Brede meta-analysis


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Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Ashtari M199940461745380185334874.370.061.526.1MRI13.110405084
Bremner JD2000161694020811662484337.5100000MRI1.5310618023
Vakili K200038202.640.552.460.3838.555.3MRI1.5310862809
Rusch BD200125152.170.262.130.2733.256.019.4100MRI1.51.211750892
MacMillan S200323233.150.393.240.4456.511.84000100MRI1.51.512804127
MacQueen GM200320202738301.12761368.428.465.026.319.10MRI1.51.212552118
MacQueen GM2003first episode17172381273.5270324935.964.724.917.50MRI1.51.212552118
Posener JA2003multiple episode27422546392.72475359.43355.627.3MRI1.5112505805
Sheline YI200338382171316242131850.8100.06.7MRI1.512900317
Caetano SC200431313.320.483.370.4239.277.427.911.8000100MRI1.51.515598548
Janssen J200428413.10.373.20.5264.04100.033.0461251421MRI1.51.215576058
Lange C200417172.790.412.990.4634100.029221000MRI1.51.315554576
Lloyd AJ200451392.70.42.80.47480.457MRI1115172942
MacMaster FP (A)200417172.530.3713.050.45416.6752.914.0660082MRI1.51.514969587
Vythilingam M20043833330538033343904160.5039MRI1.51.515231442
Xia J200422133109.8683.5335245.5339.545.521.45MRI1.51.215641704
Rosso IM200520246.570.766.260.73515.3585.012.816.55000100MRI1.51.515607296
Taylor WD (B)2005135832.950.432.960.457066.746.9MRI1.5315867107
Saylam C200624242638.7249.22786.7249.233.475.024.4000100MRI1.5216395541
Weniger G200621232.70.430.534100.028231000MRI1.51.316740316
Velakoulis D200612872849442287035822.641.721.5MRI1.51.516461856
Caetano SC200719241.890.161.990.181331.610.34753MRI1.5117949901
Colla M200724141.680.271.860.1554.562.525.3000MRI1.51.0517023001
Maller JJ200722133010.56291.43270.01429.5737.290.0MRI1.50.9417604352
Maller JJ200723172781.15376.582989.96252.1437.47100.0MRI1.50.9417604352
Ballmaier M (A)200846341116.12221272.75257.6571.173.951.4317.73000100MRI1.51.417986679
Keller J2008psychosis23113.860.583.780.4936.547.827.630.565177017MRI31.518450931
Keller J2008no psychosis19113.850.33.780.4936.663.22723.75811042MRI31.518450931
MacMaster FP (B)200816172.760.273.060.4914.0856.311.77000100MRI1.51.517640621
Tae WS200821202589.3377.242811.1226.5141.7100.033.2100000MRI1.51.318414838
Bergouignan L200921213.950.754.421.0433.1681.023.81000MRI1.51.519071222
van Eijndhoven P200920103620385371636434.165.034.121.080MRI1.5119028381
van Eijndhoven P200920103600360371636435.870.033.43.40MRI1.5119028381
Meisenzahl EM2009921383.670.413.830.4144.651.123.5147MRI1.51.519488671
Jessen F200979842.060.272.360.2948.265.8MRI1119668114
Kaymak SU200920152.850.333.520.3332100.023.1000100MRI3119756819
Kronmüller KT2009males, first episode135.52.810.363.190.2538.080.038.88231000MRI1.51.519800203
