Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Pantel J19971913835.992882.68672.478.964.226.7MRI1.51.259089060
Parashos IA199872381027.03102.891059.89144.7355.462.538.5MRI1.559870413
Ashtari M199940461267126124913874.370.061.526.1MRI13.110405084
Kumar A (A)20005130942127.41008.65128.6974.370.619.8MRI1.5510693154
McIntosh AM2001929126701268616132666410803543.5655.6MRI11.8811200955
Bremner JD20021520126603514494212333331520984333.3100MRI1.5311958777
Frodl T (A)200230301265.9891274.7132.140.356.74024.887MRI1.51.511983184
Pujol J200257371157107110912160.859.65028.8MRI1.52.311771978
Steingard RJ200219381312122138211715.484.217.30100MRI1.51.512242057
Posener JA2003274210027331300319927891058303355.627.3MRI1.5112505805
Janssen J20042841980.7187.91965.01107.0264.04100.033.0461251421MRI1.51.215576058
Lange C2004171711369711329334100.029221000MRI1.51.315554576
Lloyd AJ20045139962.796.7968.982.97480.457MRI1115172942
Vythilingam M20043833119440713145712394751208214160.5039MRI1.51.515231442
Weniger G200621231164110112510834100.028231000MRI1.51.316740316
Velakoulis D20061287127008892578136053313984522.641.721.5MRI1.51.516461856
Caetano SC200719241282125.871248.51124.821331.610.34753MRI1.5117949901
Maller JJ2007males22131.2570.08581.2270.129437.290.0MRI1.50.9417604352
Maller JJ2007females23171.130.09811.1920.096737.47100.0MRI1.50.9417604352
Taylor WD20072261441149.2134.41138.8119.97066.445.4MRI1.5317335636
Ballmaier M (B)200846341295.68129.611286.93138.7271.173.951.4317.73000100MRI1.51.417712348
Lenze SN200831241018148100510950100.029777MRI1.51.2518068956
Matsuo K200827261205.9139.41183.5120.214.463.011.75000100MRI1.51.518439110
Andreescu C20087132518236.0363063.89515438.4461121.1272.269.052.318.3171MRI1.51.518075490
Lorenzetti V2009depressed3116.51237176124113.14781250567141214.816432.5271.021.07MRI1.5119239986
Lorenzetti V2009remitted3116.51232334132954.97721250567141214.816435.0758.126.04MRI1.5119239986
van Eijndhoven P2009depressed2010117110612149934.165.034.121.080MRI1.5119028381
van Eijndhoven P2009remitted2010120311212149935.870.033.43.40MRI1.5119028381
Kronenberg G200924141057.596.11096.7113.554.562.525.3000MRI1.51.0519394960
Exner C2009melancholic2613120713012121313576.929.722.186MRI1.51.319345999
Exner C2009non-Melancholic913123312712121313344.430.316.386MRI1.51.319345999
Kaymak SU20092015877.3254.54889.2645.5132100.023.1000100MRI3119756819
Köhler S20103529965819698874.180.0800MRI1120118461

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Pantel J 1997 835.900000 92.000000 nan 19 882.600000 86.000000 nan 1389.648201 -0.508 0.366 -1.226 0.210 -1.386 0.166 7.454379 1.480% 6.935092 1.699%
Parashos IA 1998 1027.030000 102.890000 nan 72 1059.890000 144.730000 nan 38118.893883 -0.274 0.201 -0.669 0.120 -1.363 0.173 24.654959 4.893% 19.761026 4.842%
Ashtari M 1999 1267.000000 126.000000 nan 40 1249.000000 138.000000 nan 46132.563731 0.135 0.216 -0.290 0.559 0.622 0.534 21.344960 4.236% 17.576442 4.307%
