Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Parashos IA19987238235.632.08246.1741.955.462.538.5MRI1.559870413
Bremner JD2000161628395782412.6917531873848668.217774337.5100.00.00.00.0MRI1.5310618023
Kumar A (A)20005130168.0330.8197.5131.0974.370.619.8MRI1.5510693154
McIntosh AM20019291362318498.54474614427819009.7363743.5655.6MRI11.8811200955
Nolan CL20022222148.3221.50696864145.3220.4729680313.754.512.18MRI1.51.511825139
Almeida OP2003early onset2418.59903618349973391358172.895.839.2MRI1112785469
Almeida OP2003late onset2718.59329113216973391358175.566.772.4MRI1112785469
Lavretsky H2005antidepressant exposure1120.50.2360.0190.2360.01667.463.636.417.70.00.00.0100.0MRI1.51.416086609
Lavretsky H2005no antidepressant exposure3020.50.2330.0170.2360.01671.783.352.517.70.00.00.0100.0MRI1.51.416086609

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Parashos IA 1998 235.600000 32.080000 nan 72 246.170000 41.900000 nan 3835.749326 -0.294 0.202 -0.689 0.101 -1.457 0.145 24.623816 22.876% 11.702182 17.389%
Bremner JD 2000 283957.000000 82412.691750 nan 16 318738.000000 48668.217770 nan 1667677.349174 -0.501 0.360 -1.206 0.204 -1.392 0.164 7.723678 7.175% 5.736739 8.525%
Kumar A (A) 2000 168.030000 30.800000 nan 51 197.510000 31.090000 nan 3030.906772 -0.945 0.242 -1.420 -0.470 -3.898 0.000 17.026352 15.818% 9.654789 14.347%
McIntosh AM 2001 136231.000000 8498.544746 nan 9 144278.000000 19009.736370 nan 2917237.043648 -0.457 0.386 -1.213 0.299 -1.185 0.236 6.726739 6.249% 5.167865 7.679%
Nolan CL 2002 148.320000 21.506969 nan 22 145.320000 20.472968 nan 2220.996334 0.140 0.302 -0.451 0.732 0.465 0.642 10.970346 10.192% 7.353056 10.926%
Almeida OP 2003 99036.000000 18349.000000 nan 24 97339.000000 13581.000000 nan 1816459.104382 0.101 0.310 -0.506 0.708 0.327 0.744 10.432590 9.692% 7.107496 10.562%
Almeida OP 2003 93291.000000 13216.000000 nan 27 97339.000000 13581.000000 nan 1813364.037670 -0.298 0.304 -0.893 0.297 -0.980 0.327 10.851052 10.081% 7.299269 10.846%
Lavretsky H 2005 0.236000 0.019000 nan 11 0.236000 0.016000 nan 200.017076 0.000 0.374 -0.733 0.733 0.000 1.000 7.158730 6.651% 5.419096 8.053%
Lavretsky H 2005 0.233000 0.017000 nan 30 0.236000 0.016000 nan 200.016605 -0.178 0.287 -0.741 0.385 -0.619 0.536 12.128044 11.267% 7.855670 11.673%
Meta-analysis (fixed effect) 262 213 -0.307 0.096 -0.496 -0.118 -3.186 0.001 100%
Meta-analysis (random effects, DSL) -0.291 0.122 -0.530 -0.053 -2.391 0.017 100%
σa: 0.211762 Q: 12.182740 dof: 8.0 P-value: 0.143

Forest plot

-2 -1 0 1 2 Parashos IA 0.000000 Bremner JD 1.000000 Kumar A (A) 2.000000 McIntosh AM 3.000000 Nolan CL 4.000000 Almeida OP 5.000000 Almeida OP 6.000000 Lavretsky H 7.000000 Lavretsky H 8.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.30 -0.60 -0.90 -1.20 0.30 0.60 0.90 1.20 0.10 0.20 0.30 0.40

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.