Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Pantel J19971913102.6818.40503083106.0713.7588640572.478.964.226.7MRI1.51.259089060
Nolan CL20022222102.7612.6472329102.0114.5548919654.512.18MRI1.51.511825139
Salokangas RK2002209.5115.614.26123.0417.673460.0MRI1.55.412271802
Salokangas RK2002179.5119.9320.03123.0417.6738.452.9MRI1.55.412271802
Steingard RJ2002183797.515.790.223.815.488.917.30.0100.0MRI1.51.512242057
Lavretsky H20051120.50.1350.0130.1310.007267.463.636.417.70.00.00.0100.0MRI1.51.416086609
Lavretsky H20053020.50.130.010.1310.007271.783.352.517.70.00.00.0100.0MRI1.51.416086609
Frodl T20063434193.410.34108312198.111.954078845.544.138.824.891.211.88.8MRI1.516951734

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Pantel J 1997 102.680000 18.405031 nan 19 106.070000 13.758864 nan 1316.702384 -0.198 0.361 -0.905 0.510 -0.548 0.584 7.677416 9.749% 7.677416 9.749%
Nolan CL 2002 102.760000 12.647233 nan 22 102.010000 14.554892 nan 2213.634467 0.054 0.302 -0.537 0.645 0.179 0.858 10.995595 13.963% 10.995595 13.963%
Salokangas RK 2002 115.600000 14.260000 nan 20 123.040000 17.670000 nan 1015.394863 -0.470 0.399 -1.253 0.313 -1.176 0.239 6.266295 7.957% 6.266295 7.957%
Salokangas RK 2002 119.930000 20.030000 nan 17 123.040000 17.670000 nan 1019.244040 -0.157 0.406 -0.952 0.639 -0.386 0.700 6.074217 7.713% 6.074217 7.713%
Steingard RJ 2002 97.500000 15.700000 nan 18 90.200000 23.800000 nan 3721.536354 0.334 0.289 -0.233 0.901 1.155 0.248 11.950870 15.176% 11.950870 15.176%
Lavretsky H 2005 0.135000 0.013000 nan 11 0.131000 0.007200 nan 200.009568 0.407 0.378 -0.333 1.148 1.078 0.281 7.007730 8.899% 7.007730 8.899%
Lavretsky H 2005 0.130000 0.010000 nan 30 0.131000 0.007200 nan 200.008980 -0.110 0.287 -0.672 0.452 -0.382 0.702 12.159106 15.440% 12.159106 15.440%
Frodl T 2006 193.400000 10.341083 nan 34 198.100000 11.954079 nan 3411.176717 -0.416 0.245 -0.897 0.065 -1.695 0.090 16.618902 21.103% 16.618902 21.103%
Meta-analysis (fixed effect) 171 166 -0.079 0.113 -0.300 0.142 -0.700 0.484 100%
Meta-analysis (random effects, DSL) -0.079 0.113 -0.300 0.142 -0.700 0.484 100%
σa: 0.000000 Q: 6.890382 dof: 7.0 P-value: 0.440

Forest plot

-2 -1 0 1 2 Pantel J 0.000000 Nolan CL 1.000000 Salokangas RK 2.000000 Salokangas RK 3.000000 Steingard RJ 4.000000 Lavretsky H 5.000000 Lavretsky H 6.000000 Frodl T 7.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.20 -0.40 -0.60 -0.80 0.20 0.40 0.60 0.80 0.20 0.40 0.60 0.80

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.