Kumar A (A) 2000 942.000000 127.400000 nan 51 1008.650000 128.690000 nan 30127.875056 -0.516 0.234 -0.975 -0.058 -2.208 0.027 18.291425 3.630% 15.452298 3.786%
McIntosh AM 2001 1267012.000000 68616.000000 nan 9 1326664.000000 108035.000000 nan 29100618.774196 -0.580 0.388 -1.341 0.180 -1.496 0.135 6.642785 1.318% 6.227265 1.526%
Bremner JD 2002 1266035.000000 144942.000000 nan 15 1233333.000000 152098.000000 nan 20149104.071604 0.214 0.343 -0.457 0.886 0.625 0.532 8.517455 1.690% 7.846163 1.923%
Frodl T (A) 2002 1265.900000 89.000000 nan 30 1274.700000 132.100000 nan 30112.630835 -0.077 0.258 -0.583 0.429 -0.299 0.765 14.988075 2.975% 13.026842 3.192%
Pujol J 2002 1157.000000 107.000000 nan 57 1109.000000 121.000000 nan 37112.685596 0.422 0.213 0.004 0.841 1.979 0.048 21.948190 4.356% 17.983441 4.407%
Steingard RJ 2002 1312.000000 122.000000 nan 19 1382.000000 117.000000 nan 38118.659559 -0.582 0.287 -1.144 -0.020 -2.030 0.042 12.174703 2.416% 10.848058 2.658%
Posener JA 2003 1002733.000000 130031.000000 nan 27 992789.000000 105830.000000 nan 42115823.407134 0.085 0.247 -0.399 0.569 0.344 0.731 16.419837 3.259% 14.095066 3.454%
Janssen J 2004 980.710000 87.910000 nan 28 965.010000 107.020000 nan 4199.760291 0.156 0.246 -0.326 0.637 0.634 0.526 16.586328 3.292% 14.217574 3.484%
Lange C 2004 1136.000000 97.000000 nan 17 1132.000000 93.000000 nan 1795.021050 0.041 0.343 -0.631 0.713 0.120 0.905 8.497970 1.687% 7.829626 1.919%
Lloyd AJ 2004 962.700000 96.700000 nan 51 968.900000 82.900000 nan 3990.998007 -0.068 0.213 -0.485 0.349 -0.317 0.751 22.087059 4.384% 18.076564 4.429%
Vythilingam M 2004 1194407.000000 131457.000000 nan 38 1239475.000000 120821.000000 nan 33126635.488233 -0.352 0.240 -0.822 0.118 -1.467 0.142 17.378406 3.449% 14.795626 3.625%
Weniger G 2006 1164.000000 110.000000 nan 21 1125.000000 108.000000 nan 23108.956960 0.352 0.304 -0.245 0.948 1.155 0.248 10.794534 2.142% 9.738582 2.386%
Velakoulis D 2006 1270088.000000 92578.000000 nan 12 1360533.000000 139845.000000 nan 87135317.389906 -0.663 0.312 -1.274 -0.052 -2.128 0.033 10.294302 2.043% 9.329578 2.286%
Caetano SC 2007 1282.000000 125.870000 nan 19 1248.510000 124.820000 nan 24125.282059 0.262 0.309 -0.342 0.867 0.851 0.395 10.506452 2.085% 9.503492 2.329%
Maller JJ 2007 1.257000 0.085800 nan 22 1.227000 0.129400 nan 130.103796 0.282 0.352 -0.407 0.972 0.803 0.422 8.086590 1.605% 7.479074 1.833%
Maller JJ 2007 1.130000 0.098100 nan 23 1.192000 0.096700 nan 170.097513 -0.623 0.328 -1.266 0.020 -1.899 0.058 9.286204 1.843% 8.493904 2.081%
Taylor WD 2007 1149.200000 134.400000 nan 226 1138.800000 119.900000 nan 144128.959311 0.080 0.107 -0.129 0.290 0.755 0.451 87.888365 17.444% 46.678938 11.438%
Ballmaier M (B) 2008 1295.680000 129.610000 nan 46 1286.930000 138.720000 nan 34133.540098 0.065 0.226 -0.379 0.508 0.287 0.774 19.539426 3.878% 16.333612 4.002%
