Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Krishnan KR1992505090714296315648.354.0MRI1.551627046
Dupont RM (A)19953026192060.6719334.8193525.6515901.3738.670.012.5403057MRI1.557654126
Pillay SS199738201071.3142.41052.9106.538.555.3MRI1.539209723
Botteron KN200248481038225109774100.015.2MRI1.5111958786
Sheline YI200338381057152105415450.8100.06.7MRI1.512900317
Hastings RS200418181.430.141.40.2738.955.623000100MRI1.51.514997169
Pan CC2009170831156.4130.81163.6123.369.465.9MRI1.5319235787

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Krishnan KR 1992 907.000000 142.000000 nan 50 963.000000 156.000000 nan 50149.164339 -0.373 0.202 -0.768 0.023 -1.846 0.065 24.556504 15.454% 24.556504 15.454%
Dupont RM (A) 1995 192060.670000 19334.800000 nan 30 193525.650000 15901.370000 nan 2617827.641582 -0.081 0.268 -0.606 0.444 -0.302 0.762 13.916349 8.758% 13.916349 8.758%
Pillay SS 1997 1071.300000 142.400000 nan 38 1052.900000 106.500000 nan 20131.324290 0.138 0.277 -0.404 0.680 0.500 0.617 13.073176 8.227% 13.073176 8.227%
Botteron KN 2002 1038.000000 225.000000 nan 48 1097.000000 74.000000 nan 48167.482835 -0.349 0.206 -0.753 0.054 -1.699 0.089 23.623947 14.867% 23.623947 14.867%
Sheline YI 2003 1057.000000 152.000000 nan 38 1054.000000 154.000000 nan 38153.003268 0.019 0.229 -0.430 0.469 0.085 0.933 18.999057 11.957% 18.999057 11.957%
Hastings RS 2004 1.430000 0.140000 nan 18 1.400000 0.270000 nan 180.215058 0.136 0.334 -0.518 0.791 0.409 0.683 8.976559 5.649% 8.976559 5.649%
Pan CC 2009 1156.400000 130.800000 nan 170 1163.600000 123.300000 nan 83128.397992 -0.056 0.134 -0.318 0.207 -0.417 0.676 55.751240 35.086% 55.751240 35.086%
Meta-analysis (fixed effect) 392 283 -0.115 0.079 -0.270 0.041 -1.448 0.148 100%
Meta-analysis (random effects, DSL) -0.115 0.079 -0.270 0.041 -1.448 0.148 100%
σa: 0.000000 Q: 4.887001 dof: 6.0 P-value: 0.558

Forest plot

-2 -1 0 1 2 Krishnan KR 0.000000 Dupont RM (A) 1.000000 Pillay SS 2.000000 Botteron KN 3.000000 Sheline YI 4.000000 Hastings RS 5.000000 Pan CC 6.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.10 -0.20 -0.30 -0.40 0.10 0.20 0.30 0.40 0.10 0.20 0.30 0.40

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.