Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Lammers C199120205949657610453.875.0MRI1.542015336
Wu JC199320166.861.675.810.9132.955.022.30.00.00.0100.0MRI1.558326077
Parashos IA199872387.181.26.561.14062.538.5MRI1.559870413
Lacerda AL200522395.760.985.990.9541.486.40.00.00.0100.0MRI1.5315804385
Sun J200945300.460.050.490.0740.7851.126.1682.217.8MRI1.51.519486330
Walterfang M2009depressed2616725.99116.97716.67115.4432.1580.820.853.716.7MRI1.5119019454
Walterfang M2009remitted2816684.3299.73716.67115.4436.3675.026.683.716.7MRI1.5119019454

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Lammers C 1991 594.000000 96.000000 nan 20 576.000000 104.000000 nan 20100.079968 0.176 0.317 -0.445 0.797 0.556 0.578 9.957096 10.628% 4.104061 13.172%
Wu JC 1993 6.860000 1.670000 nan 20 5.810000 0.910000 nan 161.387026 0.740 0.348 0.058 1.422 2.128 0.033 8.261412 8.818% 3.783939 12.144%
Parashos IA 1998 7.180000 1.200000 nan 72 6.560000 1.140000 nan 381.179788 0.522 0.204 0.123 0.921 2.562 0.010 24.103027 25.726% 5.413635 17.374%
Lacerda AL 2005 5.760000 0.980000 nan 22 5.990000 0.950000 nan 390.960785 -0.236 0.268 -0.761 0.288 -0.883 0.377 13.969409 14.910% 4.655164 14.940%
Sun J 2009 0.460000 0.050000 nan 45 0.490000 0.070000 nan 300.058766 -0.505 0.239 -0.975 -0.036 -2.110 0.035 17.436281 18.611% 4.985495 16.000%
Walterfang M 2009 725.990000 116.970000 nan 26 716.670000 115.440000 nan 16116.398607 0.079 0.318 -0.544 0.702 0.247 0.805 9.896814 10.563% 4.093783 13.139%
Walterfang M 2009 684.320000 99.730000 nan 28 716.670000 115.440000 nan 16105.609329 -0.301 0.315 -0.919 0.317 -0.954 0.340 10.066062 10.744% 4.122455 13.231%
Meta-analysis (fixed effect) 233 175 0.065 0.103 -0.138 0.267 0.629 0.529 100%
Meta-analysis (random effects, DSL) 0.058 0.179 -0.293 0.409 0.325 0.745 100%
σa: 0.378458 Q: 17.207448 dof: 6.0 P-value: 0.009

Forest plot

-2 -1 0 1 2 Lammers C 0.000000 Wu JC 1.000000 Parashos IA 2.000000 Lacerda AL 3.000000 Sun J 4.000000 Walterfang M 5.000000 Walterfang M 6.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.20 -0.40 -0.60 -0.80 0.20 0.40 0.60 0.80 0.10 0.20 0.30 0.40

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.