Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Keshavan MS199619191.630.961.370.68084.253.8MRI18723302
Kumar A199728291.730.950.890.8174.260.719.57MRI1.559169241
Lenze EJ (A)1999242410.810.830.4352.7100.067MRI1.510518173
Greenwald BS2001hyperintensive40211.821.111.860.6574.672.558.326.35MRI1611559382
Greenwald BS2001normotensive41491.341.111.141.1574.770.726.44MRI1611559382
Iosifescu DV2005Low folate1517.50.70.850.310.5340.6113.327.819.9100MRI1.5516298109
Iosifescu DV2005normal folate3517.50.210.530.310.5340.648.627.819.9100MRI1.5516298109
Lin HF200537180.880.740.880.772.262.263.721.9MRI3516248124
Lloyd AJ200451396.54.196.86.217480.457MRI1115172942
Naish JH2006treatment responsive21116.785.655.44.77157.1MRI1.5316894588
Naish JH2006treatment resistant8119.26.365.44.771150.0MRI1.5316894588
Weber K2009386234.113.364.7366.1181.637.7647MRI30.920018381

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Keshavan MS 1996 1.630000 0.960000 nan 19 1.370000 0.680000 nan 190.831865 0.306 0.327 -0.334 0.946 0.937 0.349 9.377549 5.912% 7.409087 6.684%
Kumar A 1997 1.730000 0.950000 nan 28 0.890000 0.810000 nan 290.881510 0.940 0.280 0.391 1.489 3.354 0.001 12.735458 8.029% 9.358682 8.443%
Lenze EJ (A) 1999 1.000000 0.810000 nan 24 0.830000 0.430000 nan 240.648460 0.258 0.290 -0.310 0.826 0.889 0.374 11.892317 7.498% 8.895244 8.025%
Greenwald BS 2001 1.820000 1.110000 nan 40 1.860000 0.650000 nan 210.978601 -0.040 0.270 -0.569 0.488 -0.150 0.881 13.767787 8.680% 9.904419 8.936%
Greenwald BS 2001 1.340000 1.110000 nan 41 1.140000 1.150000 nan 491.131993 0.175 0.212 -0.241 0.591 0.826 0.409 22.233744 14.018% 13.641002 12.307%
Iosifescu DV 2005 0.700000 0.850000 nan 15 0.310000 0.530000 nan 180.695415 0.547 0.359 -0.157 1.251 1.522 0.128 7.749169 4.886% 6.354136 5.733%
Iosifescu DV 2005 0.210000 0.530000 nan 35 0.310000 0.530000 nan 180.530000 -0.186 0.293 -0.761 0.389 -0.634 0.526 11.618453 7.325% 8.741129 7.886%
Lin HF 2005 0.880000 0.740000 nan 37 0.880000 0.700000 nan 180.727409 0.000 0.287 -0.563 0.563 0.000 1.000 12.109091 7.634% 9.015970 8.134%
Lloyd AJ 2004 6.500000 4.190000 nan 51 6.800000 6.210000 nan 395.160207 -0.058 0.213 -0.475 0.359 -0.271 0.786 22.090576 13.927% 13.586977 12.258%
Naish JH 2006 6.780000 5.650000 nan 21 5.400000 4.700000 nan 115.352102 0.251 0.374 -0.481 0.984 0.673 0.501 7.160563 4.515% 5.952893 5.371%
Naish JH 2006 9.200000 6.360000 nan 8 5.400000 4.700000 nan 115.445166 0.667 0.480 -0.275 1.608 1.388 0.165 4.335333 2.733% 3.861086 3.483%
Weber K 2009 3.000000 4.110000 nan 38 3.360000 4.730000 nan 624.505954 -0.079 0.206 -0.483 0.325 -0.385 0.700 23.541854 14.842% 14.122447 12.741%
Meta-analysis (fixed effect) 357 318 0.157 0.079 0.001 0.312 1.975 0.048 100%
Meta-analysis (random effects, DSL) 0.175 0.095 -0.011 0.361 1.839 0.066 100%
σa: 0.168320 Q: 15.041939 dof: 11.0 P-value: 0.181

Forest plot

-2 -1 0 1 2 Keshavan MS 0.000000 Kumar A 1.000000 Lenze EJ (A) 2.000000 Greenwald BS 3.000000 Greenwald BS 4.000000 Iosifescu DV 5.000000 Iosifescu DV 6.000000 Lin HF 7.000000 Lloyd AJ 8.000000 Naish JH 9.000000 Naish JH 10.000000 Weber K 11.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.30 -0.60 -0.90 -1.20 0.30 0.60 0.90 1.20 0.20 0.40 0.60 0.80

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.