Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Bremner JD2000161614310145265164471271504337.5100000MRI1.5310618023
McIntosh AM2001929714584891741591032243.5655.6MRI11.8811200955
Nolan CL2002222278.311.5276.6811.7954.512.18MRI1.51.511825139
Almeida OP2003early onset2418.550904901349590683872.895.839.2MRI1112785469
Almeida OP2003late onset2718.546829747649590683875.566.772.4MRI1112785469
Lavretsky H2005antidepressant exposure1120.50.1180.0080.1180.00667.463.636.417.7000100MRI1.51.416086609
Lavretsky H2005no antidepressant exposure3020.50.1170.0080.1180.00671.783.352.517.7000100MRI1.51.416086609

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Bremner JD 2000 143101.000000 45265.000000 nan 16 164471.000000 27150.000000 nan 1637323.201397 -0.558 0.361 -1.266 0.150 -1.545 0.122 7.659853 11.616% 7.659853 11.616%
McIntosh AM 2001 71458.000000 4891.000000 nan 9 74159.000000 10322.000000 nan 299390.595473 -0.282 0.383 -1.032 0.469 -0.735 0.462 6.813942 10.333% 6.813942 10.333%
Nolan CL 2002 78.300000 11.520000 nan 22 76.680000 11.790000 nan 2211.655782 0.136 0.302 -0.455 0.728 0.452 0.651 10.971937 16.639% 10.971937 16.639%
Almeida OP 2003 50904.000000 9013.000000 nan 24 49590.000000 6838.000000 nan 188144.763003 0.158 0.310 -0.449 0.766 0.511 0.609 10.411704 15.789% 10.411704 15.789%
Almeida OP 2003 46829.000000 7476.000000 nan 27 49590.000000 6838.000000 nan 187226.108865 -0.375 0.305 -0.972 0.222 -1.233 0.218 10.777362 16.344% 10.777362 16.344%
Lavretsky H 2005 0.118000 0.008000 nan 11 0.118000 0.006000 nan 200.006745 0.000 0.374 -0.733 0.733 0.000 1.000 7.158730 10.856% 7.158730 10.856%
Lavretsky H 2005 0.117000 0.008000 nan 30 0.118000 0.006000 nan 200.007262 -0.136 0.287 -0.698 0.427 -0.472 0.637 12.149022 18.424% 12.149022 18.424%
Meta-analysis (fixed effect) 139 145 -0.133 0.123 -0.374 0.109 -1.076 0.282 100%
Meta-analysis (random effects, DSL) -0.133 0.123 -0.374 0.109 -1.076 0.282 100%
σa: 0.000000 Q: 3.975617 dof: 6.0 P-value: 0.680

Forest plot

-2 -1 0 1 2 Bremner JD 0.000000 McIntosh AM 1.000000 Nolan CL 2.000000 Almeida OP 3.000000 Almeida OP 4.000000 Lavretsky H 5.000000 Lavretsky H 6.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.20 -0.40 -0.60 -0.80 0.20 0.40 0.60 0.80 0.10 0.20 0.30 0.40

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.