Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Wu JC199320162.290.631.860.3432.955.022.3000100MRI1.558326077
Lacerda AL200522391.140.221.140.2641.486.4000100MRI1.5315804385
Ballmaier M (B)20084634258.8952.4312.89554.05073.951.4317.73000100MRI1.51.417712348
Sun J200945300.130.020.140.03051.126.168218MRI1.51.519486330

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Wu JC 1993 2.290000 0.630000 nan 20 1.860000 0.340000 nan 160.522300 0.805 0.350 0.119 1.491 2.299 0.022 8.156200 14.271% 1.886472 22.785%
Lacerda AL 2005 1.140000 0.220000 nan 22 1.140000 0.260000 nan 390.246508 0.000 0.267 -0.523 0.523 0.000 1.000 14.065574 24.611% 2.089517 25.238%
Ballmaier M (B) 2008 258.890000 52.400000 nan 46 312.895000 54.050000 nan 3453.104334 -1.007 0.240 -1.478 -0.536 -4.189 0.000 17.295353 30.262% 2.149137 25.958%
Sun J 2009 0.130000 0.020000 nan 45 0.140000 0.030000 nan 300.024467 -0.405 0.238 -0.871 0.062 -1.699 0.089 17.634555 30.856% 2.154286 26.020%
Meta-analysis (fixed effect) 133 119 -0.315 0.132 -0.574 -0.055 -2.379 0.017 100%
Meta-analysis (random effects, DSL) -0.183 0.348 -0.864 0.498 -0.527 0.598 100%
σa: 0.638345 Q: 20.053534 dof: 3.0 P-value: 0.000

Forest plot

-2 -1 0 1 2 Wu JC 0.000000 Lacerda AL 1.000000 Ballmaier M (B) 2.000000 Sun J 3.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.50 -1.00 -1.50 -2.00 0.50 1.00 1.50 2.00 0.10 0.20 0.30 0.40

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.