Kronmüller KT2009females, first episode139.52.710.262.720.341.46100.038.8825.621000MRI1.51.519800203
Kronmüller KT2009males, recurrent115.53.10.393.190.2548.270.038.2618.721000MRI1.51.519800203
Kronmüller KT2009females, recurrent209.52.750.412.720.345.85100.038.2622.91000MRI1.51.519800203
Milne A200928142159.5260.82438.8307.947.2953.68.2339757MRI31.219324095
Weber K200938621.740.231.760.2666.1181.637.7647MRI30.920018381

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Ashtari M 1999 1745.000000 380.000000 nan 40 1853.000000 348.000000 nan 46363.207929 -0.295 0.217 -0.721 0.131 -1.355 0.175 21.155845 3.829% 4.664185 2.966%
Bremner JD 2000 940.000000 208.000000 nan 16 1166.000000 248.000000 nan 16228.875512 -0.963 0.376 -1.700 -0.225 -2.559 0.011 7.066685 1.279% 3.240015 2.061%
Vakili K 2000 2.640000 0.550000 nan 38 2.460000 0.380000 nan 200.498858 0.356 0.278 -0.190 0.902 1.279 0.201 12.905262 2.336% 4.087986 2.600%
Rusch BD 2001 2.170000 0.260000 nan 25 2.130000 0.270000 nan 150.263728 0.149 0.327 -0.492 0.790 0.455 0.649 9.348146 1.692% 3.648243 2.320%
MacMillan S 2003 3.150000 0.390000 nan 23 3.240000 0.440000 nan 230.415752 -0.213 0.296 -0.793 0.367 -0.719 0.472 11.429268 2.069% 3.927327 2.498%
MacQueen GM 2003 2738.000000 301.100000 nan 20 2761.000000 368.400000 nan 20336.437045 -0.067 0.316 -0.687 0.553 -0.212 0.832 9.993779 1.809% 3.742603 2.380%
MacQueen GM 2003 2381.000000 273.500000 nan 17 2703.000000 249.000000 nan 17261.537043 -1.202 0.376 -1.940 -0.464 -3.194 0.001 7.058007 1.277% 3.238190 2.059%
Posener JA 2003 2546.000000 392.700000 nan 27 2475.000000 359.400000 nan 42372.675849 0.188 0.247 -0.296 0.673 0.762 0.446 16.361453 2.961% 4.381147 2.786%
Sheline YI 2003 2171.000000 316.000000 nan 38 2421.000000 318.000000 nan 38317.001577 -0.781 0.238 -1.248 -0.313 -3.274 0.001 17.587127 3.183% 4.464461 2.839%
Caetano SC 2004 3.320000 0.480000 nan 31 3.370000 0.420000 nan 310.450999 -0.109 0.254 -0.608 0.389 -0.431 0.667 15.475244 2.801% 4.314980 2.744%
Janssen J 2004 3.100000 0.370000 nan 28 3.200000 0.520000 nan 410.465405 -0.212 0.246 -0.694 0.269 -0.864 0.388 16.542211 2.994% 4.394004 2.794%
Lange C 2004 2.790000 0.410000 nan 17 2.990000 0.460000 nan 170.435718 -0.448 0.348 -1.130 0.234 -1.288 0.198 8.265284 1.496% 3.470783 2.207%
Lloyd AJ 2004 2.700000 0.400000 nan 51 2.800000 0.400000 nan 390.400000 -0.248 0.214 -0.666 0.171 -1.161 0.246 21.927032 3.969% 4.700634 2.989%
MacMaster FP (A) 2004 2.530000 0.371000 nan 17 3.050000 0.454000 nan 170.414582 -1.225 0.378 -1.965 -0.485 -3.243 0.001 7.012961 1.269% 3.228675 2.053%
Vythilingam M 2004 3305.000000 380.000000 nan 38 3334.000000 390.000000 nan 33384.670007 -0.075 0.238 -0.541 0.392 -0.313 0.754 17.649049 3.194% 4.468440 2.842%
