Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Lisanby SH199321215.471.246.341.656542.9MRI1.558294897
Dupont RM (A)199530261719.17245.11806.35243.7338.670.012.540.03.30.056.7MRI1.557654126
Parashos IA199872383.810.864.420.8855.462.538.5MRI1.559870413
Pillay SS1998382091.32815661790.95078914638.555.320.6MRI1.5310710164
Lenze EJ (B)199924246.721.2524056856.41.100490853100.0MRI1.2510588417
Bremner JD2000161653801399.4159555691123.3195454337.5100.00.00.00.0MRI1.5310618023
McIntosh AM20019298393906.1718388557910.97508243.5655.6MRI11.8811200955
Lacerda AL200325484.990.9115261935.281.00578327741.216.029.4410.90.00.00.0100.0MRI1.5514623065
Hannestad J2006182647.141.37.111.170.270.943.7MRI1.5316955447
Hickie IB (A)200745165.90.96.20.95266.736.126.864.4MRI1.51.516930719
Andreescu C200871320.890.180.930.1972.269.052.318.316.91.4MRI1.51.518075490
Matsuo K200827264.790.607190255.090.62616291814.463.011.750.00.00.0100.0MRI1.51.518439110
Pizzagalli DA200926317072970.5071877025917.66715143.1757.729.3916.00.00.00.0100.0MRI1.51.3319411368

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Lisanby SH 1993 5.470000 1.240000 nan 21 6.340000 1.650000 nan 211.459469 -0.585 0.316 -1.204 0.034 -1.852 0.064 10.026892 4.746% 8.500515 5.488%
Dupont RM (A) 1995 1719.170000 245.100000 nan 30 1806.350000 243.730000 nan 26244.466695 -0.352 0.270 -0.881 0.178 -1.302 0.193 13.701928 6.485% 11.002243 7.103%
Parashos IA 1998 3.810000 0.860000 nan 72 4.420000 0.880000 nan 380.866904 -0.699 0.206 -1.103 -0.295 -3.389 0.001 23.525821 11.135% 16.552286 10.686%
Pillay SS 1998 9.000000 1.328157 nan 38 9.000000 0.950789 nan 201.213348 0.000 0.276 -0.541 0.541 0.000 1.000 13.103448 6.202% 10.613016 6.852%
Lenze EJ (B) 1999 6.720000 1.252406 nan 24 6.400000 1.100491 nan 241.178898 0.267 0.290 -0.302 0.836 0.920 0.357 11.884633 5.625% 9.799079 6.326%
Bremner JD 2000 5380.000000 1399.415950 nan 16 5569.000000 1123.319545 nan 161268.899484 -0.145 0.354 -0.839 0.549 -0.410 0.682 7.976031 3.775% 6.979157 4.506%
McIntosh AM 2001 8393.000000 906.171838 nan 9 8557.000000 910.975082 nan 29909.909886 -0.176 0.382 -0.926 0.573 -0.462 0.644 6.846925 3.241% 6.099082 3.937%
Lacerda AL 2003 4.990000 0.911526 nan 25 5.280000 1.005783 nan 480.974942 -0.294 0.248 -0.780 0.192 -1.187 0.235 16.270635 7.701% 12.599450 8.134%
Hannestad J 2006 7.140000 1.300000 nan 182 7.110000 1.100000 nan 641.251425 0.024 0.145 -0.261 0.309 0.164 0.869 47.346949 22.409% 25.622095 16.541%
Hickie IB (A) 2007 5.900000 0.900000 nan 45 6.200000 0.900000 nan 160.900000 -0.329 0.293 -0.903 0.245 -1.124 0.261 11.672540 5.525% 9.654440 6.233%
Andreescu C 2008 0.890000 0.180000 nan 71 0.930000 0.190000 nan 320.183127 -0.217 0.213 -0.635 0.202 -1.016 0.310 21.943418 10.386% 15.753023 10.170%
Matsuo K 2008 4.790000 0.607190 nan 27 5.090000 0.626163 nan 260.616564 -0.479 0.279 -1.026 0.067 -1.718 0.086 12.846761 6.080% 10.443999 6.742%
Pizzagalli DA 2009 7072.000000 970.507187 nan 26 7025.000000 917.667151 nan 31942.052836 0.049 0.266 -0.472 0.571 0.185 0.853 14.135790 6.690% 11.280246 7.282%
Meta-analysis (fixed effect) 586 391 -0.208 0.069 -0.343 -0.074 -3.029 0.002 100%
Meta-analysis (random effects, DSL) -0.220 0.080 -0.377 -0.062 -2.733 0.006 100%
σa: 0.133821 Q: 15.380691 dof: 12.0 P-value: 0.221

Forest plot

-2 -1 0 1 2 Lisanby SH 0.000000 Dupont RM (A) 1.000000 Parashos IA 2.000000 Pillay SS 3.000000 Lenze EJ (B) 4.000000 Bremner JD 5.000000 McIntosh AM 6.000000 Lacerda AL 7.000000 Hannestad J 8.000000 Hickie IB (A) 9.000000 Andreescu C 10.000000 Matsuo K 11.000000 Pizzagalli DA 12.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.20 -0.40 -0.60 -0.80 0.20 0.40 0.60 0.80 0.10 0.20 0.30 0.40

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.