Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Sheline YI199820201724304175229554100.05.070.0MRI1.51.259674587
Bremner JD20001616169949313354504337.5100.00.00.00.0MRI1.5310618023
Frodl T2003first episode30301951298181527940.356.74024.812.3MRI1.51.512586453
Frodl T2003multiple episode27271762251181526749.148.137.421.312.3MRI1.51.512586453
Caetano SC200431312.020.472.180.439.277.427.911.80.00.00.0100.0MRI1.51.515598548
Hastings RS200410101411253184522538.9100.023.00.00.00.0100.0MRI1.51.514997169
Lange C200417171.260.261.140.234100.02922.0100.00.0MRI1.51.315554576
Xia J200422132127.32135.982305.5452.2639.545.521.5MRI1.51.215641704
Rosso IM200520242.360.4022.740.39215.3585.012.816.60.00.00.0100.0MRI1.51.515607296
Weniger G200621231.30.31.20.234100.02823.0100.00.0MRI1.51.316740316
Velakoulis D200612871757227151023022.641.721.5MRI1.51.516461856
Caetano SC200719241.560.231.660.281331.610.347.452.6MRI1.5117949901
Munn MA2007261814426.881956.3714262.961747.5120.54100.015.58MRI1.5117511971
Keller J2008psychosis23112.290.452.550.4236.547.827.630.565.217.470.017.4MRI31.518450931
Keller J2008no-psychosis19112.620.532.550.4236.663.22723.757.910.50.042.1MRI31.518450931
MacMaster FP (B)200832351.520.271.360.2914.0862.511.770.00.00.0100.0MRI1.51.517640621
Tamburo RJ200814111433404155329369.835.713.8MRI1.51.519085964
van Eijndhoven P2009depressed20102358307215339634.165.034.121.10.0MRI1.5119028381
van Eijndhoven P2009remitted20102024292215339635.870.033.43.40.0MRI1.5119028381
Lorenzetti V (B)2009depressed2915.51657.09172.291641.36159.5535.5275.921.0716.1MRI1.5119464062
Lorenzetti V (B)2009remitted2715.51642.96186.151641.36159.5535.0766.726.0416.1MRI1.5119464062
Kronenberg G200924141.740.271.970.2854.562.525.30.00.00.0MRI1.51.0519394960
Weber K200938620.840.130.850.1566.1181.637.7647.4MRI30.920018381

