Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

AuthorYearStudyPatient meanPatients SDPatients NControls meanControls SDControls NPatient volume percentageP-valueTitle
Fannon20004.62.1144.71.92597.9NSThird ventricle enlargement and developmental delay in first-episode psychosis: Preliminary findings
Fannon20005.82.9374.71.925123.4NSFeatures of structural brain abnormality detected in first-episode psychosis
James19998.123.32295.892.2820137.9<0.02Is the course of brain development in schizophrenia delayed? Evidence from onsets in adolescence
Lawrie19993.72.6203.5230105.7NSMagnetic resonance imaging of brain in people at high risk of developing schizophrenia
Whitworth19984.992.95413.111.6532160.5<0.01Hippocampal volume reduction in male schizophrenic patients
Barr19978.224.22326.522.6942126.1<0.02Brain morphometric comparison of first-episode schizophrenia and temporal lobe epilepsy
DeLisi19916.752.9305.61.720120.5NSBrain morphology in first-episode schizophrenic-like psychotic patients: A quantitative magnetic resonance imaging study
Chua20035.11.7194.41.729115.9NSBrain morphological abnormality in schizophrenia is independent of country of origin
Degreef19928.153.05406.752.125121NSVolumes of ventricular system subdivisions measured from magnetic resonance images in first-episode schizophrenic patients

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Fannon 2000 4.600000 2.100000 nan 14 4.700000 1.900000 nan 251.972582 -0.050 0.334 -0.704 0.605 -0.149 0.882 8.971527 7.555% 8.971527 7.555%
Fannon 2000 5.800000 2.900000 nan 37 4.700000 1.900000 nan 252.547548 0.426 0.262 -0.087 0.940 1.628 0.104 14.578841 12.277% 14.578841 12.277%
James 1999 8.120000 3.320000 nan 29 5.890000 2.280000 nan 202.944150 0.745 0.301 0.155 1.335 2.475 0.013 11.031906 9.290% 11.031906 9.290%
Lawrie 1999 3.700000 2.600000 nan 20 3.500000 2.000000 nan 302.256657 0.087 0.289 -0.479 0.653 0.302 0.763 11.988116 10.095% 11.988116 10.095%
Whitworth 1998 4.990000 2.950000 nan 41 3.110000 1.650000 nan 322.468099 0.754 0.244 0.275 1.233 3.083 0.002 16.735710 14.094% 16.735710 14.094%
Barr 1997 8.220000 4.220000 nan 32 6.520000 2.690000 nan 423.433375 0.490 0.238 0.023 0.957 2.056 0.040 17.614068 14.833% 17.614068 14.833%
DeLisi 1991 6.750000 2.900000 nan 30 5.600000 1.700000 nan 202.494995 0.454 0.293 -0.120 1.027 1.551 0.121 11.686655 9.842% 11.686655 9.842%
Chua 2003 5.100000 1.700000 nan 19 4.400000 1.700000 nan 291.700000 0.405 0.298 -0.180 0.990 1.358 0.175 11.239004 9.465% 11.239004 9.465%
Degreef 1992 8.150000 3.050000 nan 40 6.750000 2.100000 nan 252.727396 0.507 0.259 -0.001 1.015 1.958 0.050 14.901721 12.549% 14.901721 12.549%
Meta-analysis (fixed effect) 262 248 0.452 0.092 0.272 0.632 4.927 0.000 100%
Meta-analysis (random effects, DSL) 0.452 0.092 0.272 0.632 4.927 0.000 100%
σa: 0.000000 Q: 6.429724 dof: 8.0 P-value: 0.599

Forest plot

-2 -1 0 1 2 Fannon 0.000000 Fannon 1.000000 James 2.000000 Lawrie 3.000000 Whitworth 4.000000 Barr 5.000000 DeLisi 6.000000 Chua 7.000000 Degreef 8.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.20 -0.40 -0.60 -0.80 0.20 0.40 0.60 0.80 0.10 0.20 0.30 0.40

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.