Xia J 2004 3109.860000 83.500000 nan 22 3352.000000 45.530000 nan 1372.046496 -3.284 0.544 -4.350 -2.218 -6.036 0.000 3.378618 0.612% 2.159312 1.373%
Rosso IM 2005 6.570000 0.760000 nan 20 6.260000 0.735000 nan 240.746413 0.408 0.306 -0.192 1.008 1.332 0.183 10.667473 1.931% 3.833263 2.438%
Taylor WD (B) 2005 2.950000 0.430000 nan 135 2.960000 0.450000 nan 830.437700 -0.023 0.139 -0.296 0.251 -0.163 0.870 51.395884 9.302% 5.359394 3.408%
Saylam C 2006 2638.700000 249.200000 nan 24 2786.700000 249.200000 nan 24249.200000 -0.584 0.295 -1.163 -0.005 -1.978 0.048 11.467118 2.075% 3.931786 2.501%
Weniger G 2006 2.700000 0.400000 nan 21 3.000000 0.500000 nan 230.455129 -0.647 0.310 -1.256 -0.039 -2.086 0.037 10.381292 1.879% 3.795663 2.414%
Velakoulis D 2006 2849.000000 442.000000 nan 12 2870.000000 358.000000 nan 87368.489645 -0.057 0.308 -0.660 0.547 -0.184 0.854 10.543584 1.908% 3.817146 2.428%
Caetano SC 2007 1.890000 0.160000 nan 19 1.990000 0.180000 nan 240.171507 -0.572 0.314 -1.187 0.043 -1.824 0.068 10.153173 1.838% 3.764737 2.394%
Colla M 2007 1.680000 0.270000 nan 24 1.860000 0.150000 nan 140.233880 -0.753 0.348 -1.436 -0.070 -2.162 0.031 8.235231 1.491% 3.465472 2.204%
Maller JJ 2007 3010.560000 291.400000 nan 22 3270.010000 429.570000 nan 13348.049012 -0.728 0.362 -1.438 -0.019 -2.013 0.044 7.638374 1.382% 3.355149 2.134%
Maller JJ 2007 2781.150000 376.580000 nan 23 2989.960000 252.140000 nan 17329.954869 -0.620 0.328 -1.263 0.023 -1.891 0.059 9.290532 1.682% 3.639435 2.315%
Ballmaier M (A) 2008 1116.100000 222.000000 nan 46 1272.750000 257.650000 nan 34237.736016 -0.653 0.232 -1.108 -0.197 -2.809 0.005 18.535579 3.355% 4.523214 2.877%
Keller J 2008 3.860000 0.580000 nan 23 3.780000 0.490000 nan 110.553449 0.141 0.367 -0.578 0.861 0.385 0.701 7.422876 1.343% 3.312903 2.107%
Keller J 2008 3.850000 0.300000 nan 19 3.780000 0.490000 nan 110.378955 0.180 0.380 -0.564 0.924 0.473 0.636 6.936717 1.255% 3.212419 2.043%
MacMaster FP (B) 2008 2.760000 0.270000 nan 16 3.060000 0.490000 nan 170.398995 -0.734 0.361 -1.442 -0.025 -2.030 0.042 7.658029 1.386% 3.358936 2.136%
Tae WS 2008 2589.300000 377.240000 nan 21 2811.100000 226.510000 nan 20313.009755 -0.695 0.323 -1.327 -0.062 -2.153 0.031 9.603033 1.738% 3.686429 2.344%
Bergouignan L 2009 3.950000 0.750000 nan 21 4.420000 1.040000 nan 210.906670 -0.509 0.314 -1.124 0.107 -1.619 0.105 10.138252 1.835% 3.762683 2.393%
van Eijndhoven P 2009 3620.000000 385.000000 nan 20 3716.000000 364.000000 nan 10378.377127 -0.247 0.389 -1.009 0.515 -0.635 0.525 6.615104 1.197% 3.141684 1.998%
van Eijndhoven P 2009 3600.000000 360.000000 nan 20 3716.000000 364.000000 nan 10361.290544 -0.312 0.390 -1.076 0.451 -0.802 0.423 6.584475 1.192% 3.134758 1.994%
