Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Pantel J1997191351.529.9353.688.1772.478.964.226.7MRI1.51.259089060
Nolan CL2002222250.46.9550.357.2854.512.18MRI1.51.511825139
Salokangas RK2002psychosis209.557.697.7561.558.593460.0MRI1.55.412271802
Salokangas RK2002no psychosis179.559.189.8161.558.5938.452.9MRI1.55.412271802
Lavretsky H2005antidepressant exposure1120.50.0680.0040.0660.00667.463.636.417.7000100MRI1.51.416086609
Lavretsky H2005no antidepressant exposure3020.50.0650.0050.0660.00671.783.352.517.7000100MRI1.51.416086609
Frodl T2006343494.35.396.86.545.544.138.824.891129MRI1.516951734

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Pantel J 1997 51.520000 9.930000 nan 19 53.680000 8.170000 nan 139.266202 -0.227 0.361 -0.935 0.481 -0.629 0.529 7.664321 11.480% 7.664321 11.480%
Nolan CL 2002 50.400000 6.950000 nan 22 50.350000 7.280000 nan 227.116913 0.007 0.302 -0.584 0.598 0.023 0.982 10.999928 16.477% 10.999928 16.477%
Salokangas RK 2002 57.690000 7.750000 nan 20 61.550000 8.590000 nan 108.019037 -0.468 0.399 -1.251 0.315 -1.172 0.241 6.267643 9.388% 6.267643 9.388%
Salokangas RK 2002 59.180000 9.810000 nan 17 61.550000 8.590000 nan 109.404681 -0.244 0.407 -1.041 0.553 -0.600 0.548 6.045641 9.056% 6.045641 9.056%
Lavretsky H 2005 0.068000 0.004000 nan 11 0.066000 0.006000 nan 200.005406 0.361 0.377 -0.378 1.099 0.957 0.339 7.039906 10.545% 7.039906 10.545%
Lavretsky H 2005 0.065000 0.005000 nan 30 0.066000 0.006000 nan 200.005424 -0.181 0.287 -0.744 0.381 -0.632 0.527 12.125982 18.163% 12.125982 18.163%
Frodl T 2006 94.300000 5.300000 nan 34 96.800000 6.500000 nan 345.930430 -0.417 0.245 -0.898 0.064 -1.699 0.089 16.617061 24.891% 16.617061 24.891%
Meta-analysis (fixed effect) 153 129 -0.190 0.122 -0.430 0.050 -1.550 0.121 100%
Meta-analysis (random effects, DSL) -0.190 0.122 -0.430 0.050 -1.550 0.121 100%
σa: 0.000000 Q: 3.928276 dof: 6.0 P-value: 0.686

Forest plot

-2 -1 0 1 2 Pantel J 0.000000 Nolan CL 1.000000 Salokangas RK 2.000000 Salokangas RK 3.000000 Lavretsky H 4.000000 Lavretsky H 5.000000 Frodl T 6.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.20 -0.40 -0.60 -0.80 0.20 0.40 0.60 0.80 0.20 0.40 0.60 0.80

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.