Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Lacerda AL200325482.990.38928138930.45554363141.216.029.4410.91000100MRI1.5514623065
Andreescu C200871320.40.070.440.0972.269.052.318.3171MRI1.51.518075490
Pizzagalli DA200926313317507.69538113499503.8231833057.729.3915.98000100MRI1.51.3319411368

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Lacerda AL 2003 2.990000 0.389281 nan 25 3.000000 0.455544 nan 480.434278 -0.023 0.247 -0.506 0.461 -0.092 0.926 16.437341 31.755% 14.319318 32.079%
Andreescu C 2008 0.400000 0.070000 nan 71 0.440000 0.090000 nan 320.076695 -0.518 0.216 -0.941 -0.094 -2.396 0.017 21.419198 41.379% 17.957923 40.231%
Pizzagalli DA 2009 3317.000000 507.695381 nan 26 3499.000000 503.823183 nan 31505.586950 -0.355 0.268 -0.881 0.171 -1.324 0.185 13.906758 26.866% 12.360004 27.690%
Meta-analysis (fixed effect) 122 111 -0.317 0.139 -0.589 -0.044 -2.279 0.023 100%
Meta-analysis (random effects, DSL) -0.314 0.150 -0.607 -0.021 -2.097 0.036 100%
σa: 0.094861 Q: 2.305453 dof: 2.0 P-value: 0.316

Forest plot

-2 -1 0 1 2 Lacerda AL 0.000000 Andreescu C 1.000000 Pizzagalli DA 2.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.20 -0.40 -0.60 -0.80 0.20 0.40 0.60 0.80 0.08 0.16 0.24 0.32

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.