Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Nolan CL2002222219.614.9718.293.0154.512.18MRI1.51.511825139
Salokangas RK2002psychosis209.534.126.8736.145.13460.0MRI1.55.412271802
Salokangas RK2002no psychosis179.538.967.3436.145.138.452.9MRI1.55.412271802
Lavretsky H2004females32200.05080.00690.05140.004970.5100.048.5000100MRI1.51.415545334
Lavretsky H2004males9210.04940.005470.05150.005670.50.048.5000100MRI1.51.415545334
Frodl T2006343468.8568.86.145.544.138.824.891129MRI1.516951734

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Nolan CL 2002 19.610000 4.970000 nan 22 18.290000 3.010000 nan 224.108589 0.316 0.304 -0.279 0.910 1.039 0.299 10.851691 18.497% 10.851691 18.497%
Salokangas RK 2002 34.120000 6.870000 nan 20 36.140000 5.100000 nan 106.375596 -0.308 0.396 -1.085 0.469 -0.777 0.437 6.364553 10.849% 6.364553 10.849%
Salokangas RK 2002 38.960000 7.340000 nan 17 36.140000 5.100000 nan 106.648905 0.411 0.410 -0.392 1.214 1.003 0.316 5.958384 10.156% 5.958384 10.156%
Lavretsky H 2004 0.050800 0.006900 nan 32 0.051400 0.004900 nan 200.006216 -0.095 0.285 -0.654 0.464 -0.333 0.739 12.293466 20.955% 12.293466 20.955%
Lavretsky H 2004 0.049400 0.005470 nan 9 0.051500 0.005600 nan 210.005563 -0.367 0.402 -1.155 0.420 -0.914 0.360 6.198924 10.566% 6.198924 10.566%
Frodl T 2006 68.800000 5.000000 nan 34 68.800000 6.100000 nan 345.577186 0.000 0.243 -0.475 0.475 0.000 1.000 17.000000 28.977% 17.000000 28.977%
Meta-analysis (fixed effect) 134 116 0.008 0.131 -0.248 0.264 0.061 0.951 100%
Meta-analysis (random effects, DSL) 0.008 0.131 -0.248 0.264 0.061 0.951 100%
σa: 0.000000 Q: 3.634594 dof: 5.0 P-value: 0.603

Forest plot

-2 -1 0 1 2 Nolan CL 0.000000 Salokangas RK 1.000000 Salokangas RK 2.000000 Lavretsky H 3.000000 Lavretsky H 4.000000 Frodl T 5.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.20 -0.40 -0.60 -0.80 0.20 0.40 0.60 0.80 0.20 0.40 0.60 0.80

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.