Brede meta-analysis


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Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Sheline YI199820203374582.49463523534560.671918354100.0570.0MRI1.51.259674587
Bremner JD20001616167647413414494337.5100.00.00.00.0MRI1.5310618023
Frodl T2003first episode30303895525.7383383591541.713762140.356.74024.812.3MRI1.51.512586453
Frodl T2003multiple episode27273542458.25342333556530.372887749.148.137.421.312.3MRI1.51.512586453
Caetano SC200431313.870.8162597634.20.7305477439.277.427.911.80.00.00.0100.0MRI1.51.515598548
Hastings RS200410102865531.53701663563536.270454238.9100.0230.00.00.0100.0MRI1.51.514997169
Lange C200417172.550.492.260.3334100.02922100.00.0MRI1.51.315554576
Xia J200422134477.23247.71557274629.2384.8726113739.545.521.45MRI1.51.215641704
Rosso IM200520244.620.765.260.73515.3585.012.816.550.00.00.0100.0MRI1.51.515607296
Velakoulis D200612873508593.44098273010461.133386322.641.721.5MRI1.51.516461856
Weniger G200621232.60.5692099792.30.37947331934100.02823100.00.0MRI1.51.316740316
Caetano SC200719243.020.4269191963.160.5028916381331.610.347.452.6MRI1.5117949901
Hickie IB (A)200745163.10.63.40.55266.736.126.864.4MRI1.51.516930719
Munn MA2007261828943.63425.69933928577.873372.59394720.54100.015.58MRI1.5117511971
Andreescu C200871320.220.040.260.0472.269.052.318.316.91.4MRI1.51.518075490
Keller J2008psychosis23114.850.9396275865.20.85402576136.547.827.630.565.217.470.017.4MRI31.518450931
Keller J2008no psychosis19115.380.9771898485.20.85402576136.663.22723.757.910.50.042.1MRI31.518450931
MacMaster FP (B)200832353.010.5983477252.720.55023631314.0862.511.770.00.00.0100.0MRI1.51.517640621
Tamburo RJ200814112728692.04118373100590.190816669.835.713.8MRI1.51.519085964
Kronenberg G200924143.450.5791200223.940.5123280254.562.525.30.00.00.0MRI1.51.0519394960
Lorenzetti V (B)2009depressed2915.53263.63324.89625423206.12289.137409935.5275.921.0716.1MRI1.5119464062
Lorenzetti V (B)2009remitted2715.53309.7368.17977273206.12289.137409935.0766.726.0416.1MRI1.5119464062
van Eijndhoven P2009depressed20104747515.62408794375766.552803134.165.034.121.080.0MRI1.5119028381
van Eijndhoven P2009remitted20104086561.62621024375766.552803135.870.033.43.40.0MRI1.5119028381
Weber K200938621.670.251.680.2766.1181.637.7647.4MRI30.920018381

