Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Dupont RM (A)1995302684691.769631.9585494.8712355.4638.670.012.5403057MRI1.557654126
Pillay SS19973820628.577.5626.56838.555.3MRI1.539209723
Frodl T (A)20023030645.649.6648.273.6056.74024.887MRI1.51.511983184
Steingard RJ200219387867477410215.484.217.30100MRI1.51.512242057
Ballmaier M (C)20042419558.571104.869581.831103.55765.8575.03517.33000100MRI1.51.414960291
Maller JJ2007males22130.5970.0630.5750.11260.0MRI1.50.9417604352
Maller JJ2007females23170.5220.06560.5640.0798100.0MRI1.50.9417604352
Penttilä J20093570479.642.59589182489.442.6907952647.268.630.227.437119MRI1.51.319270763
van Eijndhoven P2009depressed2010699567095834.165.034.121.080MRI1.5119028381
van Eijndhoven P2009remitted2010706637095835.870.033.43.40MRI1.5119028381

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Dupont RM (A) 1995 84691.760000 9631.950000 nan 30 85494.870000 12355.460000 nan 2610977.159923 -0.072 0.268 -0.597 0.453 -0.269 0.788 13.918881 11.681% 13.918881 11.681%
Pillay SS 1997 628.500000 77.500000 nan 38 626.500000 68.000000 nan 2074.412851 0.027 0.276 -0.515 0.568 0.096 0.924 13.102332 10.996% 13.102332 10.996%
Frodl T (A) 2002 645.600000 49.600000 nan 30 648.200000 73.600000 nan 3062.757948 -0.041 0.258 -0.547 0.465 -0.158 0.874 14.996645 12.585% 14.996645 12.585%
Steingard RJ 2002 786.000000 74.000000 nan 19 774.000000 102.000000 nan 3893.761399 0.126 0.281 -0.425 0.677 0.449 0.654 12.642621 10.610% 12.642621 10.610%
Ballmaier M (C) 2004 558.571000 104.869000 nan 24 581.831000 103.557000 nan 19104.295032 -0.219 0.308 -0.823 0.385 -0.711 0.477 10.536107 8.842% 10.536107 8.842%
Maller JJ 2007 0.597000 0.063000 nan 22 0.575000 0.112600 nan 130.084476 0.254 0.351 -0.434 0.943 0.724 0.469 8.102415 6.800% 8.102415 6.800%
Maller JJ 2007 0.522000 0.065600 nan 23 0.564000 0.079800 nan 170.071921 -0.572 0.327 -1.213 0.068 -1.751 0.080 9.359414 7.855% 9.359414 7.855%
Penttilä J 2009 479.600000 42.595892 nan 35 489.400000 42.690795 nan 7042.659491 -0.228 0.208 -0.635 0.179 -1.098 0.272 23.194081 19.465% 23.194081 19.465%
van Eijndhoven P 2009 699.000000 56.000000 nan 20 709.000000 58.000000 nan 1056.650558 -0.172 0.388 -0.932 0.589 -0.443 0.658 6.641607 5.574% 6.641607 5.574%
van Eijndhoven P 2009 706.000000 63.000000 nan 20 709.000000 58.000000 nan 1061.437250 -0.048 0.387 -0.807 0.712 -0.123 0.902 6.664742 5.593% 6.664742 5.593%
Meta-analysis (fixed effect) 261 253 -0.101 0.092 -0.280 0.079 -1.101 0.271 100%
Meta-analysis (random effects, DSL) -0.101 0.092 -0.280 0.079 -1.101 0.271 100%
σa: 0.000000 Q: 4.608143 dof: 9.0 P-value: 0.867

Forest plot

-2 -1 0 1 2 Dupont RM (A) 0.000000 Pillay SS 1.000000 Frodl T (A) 2.000000 Steingard RJ 3.000000 Ballmaier M (C) 4.000000 Maller JJ 5.000000 Maller JJ 6.000000 Penttilä J 7.000000 van Eijndhoven P 8.000000 van Eijndhoven P 9.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.20 -0.40 -0.60 -0.80 0.20 0.40 0.60 0.80 0.10 0.20 0.30 0.40

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.