Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Sheline YI199820201650310178229654100.0570MRI1.51.259674587
Bremner JD20001616165245513474484337.5100000MRI1.5310618023
Frodl T2003first episode30301944256177629240.356.74024.812MRI1.51.512586453
Frodl T2003multiple episode27271780232174129249.148.137.421.312MRI1.51.512586453
Caetano SC200431311.850.392.020.3739.277.427.911.8000100MRI1.51.515598548
Hastings RS200410101454307171833938.9100.023000100MRI1.51.514997169
Lange C200417171.290.261.120.1734100.029221000MRI1.51.315554576
Xia J200422132349.91125.112323.6937.0639.545.521.45MRI1.51.215641704
Rosso IM200520242.260.3582.520.34315.3585.012.816.55000100MRI1.51.515607296
Weniger G200621231.30.31.10.234100.028231000MRI1.51.316740316
Velakoulis D200612871751396150025622.641.721.5MRI1.51.516461856
Caetano SC200719241.460.221.50.251331.610.34753MRI1.5117949901
Munn MA2007261814516.721653.2214314.911807.4620.54100.015.58MRI1.5117511971
Keller J2008psychosis23112.560.542.650.4836.547.827.630.565177017MRI31.518450931
Keller J2008no-psychosis19112.760.52.650.4836.663.22723.75811042MRI31.518450931
MacMaster FP (B)200832351.490.361.360.2914.0862.511.77000100MRI1.51.517640621
Tamburo RJ200814111295325154732969.835.713.8MRI1.51.519085964
van Eijndhoven P2009depressed20102389236222241234.165.034.121.080MRI1.5119028381
van Eijndhoven P2009remitted20102062300222241235.870.033.43.40MRI1.5119028381
Lorenzetti V (B)2009depressed2915.51606.54170.181564.76145.1935.5275.921.0716MRI1.5119464062
Lorenzetti V (B)2009remitted2715.51666.74201.911564.76145.1935.0766.726.0416MRI1.5119464062
Kronenberg G200924141.710.341.970.2654.562.525.3000MRI1.51.0519394960
Weber K200938620.830.150.830.1366.1181.637.7647MRI30.920018381