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Sheline YI 1998 1724.000000 304.000000 nan 20 1752.000000 295.000000 nan 20299.533804 -0.092 0.316 -0.712 0.529 -0.290 0.772 9.988374 4.331% 2.842891 4.486%
Bremner JD 2000 1699.000000 493.000000 nan 16 1335.000000 450.000000 nan 16471.989936 0.752 0.368 0.031 1.472 2.046 0.041 7.403553 3.210% 2.585927 4.080%
Frodl T 2003 1951.000000 298.000000 nan 30 1815.000000 279.000000 nan 30288.656370 0.465 0.262 -0.048 0.978 1.776 0.076 14.578231 6.321% 3.122720 4.927%
Frodl T 2003 1762.000000 251.000000 nan 27 1815.000000 267.000000 nan 27259.123523 -0.202 0.273 -0.736 0.333 -0.739 0.460 13.426442 5.821% 3.066374 4.838%
Caetano SC 2004 2.020000 0.470000 nan 31 2.180000 0.400000 nan 310.436406 -0.362 0.256 -0.864 0.140 -1.413 0.158 15.233491 6.605% 3.151760 4.973%
Hastings RS 2004 1411.000000 253.000000 nan 10 1845.000000 225.000000 nan 10239.409691 -1.736 0.542 -2.799 -0.674 -3.203 0.001 3.403129 1.475% 1.833229 2.893%
Lange C 2004 1.260000 0.260000 nan 17 1.140000 0.200000 nan 170.231948 0.505 0.349 -0.179 1.189 1.447 0.148 8.204033 3.557% 2.677165 4.224%
Xia J 2004 2127.320000 135.980000 nan 22 2305.540000 52.260000 nan 13112.959507 -1.542 0.401 -2.327 -0.756 -3.846 0.000 6.225300 2.699% 2.425577 3.827%
Rosso IM 2005 2.360000 0.402000 nan 20 2.740000 0.392000 nan 240.396555 -0.941 0.320 -1.569 -0.313 -2.936 0.003 9.735249 4.221% 2.822007 4.453%
Weniger G 2006 1.300000 0.300000 nan 21 1.200000 0.200000 nan 230.252605 0.389 0.305 -0.209 0.986 1.275 0.202 10.754575 4.663% 2.901731 4.579%
Velakoulis D 2006 1757.000000 227.000000 nan 12 1510.000000 230.000000 nan 87229.661764 1.067 0.318 0.445 1.689 3.361 0.001 9.918901 4.301% 2.837235 4.477%
Caetano SC 2007 1.560000 0.230000 nan 19 1.660000 0.280000 nan 240.259239 -0.379 0.310 -0.986 0.229 -1.221 0.222 10.402199 4.510% 2.875450 4.537%
Munn MA 2007 14426.880000 1956.370000 nan 26 14262.960000 1747.510000 nan 181874.636726 0.086 0.307 -0.515 0.687 0.280 0.780 10.625962 4.607% 2.892286 4.564%
Keller J 2008 2.290000 0.450000 nan 23 2.550000 0.420000 nan 110.440844 -0.576 0.374 -1.309 0.157 -1.540 0.124 7.147812 3.099% 2.554010 4.030%
Keller J 2008 2.620000 0.530000 nan 19 2.550000 0.420000 nan 110.493537 0.138 0.379 -0.606 0.882 0.364 0.716 6.948978 3.013% 2.528162 3.989%
MacMaster FP (B) 2008 1.520000 0.270000 nan 32 1.360000 0.290000 nan 350.280639 0.564 0.250 0.074 1.053 2.257 0.024 16.041237 6.955% 3.184941 5.025%
Tamburo RJ 2008 1433.000000 404.000000 nan 14 1553.000000 293.000000 nan 11359.969685 -0.322 0.406 -1.118 0.473 -0.794 0.427 6.067778 2.631% 2.401288 3.789%
van Eijndhoven P 2009 2358.000000 307.000000 nan 20 2153.000000 396.000000 nan 10338.171290 0.590 0.396 -0.186 1.366 1.490 0.136 6.382652 2.767% 2.449102 3.864%
van Eijndhoven P 2009 2024.000000 292.000000 nan 20 2153.000000 396.000000 nan 10329.033216 -0.381 0.391 -1.148 0.385 -0.976 0.329 6.544850 2.838% 2.472615 3.902%
Lorenzetti V (B) 2009 1657.090000 172.290000 nan 29 1641.360000 159.550000 nan 16168.051993 0.092 0.315 -0.525 0.709 0.292 0.770 10.090503 4.375% 2.851104 4.499%
Lorenzetti V (B) 2009 1642.960000 186.150000 nan 27 1641.360000 159.550000 nan 16177.086316 0.009 0.319 -0.616 0.633 0.028 0.978 9.846960 4.269% 2.831318 4.467%
Kronenberg G 2009 1.740000 0.270000 nan 24 1.970000 0.280000 nan 140.273653 -0.823 0.351 -1.510 -0.135 -2.346 0.019 8.127787 3.524% 2.668995 4.211%
Weber K 2009 0.840000 0.130000 nan 38 0.850000 0.150000 nan 620.142779 -0.070 0.206 -0.473 0.334 -0.337 0.736 23.546052 10.209% 3.400110 5.365%
Meta-analysis (fixed effect) 517 535 -0.033 0.066 -0.162 0.096 -0.506 0.613 100%
Meta-analysis (random effects, DSL) -0.083 0.126 -0.329 0.163 -0.663 0.507 100%
σa: 0.501636 Q: 77.067595 dof: 22.0 P-value: 0.000

Forest plot

-2 -1 0 1 2 Sheline YI 0.000000 Bremner JD 1.000000 Frodl T 2.000000 Frodl T 3.000000 Caetano SC 4.000000 Hastings RS 5.000000 Lange C 6.000000 Xia J 7.000000 Rosso IM 8.000000 Weniger G 9.000000 Velakoulis D 10.000000 Caetano SC 11.000000 Munn MA 12.000000 Keller J 13.000000 Keller J 14.000000 MacMaster FP (B) 15.000000 Tamburo RJ 16.000000 van Eijndhoven P 17.000000 van Eijndhoven P 18.000000 Lorenzetti V (B) 19.000000 Lorenzetti V (B) 20.000000 Kronenberg G 21.000000 Weber K 22.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.50 -1.00 -1.50 -2.00 0.50 1.00 1.50 2.00 0.20 0.40 0.60 0.80

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.