Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Pantel J1997191351.169.4752.396.3272.478.964.226.7MRI1.51.259089060
Nolan CL2002222252.366.3851.668.0654.512.18MRI1.51.511825139
Salokangas RK2002psychosis209.557.916.9661.499.253460.0MRI1.55.412271802
Salokangas RK2002no psychosis179.560.7510.3461.499.2538.452.9MRI1.55.412271802
Lavretsky H2005antidepressant exposure1120.50.0670.0040.0650.00667.463.636.417.7000100MRI1.51.416086609
Lavretsky H2005no antidepressant exposure3020.50.0650.0050.0650.00671.783.352.517.7000100MRI1.51.416086609
Frodl T2006343499.15.6101.36.145.544.138.824.891129MRI1.516951734

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Pantel J 1997 51.160000 9.470000 nan 19 52.390000 6.320000 nan 138.353772 -0.144 0.360 -0.850 0.563 -0.398 0.690 7.696942 11.494% 7.696942 11.494%
Nolan CL 2002 52.360000 6.380000 nan 22 51.660000 8.060000 nan 227.268700 0.095 0.302 -0.497 0.686 0.313 0.754 10.986509 16.406% 10.986509 16.406%
Salokangas RK 2002 57.910000 6.960000 nan 20 61.490000 9.250000 nan 107.740500 -0.450 0.399 -1.232 0.332 -1.127 0.260 6.280601 9.379% 6.280601 9.379%
Salokangas RK 2002 60.750000 10.340000 nan 17 61.490000 9.250000 nan 109.975339 -0.072 0.405 -0.866 0.722 -0.177 0.859 6.090089 9.094% 6.090089 9.094%
Lavretsky H 2005 0.067000 0.004000 nan 11 0.065000 0.006000 nan 200.005406 0.361 0.377 -0.378 1.099 0.957 0.339 7.039906 10.513% 7.039906 10.513%
Lavretsky H 2005 0.065000 0.005000 nan 30 0.065000 0.006000 nan 200.005424 0.000 0.287 -0.562 0.562 0.000 1.000 12.178218 18.185% 12.178218 18.185%
Frodl T 2006 99.100000 5.600000 nan 34 101.300000 6.100000 nan 345.855339 -0.371 0.245 -0.851 0.108 -1.518 0.129 16.694382 24.929% 16.694382 24.929%
Meta-analysis (fixed effect) 153 129 -0.104 0.122 -0.344 0.135 -0.854 0.393 100%
Meta-analysis (random effects, DSL) -0.104 0.122 -0.344 0.135 -0.854 0.393 100%
σa: 0.000000 Q: 4.047115 dof: 6.0 P-value: 0.670

Forest plot

-2 -1 0 1 2 Pantel J 0.000000 Nolan CL 1.000000 Salokangas RK 2.000000 Salokangas RK 3.000000 Lavretsky H 4.000000 Lavretsky H 5.000000 Frodl T 6.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.20 -0.40 -0.60 -0.80 0.20 0.40 0.60 0.80 0.20 0.40 0.60 0.80

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.