Lenze SN 2008 1018.000000 148.000000 nan 31 1005.000000 109.000000 nan 24132.493004 0.097 0.272 -0.437 0.630 0.356 0.722 13.510530 2.681% 11.896093 2.915%
Matsuo K 2008 1205.900000 139.400000 nan 27 1183.500000 120.200000 nan 26130.342111 0.169 0.275 -0.370 0.709 0.615 0.539 13.194223 2.619% 11.650176 2.855%
Andreescu C 2008 518236.030000 63063.890000 nan 71 515438.440000 61121.120000 nan 3262474.020434 0.044 0.213 -0.373 0.462 0.209 0.835 22.053402 4.377% 18.054013 4.424%
Lorenzetti V 2009 1237176.000000 124113.147800 nan 31 1250567.000000 141214.816400 nan 16130191.522610 -0.101 0.305 -0.699 0.497 -0.332 0.740 10.754820 2.135% 9.706247 2.378%
Lorenzetti V 2009 1232334.000000 132954.977200 nan 31 1250567.000000 141214.816400 nan 16135825.191194 -0.132 0.305 -0.730 0.466 -0.433 0.665 10.745274 2.133% 9.698471 2.376%
van Eijndhoven P 2009 1171.000000 106.000000 nan 20 1214.000000 99.000000 nan 10103.801493 -0.403 0.391 -1.170 0.364 -1.030 0.303 6.530956 1.296% 6.128886 1.502%
van Eijndhoven P 2009 1203.000000 112.000000 nan 20 1214.000000 99.000000 nan 10107.992229 -0.099 0.388 -0.859 0.660 -0.256 0.798 6.658302 1.322% 6.240899 1.529%
Kronenberg G 2009 1057.500000 96.100000 nan 24 1096.700000 113.500000 nan 14102.723886 -0.374 0.339 -1.039 0.291 -1.101 0.271 8.684761 1.724% 7.987917 1.957%
Exner C 2009 1207.000000 130.000000 nan 26 1212.000000 131.000000 nan 13130.325165 -0.038 0.340 -0.703 0.628 -0.111 0.912 8.665154 1.720% 7.971327 1.953%
Exner C 2009 1233.000000 127.000000 nan 9 1212.000000 131.000000 nan 13129.414837 0.156 0.434 -0.695 1.008 0.359 0.719 5.299168 1.052% 5.031352 1.233%
Kaymak SU 2009 877.320000 54.540000 nan 20 889.260000 45.510000 nan 1550.905099 -0.229 0.343 -0.901 0.443 -0.669 0.504 8.509755 1.689% 7.839628 1.921%
Köhler S 2010 965.000000 81.000000 nan 35 969.000000 88.000000 nan 2984.233355 -0.047 0.251 -0.539 0.445 -0.187 0.852 15.854769 3.147% 13.676640 3.351%
Meta-analysis (fixed effect) 1187 1014 -0.047 0.045 -0.134 0.041 -1.050 0.294 100%
Meta-analysis (random effects, DSL) -0.059 0.050 -0.156 0.038 -1.183 0.237 100%
σa: 0.100224 Q: 36.780220 dof: 32.0 P-value: 0.257

Forest plot

-2 -1 0 1 2 Pantel J 0.000000 Parashos IA 1.000000 Ashtari M 2.000000 Kumar A (A) 3.000000 McIntosh AM 4.000000 Bremner JD 5.000000 Frodl T (A) 6.000000 Pujol J 7.000000 Steingard RJ 8.000000 Posener JA 9.000000 Janssen J 10.000000 Lange C 11.000000 Lloyd AJ 12.000000 Vythilingam M 13.000000 Weniger G 14.000000 Velakoulis D 15.000000 Caetano SC 16.000000 Maller JJ 17.000000 Maller JJ 18.000000 Taylor WD 19.000000 Ballmaier M (B) 20.000000 Lenze SN 21.000000 Matsuo K 22.000000 Andreescu C 23.000000 Lorenzetti V 24.000000 Lorenzetti V 25.000000 van Eijndhoven P 26.000000 van Eijndhoven P 27.000000 Kronenberg G 28.000000 Exner C 29.000000 Exner C 30.000000 Kaymak SU 31.000000 Köhler S 32.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.20 -0.40 -0.60 -0.80 0.20 0.40 0.60 0.80 0.20 0.40 0.60 0.80

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.