Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Bremner JD2000161614085641597154267241414337.5100000MRI1.5310618023
McIntosh AM200192964773406370119971543.5655.6MRI11.8811200955
Nolan CL2002222270.0211.1568.649.7854.512.18MRI1.51.511825139
Almeida OP2003early onset2418.548131989947749703172.895.839.2MRI1112785469
Almeida OP2003late onset2718.546461628447749703175.566.772.4MRI1112785469
Lavretsky H2005antidepressant exposure1120.50.1180.0060.1170.00867.463.636.417.7000100MRI1.51.416086609
Lavretsky H2005no antidepressant exposure3020.50.1160.010.1170.00871.783.352.517.7000100MRI1.51.416086609

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Bremner JD 2000 140856.000000 41597.000000 nan 16 154267.000000 24141.000000 nan 1634008.074703 -0.384 0.357 -1.085 0.316 -1.076 0.282 7.834960 11.851% 7.834960 11.851%
McIntosh AM 2001 64773.000000 4063.000000 nan 9 70119.000000 9715.000000 nan 298779.297068 -0.596 0.388 -1.357 0.165 -1.535 0.125 6.630808 10.030% 6.630808 10.030%
Nolan CL 2002 70.020000 11.150000 nan 22 68.640000 9.780000 nan 2210.487395 0.129 0.302 -0.462 0.721 0.428 0.669 10.974839 16.600% 10.974839 16.600%
Almeida OP 2003 48131.000000 9899.000000 nan 24 47749.000000 7031.000000 nan 188775.508062 0.043 0.309 -0.564 0.649 0.138 0.890 10.444477 15.798% 10.444477 15.798%
Almeida OP 2003 46461.000000 6284.000000 nan 27 47749.000000 7031.000000 nan 186594.698103 -0.192 0.303 -0.785 0.401 -0.634 0.526 10.924875 16.525% 10.924875 16.525%
Lavretsky H 2005 0.118000 0.006000 nan 11 0.117000 0.008000 nan 200.007383 0.132 0.374 -0.601 0.865 0.353 0.724 7.142573 10.804% 7.142573 10.804%
Lavretsky H 2005 0.116000 0.010000 nan 30 0.117000 0.008000 nan 200.009248 -0.106 0.287 -0.669 0.456 -0.371 0.710 12.160197 18.393% 12.160197 18.393%
Meta-analysis (fixed effect) 139 145 -0.114 0.123 -0.355 0.127 -0.928 0.353 100%
Meta-analysis (random effects, DSL) -0.114 0.123 -0.355 0.127 -0.928 0.353 100%
σa: 0.000000 Q: 3.519330 dof: 6.0 P-value: 0.741

Forest plot

-2 -1 0 1 2 Bremner JD 0.000000 McIntosh AM 1.000000 Nolan CL 2.000000 Almeida OP 3.000000 Almeida OP 4.000000 Lavretsky H 5.000000 Lavretsky H 6.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.20 -0.40 -0.60 -0.80 0.20 0.40 0.60 0.80 0.10 0.20 0.30 0.40

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.