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Sheline YI 1998 1650.000000 310.000000 nan 20 1782.000000 296.000000 nan 20303.080847 -0.427 0.320 -1.054 0.201 -1.333 0.182 9.753562 4.189% 3.788922 4.429%
Bremner JD 2000 1652.000000 455.000000 nan 16 1347.000000 448.000000 nan 16451.513566 0.658 0.364 -0.056 1.373 1.807 0.071 7.534311 3.236% 3.399894 3.975%
Frodl T 2003 1944.000000 256.000000 nan 30 1776.000000 292.000000 nan 30274.590604 0.604 0.264 0.086 1.122 2.284 0.022 14.302241 6.143% 4.323020 5.054%
Frodl T 2003 1780.000000 232.000000 nan 27 1741.000000 292.000000 nan 27263.711964 0.146 0.273 -0.388 0.680 0.535 0.593 13.461444 5.782% 4.242917 4.960%
Caetano SC 2004 1.850000 0.390000 nan 31 2.020000 0.370000 nan 310.380132 -0.442 0.257 -0.946 0.063 -1.716 0.086 15.106763 6.489% 4.393747 5.136%
Hastings RS 2004 1454.000000 307.000000 nan 10 1718.000000 339.000000 nan 10323.396042 -0.782 0.468 -1.699 0.135 -1.671 0.095 4.565562 1.961% 2.628592 3.073%
Lange C 2004 1.290000 0.260000 nan 17 1.120000 0.170000 nan 170.219659 0.756 0.357 0.057 1.455 2.119 0.034 7.865052 3.378% 3.465659 4.051%
Xia J 2004 2349.910000 125.110000 nan 22 2323.690000 37.060000 nan 13102.274745 0.250 0.351 -0.438 0.939 0.713 0.476 8.104533 3.481% 3.511379 4.105%
Rosso IM 2005 2.260000 0.358000 nan 20 2.520000 0.343000 nan 240.349865 -0.730 0.314 -1.344 -0.115 -2.328 0.020 10.171474 4.369% 3.850377 4.501%
Weniger G 2006 1.300000 0.300000 nan 21 1.100000 0.200000 nan 230.252605 0.778 0.314 0.162 1.393 2.476 0.013 10.137586 4.354% 3.845511 4.495%
Velakoulis D 2006 1751.000000 396.000000 nan 12 1500.000000 256.000000 nan 87275.476569 0.904 0.315 0.287 1.521 2.872 0.004 10.088087 4.333% 3.838367 4.487%
Caetano SC 2007 1.460000 0.220000 nan 19 1.500000 0.250000 nan 240.237297 -0.165 0.308 -0.768 0.438 -0.538 0.591 10.565385 4.538% 3.905497 4.566%
Munn MA 2007 14516.720000 1653.220000 nan 26 14314.910000 1807.460000 nan 181717.320083 0.115 0.307 -0.486 0.717 0.376 0.707 10.617591 4.560% 3.912608 4.574%
Keller J 2008 2.560000 0.540000 nan 23 2.650000 0.480000 nan 110.521991 -0.168 0.367 -0.888 0.551 -0.458 0.647 7.415167 3.185% 3.375420 3.946%
Keller J 2008 2.760000 0.500000 nan 19 2.650000 0.480000 nan 110.492950 0.217 0.380 -0.528 0.962 0.571 0.568 6.923045 2.974% 3.269622 3.822%
MacMaster FP (B) 2008 1.490000 0.360000 nan 32 1.360000 0.290000 nan 350.325269 0.395 0.247 -0.089 0.879 1.599 0.110 16.377658 7.034% 4.495201 5.255%
Tamburo RJ 2008 1295.000000 325.000000 nan 14 1547.000000 329.000000 nan 11326.745147 -0.746 0.419 -1.567 0.075 -1.780 0.075 5.696583 2.447% 2.967848 3.469%
van Eijndhoven P 2009 2389.000000 236.000000 nan 20 2222.000000 412.000000 nan 10303.898479 0.535 0.394 -0.238 1.308 1.356 0.175 6.431490 2.762% 3.155713 3.689%
van Eijndhoven P 2009 2062.000000 300.000000 nan 20 2222.000000 412.000000 nan 10340.047056 -0.458 0.392 -1.227 0.311 -1.167 0.243 6.492611 2.789% 3.170357 3.706%
Lorenzetti V (B) 2009 1606.540000 170.180000 nan 29 1564.760000 145.190000 nan 16162.087593 0.253 0.316 -0.366 0.872 0.801 0.423 10.021133 4.304% 3.828634 4.476%
Lorenzetti V (B) 2009 1666.740000 201.910000 nan 27 1564.760000 145.190000 nan 16183.627429 0.545 0.325 -0.091 1.181 1.679 0.093 9.487230 4.075% 3.748049 4.382%
Kronenberg G 2009 1.710000 0.340000 nan 24 1.970000 0.260000 nan 140.313475 -0.812 0.350 -1.499 -0.125 -2.317 0.020 8.145003 3.498% 3.518954 4.114%
Weber K 2009 0.830000 0.150000 nan 38 0.830000 0.130000 nan 620.137892 0.000 0.206 -0.404 0.404 0.000 1.000 23.560000 10.119% 4.905676 5.735%
Meta-analysis (fixed effect) 517 535 0.095 0.066 -0.033 0.224 1.456 0.145 100%
Meta-analysis (random effects, DSL) 0.081 0.108 -0.131 0.293 0.746 0.455 100%
σa: 0.401747 Q: 57.674547 dof: 22.0 P-value: 0.000

Forest plot

-2 -1 0 1 2 Sheline YI 0.000000 Bremner JD 1.000000 Frodl T 2.000000 Frodl T 3.000000 Caetano SC 4.000000 Hastings RS 5.000000 Lange C 6.000000 Xia J 7.000000 Rosso IM 8.000000 Weniger G 9.000000 Velakoulis D 10.000000 Caetano SC 11.000000 Munn MA 12.000000 Keller J 13.000000 Keller J 14.000000 MacMaster FP (B) 15.000000 Tamburo RJ 16.000000 van Eijndhoven P 17.000000 van Eijndhoven P 18.000000 Lorenzetti V (B) 19.000000 Lorenzetti V (B) 20.000000 Kronenberg G 21.000000 Weber K 22.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.30 -0.60 -0.90 -1.20 0.30 0.60 0.90 1.20 0.20 0.40 0.60 0.80

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.