Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Wu JC199320167.970.617.580.4432.955.022.3000100MRI1.558326077
Lacerda AL200522397.360.527.340.4341.486.4000100MRI1.5315804385
Walterfang M2009depressed2616100.786.73104.156.6932.1580.820.85417MRI1.5119019454
Walterfang M2009remitted2816100.448.13104.156.6936.3675.026.68417MRI1.5119019454

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Wu JC 1993 7.970000 0.610000 nan 20 7.580000 0.440000 nan 160.541618 0.704 0.347 0.024 1.384 2.031 0.042 8.317330 19.861% 3.353831 23.132%
Lacerda AL 2005 7.360000 0.520000 nan 22 7.340000 0.430000 nan 390.464039 0.043 0.267 -0.480 0.565 0.160 0.873 14.062436 33.580% 4.015306 27.694%
Walterfang M 2009 100.780000 6.730000 nan 26 104.150000 6.690000 nan 166.715028 -0.492 0.323 -1.125 0.140 -1.526 0.127 9.601848 22.928% 3.545066 24.451%
Walterfang M 2009 100.440000 8.130000 nan 28 104.150000 6.690000 nan 167.646907 -0.476 0.318 -1.099 0.147 -1.499 0.134 9.896329 23.631% 3.584446 24.723%
Meta-analysis (fixed effect) 96 87 -0.071 0.155 -0.374 0.232 -0.462 0.644 100%
Meta-analysis (random effects, DSL) -0.064 0.263 -0.578 0.451 -0.242 0.809 100%
σa: 0.421824 Q: 8.509558 dof: 3.0 P-value: 0.037

Forest plot

-2 -1 0 1 2 Wu JC 0.000000 Lacerda AL 1.000000 Walterfang M 2.000000 Walterfang M 3.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.20 -0.40 -0.60 -0.80 0.20 0.40 0.60 0.80 0.10 0.20 0.30 0.40

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.