Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Nolan CL2002222245.5512.0120281443.317.11115461854.512.18MRI1.51.511825139
Salokangas RK2002psychosis209.569.3412.4472.8210.393460.0MRI1.55.412271802
Salokangas RK2002no psychosis179.579.0913.9672.8210.3938.452.9MRI1.55.412271802
Steingard RJ2002183759.32178.922.215.488.917.30100MRI1.51.512242057
Lavretsky H2004females32200.1030.0110.1030.01170.5100.048.5000100MRI1.51.415545334
Lavretsky H2004males9210.1020.00990.1030.01170.50.048.5000100MRI1.51.415545334
Frodl T20063434140.49.676776323140.611.5739362445.544.138.824.891129MRI1.516951734

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Nolan CL 2002 45.550000 12.012028 nan 22 43.310000 7.111155 nan 229.870596 0.223 0.303 -0.370 0.816 0.737 0.461 10.925500 15.631% 6.012992 15.552%
Salokangas RK 2002 69.340000 12.440000 nan 20 72.820000 10.390000 nan 1011.844310 -0.286 0.396 -1.062 0.491 -0.721 0.471 6.375105 9.121% 4.317086 11.166%
Salokangas RK 2002 79.090000 13.960000 nan 17 72.820000 10.390000 nan 1012.834422 0.473 0.411 -0.332 1.279 1.151 0.250 5.915268 8.463% 4.101191 10.607%
Steingard RJ 2002 59.300000 21.000000 nan 18 78.900000 22.200000 nan 3721.822284 -0.885 0.300 -1.474 -0.297 -2.947 0.003 11.079219 15.851% 6.059261 15.672%
Lavretsky H 2004 0.103000 0.011000 nan 32 0.103000 0.011000 nan 200.011000 0.000 0.285 -0.559 0.559 0.000 1.000 12.307692 17.609% 6.409124 16.576%
Lavretsky H 2004 0.102000 0.009900 nan 9 0.103000 0.011000 nan 210.010697 -0.091 0.399 -0.872 0.690 -0.228 0.820 6.293706 9.004% 4.279605 11.069%
Frodl T 2006 140.400000 9.676776 nan 34 140.600000 11.573936 nan 3410.667615 -0.019 0.243 -0.494 0.457 -0.076 0.939 16.999225 24.321% 7.484819 19.359%
Meta-analysis (fixed effect) 152 153 -0.104 0.120 -0.339 0.130 -0.871 0.384 100%
Meta-analysis (random effects, DSL) -0.099 0.161 -0.415 0.216 -0.618 0.536 100%
σa: 0.273455 Q: 10.373096 dof: 6.0 P-value: 0.110

Forest plot

-2 -1 0 1 2 Nolan CL 0.000000 Salokangas RK 1.000000 Salokangas RK 2.000000 Steingard RJ 3.000000 Lavretsky H 4.000000 Lavretsky H 5.000000 Frodl T 6.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.30 -0.60 -0.90 -1.20 0.30 0.60 0.90 1.20 0.20 0.40 0.60 0.80

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.