749260705-0.38802255980.2991498431.07201400963.342806368-1.29708428380.50329796411.17435441362.336534176-0.906627972Entrez PubMedSharma V2003ScienceDirect - Journal of Affective Disorders : An MRI study of subgenual prefrontal cortex in patients with familial and non-familial bipolar I disorder128DSM-III-RMRI038.36.238.36.9646836959.8412.8128.8361.672445.6133.2
1521287.5986.19307.5573.6779.0657588191-0.24683813490.11523594920.66534984988.6778475524-2.14202370510.528733136475.30503814194.0971780095-1.0113397784Entrez PubMedSanches M (A)2005http://dx.doi.org/10.1016/j.pscychresns.2004.11.0041521DSM-IVMRI015.53.516.93.8791521287.5986.19307.5573.67291.4491.81284.9573.33

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Drevets WC 1997 0.000110 0.000064 nan 21 0.000180 0.000074 nan 210.000069 -0.993 0.329 -1.637 -0.348 -3.018 0.003 9.243391 30.433% 4.219055 28.424%
Brambilla P 2002 298.000000 39.000000 nan 12 290.000000 77.000000 nan 3870.134395 0.112 0.331 -0.537 0.762 0.339 0.735 9.108633 29.990% 4.190756 28.233%
Sharma V 2003 369.000000 59.800000 nan 6 412.800000 128.800000 nan 8105.674926 -0.388 0.547 -1.460 0.684 -0.709 0.478 3.342806 11.006% 2.336534 15.741%
Sanches M (A) 2005 287.590000 86.190000 nan 15 307.550000 73.670000 nan 2179.065759 -0.247 0.339 -0.912 0.419 -0.727 0.467 8.677848 28.571% 4.097178 27.602%
Meta-analysis (fixed effect) 54 88 -0.382 0.181 -0.737 -0.026 -2.104 0.035 100%
Meta-analysis (random effects, DSL) -0.380 0.260 -0.888 0.129 -1.463 0.144 100%
σa: 0.358935 Q: 5.831872 dof: 3.0 P-value: 0.120

Forest plot

-2 -1 0 1 2 Drevets WC 0.000000 Brambilla P 1.000000 Sharma V 2.000000 Sanches M (A) 3.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.30 -0.60 -0.90 -1.20 0.30 0.60 0.90 1.20 0.20 0.40 0.60 0.80

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.