Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Pillay SS199838204.40.74.40.438.555.320.6MRI1.5310710164
Lenze EJ (B)199924243.380.633.210.5753100.0MRI1.2510588417
Bremner JD20001616271276528026134337.5100.00.00.00.0MRI1.5310618023
McIntosh AM20019294126449422151343.5655.6MRI11.8811200955
Lacerda AL200325482.360.542.460.5641.216.029.4410.90.00.00.0100.0MRI1.5514623065
Hannestad J2006182643.650.63.630.670.270.943.7MRI1.5316955447
Matsuo K200827262.370.312.560.3414.463.011.750.00.00.0100.0MRI1.51.518439110
Pizzagalli DA200926313645516359252043.1757.729.3916.00.00.00.0100.0MRI1.51.3319411368

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Pillay SS 1998 4.400000 0.700000 nan 38 4.400000 0.400000 nan 200.614846 0.000 0.276 -0.541 0.541 0.000 1.000 13.103448 10.055% 13.103448 10.055%
Lenze EJ (B) 1999 3.380000 0.630000 nan 24 3.210000 0.570000 nan 240.600750 0.278 0.290 -0.290 0.847 0.959 0.337 11.874719 9.112% 11.874719 9.112%
Bremner JD 2000 2712.000000 765.000000 nan 16 2802.000000 613.000000 nan 16693.178909 -0.127 0.354 -0.820 0.567 -0.358 0.721 7.981774 6.125% 7.981774 6.125%
McIntosh AM 2001 4126.000000 449.000000 nan 9 4221.000000 513.000000 nan 29499.486959 -0.186 0.382 -0.935 0.563 -0.487 0.626 6.844493 5.252% 6.844493 5.252%
Lacerda AL 2003 2.360000 0.540000 nan 25 2.460000 0.560000 nan 480.553320 -0.179 0.247 -0.663 0.306 -0.724 0.469 16.376040 12.566% 16.376040 12.566%
Hannestad J 2006 3.650000 0.600000 nan 182 3.630000 0.600000 nan 640.600000 0.033 0.145 -0.252 0.318 0.229 0.819 47.344480 36.328% 47.344480 36.328%
Matsuo K 2008 2.370000 0.310000 nan 27 2.560000 0.340000 nan 260.325052 -0.576 0.281 -1.126 -0.025 -2.050 0.040 12.677720 9.728% 12.677720 9.728%
Pizzagalli DA 2009 3645.000000 516.000000 nan 26 3592.000000 520.000000 nan 31518.185646 0.101 0.266 -0.421 0.622 0.379 0.705 14.121202 10.835% 14.121202 10.835%
Meta-analysis (fixed effect) 347 258 -0.048 0.088 -0.219 0.124 -0.544 0.586 100%
Meta-analysis (random effects, DSL) -0.048 0.088 -0.219 0.124 -0.544 0.586 100%
σa: 0.000000 Q: 5.913214 dof: 7.0 P-value: 0.550

Forest plot

-2 -1 0 1 2 Pillay SS 0.000000 Lenze EJ (B) 1.000000 Bremner JD 2.000000 McIntosh AM 3.000000 Lacerda AL 4.000000 Hannestad J 5.000000 Matsuo K 6.000000 Pizzagalli DA 7.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.20 -0.40 -0.60 -0.80 0.20 0.40 0.60 0.80 0.10 0.20 0.30 0.40

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.