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Sheline YI 1998 3374.000000 582.494635 nan 20 3534.000000 560.671918 nan 20571.687415 -0.274 0.318 -0.897 0.349 -0.863 0.388 9.896741 3.756% 2.826778 4.054%
Bremner JD 2000 1676.000000 474.000000 nan 16 1341.000000 449.000000 nan 16461.669254 0.707 0.366 -0.010 1.425 1.933 0.053 7.467411 2.834% 2.586442 3.710%
Frodl T 2003 3895.000000 525.738338 nan 30 3591.000000 541.713762 nan 30533.785819 0.562 0.264 0.045 1.079 2.132 0.033 14.391618 5.462% 3.103651 4.451%
Frodl T 2003 3542.000000 458.253423 nan 27 3556.000000 530.372888 nan 27495.626674 -0.028 0.272 -0.561 0.506 -0.102 0.919 13.498590 5.123% 3.059993 4.389%
Caetano SC 2004 3.870000 0.816260 nan 31 4.200000 0.730548 nan 310.774590 -0.421 0.257 -0.924 0.083 -1.637 0.102 15.142292 5.747% 3.137191 4.499%
Hastings RS 2004 2865.000000 531.537017 nan 10 3563.000000 536.270454 nan 10533.908981 -1.252 0.499 -2.230 -0.274 -2.510 0.012 4.019143 1.525% 1.993916 2.860%
Lange C 2004 2.550000 0.490000 nan 17 2.260000 0.330000 nan 170.417732 0.678 0.354 -0.016 1.372 1.915 0.055 7.981531 3.029% 2.645464 3.794%
Xia J 2004 4477.230000 247.715573 nan 22 4629.230000 84.872611 nan 13204.128853 -0.728 0.362 -1.437 -0.018 -2.011 0.044 7.639461 2.900% 2.606776 3.739%
Rosso IM 2005 4.620000 0.760000 nan 20 5.260000 0.735000 nan 240.746413 -0.842 0.317 -1.463 -0.221 -2.656 0.008 9.948656 3.776% 2.830997 4.060%
Velakoulis D 2006 3508.000000 593.440983 nan 12 3010.000000 461.133386 nan 87477.981993 1.034 0.317 0.413 1.655 3.262 0.001 9.955297 3.779% 2.831535 4.061%
Weniger G 2006 2.600000 0.569210 nan 21 2.300000 0.379473 nan 230.479285 0.615 0.310 0.008 1.221 1.986 0.047 10.436970 3.961% 2.869197 4.115%
Caetano SC 2007 3.020000 0.426919 nan 19 3.160000 0.502892 nan 240.471049 -0.292 0.309 -0.897 0.314 -0.945 0.345 10.483527 3.979% 2.872704 4.120%
Hickie IB (A) 2007 3.100000 0.600000 nan 45 3.400000 0.500000 nan 160.576224 -0.514 0.295 -1.092 0.064 -1.742 0.081 11.489346 4.361% 2.943311 4.221%
Munn MA 2007 28943.600000 3425.699339 nan 26 28577.870000 3372.593947 nan 183404.304096 0.106 0.307 -0.496 0.707 0.344 0.731 10.620670 4.031% 2.882905 4.135%
Andreescu C 2008 0.220000 0.040000 nan 71 0.260000 0.040000 nan 320.040000 -0.993 0.224 -1.432 -0.553 -4.425 0.000 19.877916 7.545% 3.300075 4.733%
Keller J 2008 4.850000 0.939628 nan 23 5.200000 0.854026 nan 110.913739 -0.374 0.370 -1.099 0.351 -1.011 0.312 7.314546 2.776% 2.567854 3.683%
Keller J 2008 5.380000 0.977190 nan 19 5.200000 0.854026 nan 110.935067 0.187 0.380 -0.557 0.932 0.493 0.622 6.934152 2.632% 2.519336 3.613%
MacMaster FP (B) 2008 3.010000 0.598348 nan 32 2.720000 0.550236 nan 350.573685 0.500 0.249 0.012 0.987 2.010 0.044 16.180999 6.141% 3.179477 4.560%
Tamburo RJ 2008 2728.000000 692.041184 nan 14 3100.000000 590.190817 nan 11649.723185 -0.554 0.412 -1.361 0.254 -1.344 0.179 5.895675 2.238% 2.367805 3.396%
Kronenberg G 2009 3.450000 0.579120 nan 24 3.940000 0.512328 nan 140.555927 -0.863 0.352 -1.553 -0.173 -2.450 0.014 8.062800 3.060% 2.654332 3.807%
Lorenzetti V (B) 2009 3263.630000 324.896254 nan 29 3206.120000 289.137410 nan 16313.155422 0.180 0.315 -0.438 0.798 0.572 0.567 10.060361 3.818% 2.839971 4.073%
Lorenzetti V (B) 2009 3309.700000 368.179773 nan 27 3206.120000 289.137410 nan 16341.986621 0.297 0.320 -0.331 0.925 0.928 0.354 9.737216 3.696% 2.813612 4.035%
van Eijndhoven P 2009 4747.000000 515.624088 nan 20 4375.000000 766.552803 nan 10607.686614 0.596 0.396 -0.181 1.372 1.504 0.133 6.377287 2.420% 2.441866 3.502%
van Eijndhoven P 2009 4086.000000 561.626210 nan 20 4375.000000 766.552803 nan 10634.752055 -0.443 0.392 -1.212 0.326 -1.130 0.259 6.503423 2.468% 2.460137 3.528%
Weber K 2009 1.670000 0.250000 nan 38 1.680000 0.270000 nan 620.262628 -0.038 0.206 -0.442 0.366 -0.183 0.854 23.555876 8.941% 3.387895 4.859%
Meta-analysis (fixed effect) 633 583 -0.073 0.062 -0.194 0.047 -1.192 0.233 100%
Meta-analysis (random effects, DSL) -0.074 0.120 -0.308 0.161 -0.615 0.538 100%
σa: 0.502709 Q: 87.452357 dof: 24.0 P-value: 0.000

Forest plot

-2 -1 0 1 2 Sheline YI 0.000000 Bremner JD 1.000000 Frodl T 2.000000 Frodl T 3.000000 Caetano SC 4.000000 Hastings RS 5.000000 Lange C 6.000000 Xia J 7.000000 Rosso IM 8.000000 Velakoulis D 9.000000 Weniger G 10.000000 Caetano SC 11.000000 Hickie IB (A) 12.000000 Munn MA 13.000000 Andreescu C 14.000000 Keller J 15.000000 Keller J 16.000000 MacMaster FP (B) 17.000000 Tamburo RJ 18.000000 Kronenberg G 19.000000 Lorenzetti V (B) 20.000000 Lorenzetti V (B) 21.000000 van Eijndhoven P 22.000000 van Eijndhoven P 23.000000 Weber K 24.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.50 -1.00 -1.50 -2.00 0.50 1.00 1.50 2.00 0.20 0.40 0.60 0.80

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.