Meisenzahl EM 2009 3.670000 0.410000 nan 92 3.830000 0.410000 nan 1380.410000 -0.389 0.136 -0.655 -0.123 -2.864 0.004 54.198887 9.810% 5.388453 3.427%
Jessen F 2009 2.060000 0.270000 nan 79 2.360000 0.290000 nan 840.280489 -1.065 0.168 -1.393 -0.736 -6.348 0.000 35.554896 6.435% 5.121456 3.257%
Kaymak SU 2009 2.850000 0.330000 nan 20 3.520000 0.330000 nan 150.330000 -1.984 0.424 -2.815 -1.152 -4.676 0.000 5.554947 1.005% 2.880589 1.832%
Kronmüller KT 2009 2.810000 0.360000 nan 13 3.190000 0.250000 nan 60.333617 -1.086 0.547 -2.159 -0.014 -1.986 0.047 3.341387 0.605% 2.144044 1.364%
Kronmüller KT 2009 2.710000 0.260000 nan 13 2.720000 0.300000 nan 100.277287 -0.035 0.427 -0.871 0.802 -0.081 0.935 5.487910 0.993% 2.862457 1.820%
Kronmüller KT 2009 3.100000 0.390000 nan 11 3.190000 0.250000 nan 60.352552 -0.242 0.524 -1.270 0.786 -0.461 0.645 3.635628 0.658% 2.261486 1.438%
Kronmüller KT 2009 2.750000 0.410000 nan 20 2.720000 0.300000 nan 100.379421 0.077 0.394 -0.696 0.849 0.195 0.845 6.435884 1.165% 3.100677 1.972%
Milne A 2009 2159.500000 260.800000 nan 28 2438.800000 307.900000 nan 14276.987392 -0.989 0.346 -1.668 -0.310 -2.856 0.004 8.333264 1.508% 3.482713 2.215%
Weber K 2009 1.740000 0.230000 nan 38 1.760000 0.260000 nan 620.249098 -0.080 0.206 -0.484 0.324 -0.387 0.699 23.541674 4.261% 4.770780 3.034%
Meta-analysis (fixed effect) 1248 1214 -0.387 0.043 -0.471 -0.304 -9.105 0.000 100%
Meta-analysis (random effects, DSL) -0.439 0.080 -0.596 -0.283 -5.507 0.000 100%
σa: 0.408817 Q: 129.649637 dof: 41.0 P-value: 0.000

Forest plot

-2 -1 0 1 2 Ashtari M 0.000000 Bremner JD 1.000000 Vakili K 2.000000 Rusch BD 3.000000 MacMillan S 4.000000 MacQueen GM 5.000000 MacQueen GM 6.000000 Posener JA 7.000000 Sheline YI 8.000000 Caetano SC 9.000000 Janssen J 10.000000 Lange C 11.000000 Lloyd AJ 12.000000 MacMaster FP (A) 13.000000 Vythilingam M 14.000000 Xia J 15.000000 Rosso IM 16.000000 Taylor WD (B) 17.000000 Saylam C 18.000000 Weniger G 19.000000 Velakoulis D 20.000000 Caetano SC 21.000000 Colla M 22.000000 Maller JJ 23.000000 Maller JJ 24.000000 Ballmaier M (A) 25.000000 Keller J 26.000000 Keller J 27.000000 MacMaster FP (B) 28.000000 Tae WS 29.000000 Bergouignan L 30.000000 van Eijndhoven P 31.000000 van Eijndhoven P 32.000000 Meisenzahl EM 33.000000 Jessen F 34.000000 Kaymak SU 35.000000 Kronmüller KT 36.000000 Kronmüller KT 37.000000 Kronmüller KT 38.000000 Kronmüller KT 39.000000 Milne A 40.000000 Weber K 41.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -1.00 -2.00 -3.00 -4.00 1.00 2.00 3.00 4.00 0.20 0.40 0.60 0.80

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.