Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Bremner JD2002152063171114683721184333.3100.0MRI1.5311958777
Caetano SC200631314.930.8634465825.870.99612248239.277.427.911.80.00.00.0100.0MRI1.51.516414029
Lavretsky H200743410.00870.0028467530.00870.00161554970.6776.749.617.70.00.00.0100.0MRI1.51.417463189
Andreescu C200871321.850.271.970.3472.269.052.318.316.91.4MRI1.51.518075490
Frodl T (A)2008787813.222.87513825812.873.16936586744.751.339.623.511.510.310.3MRI1.51.518406580
Weber K200938622.720.622.630.6366.1181.637.7647.4MRI30.920018381

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Bremner JD 2002 6317.000000 1114.000000 nan 15 6837.000000 2118.000000 nan 201763.317294 -0.288 0.344 -0.961 0.385 -0.839 0.402 8.474344 6.660% 4.318337 12.087%
Caetano SC 2006 4.930000 0.863447 nan 31 5.870000 0.996122 nan 310.932148 -0.996 0.270 -1.526 -0.466 -3.684 0.000 13.688293 10.757% 5.358410 14.998%
Lavretsky H 2007 0.008700 0.002847 nan 43 0.008700 0.001616 nan 410.002329 0.000 0.218 -0.428 0.428 0.000 1.000 20.988095 16.494% 6.202956 17.362%
Andreescu C 2008 1.850000 0.270000 nan 71 1.970000 0.340000 nan 320.293268 -0.406 0.215 -0.827 0.015 -1.890 0.059 21.660462 17.022% 6.260389 17.523%
Frodl T (A) 2008 13.220000 2.875138 nan 78 12.870000 3.169366 nan 783.025830 0.115 0.160 -0.199 0.429 0.718 0.473 38.933847 30.597% 7.181225 20.100%
Weber K 2009 2.720000 0.620000 nan 38 2.630000 0.630000 nan 620.626243 0.143 0.206 -0.262 0.547 0.691 0.489 23.501386 18.469% 6.405408 17.929%
Meta-analysis (fixed effect) 276 264 -0.134 0.089 -0.308 0.040 -1.510 0.131 100%
Meta-analysis (random effects, DSL) -0.207 0.167 -0.535 0.121 -1.235 0.217 100%
σa: 0.336998 Q: 16.562008 dof: 5.0 P-value: 0.005

Forest plot

-2 -1 0 1 2 Bremner JD 0.000000 Caetano SC 1.000000 Lavretsky H 2.000000 Andreescu C 3.000000 Frodl T (A) 4.000000 Weber K 5.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.30 -0.60 -0.90 -1.20 0.30 0.60 0.90 1.20 0.10 0.20 0.30 0.40

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.