Brede meta-analysis


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Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Ashtari M199940461742345184333774.370.061.526.1MRI13.110405084
Bremner JD2000161698226911131944337.5100000MRI1.5310618023
Vakili K200038202.610.582.60.5138.555.3MRI1.5310862809
Rusch BD200125152.290.32.20.2433.256.019.4100MRI1.51.211750892
MacMillan S200323233.170.523.260.456.511.84000100MRI1.51.512804127
MacQueen GM2003first episode20202793303.82784342.228.465.026.319.10MRI1.51.212552118
MacQueen GM2003multiple episode17172392256.72692190.135.964.724.917.50MRI1.51.212552118
Posener JA200327422948.4446.72993.9414.23355.627.3MRI1.5112505805
Sheline YI200338382203315242932650.8100.06.7MRI1.512900317
Caetano SC200431313.220.393.320.4339.277.427.911.8000100MRI1.51.515598548
Janssen J200428412.840.393.120.4564.04100.033.0461251421MRI1.51.215576058
Lange C200417172.670.53.190.3734100.029221000MRI1.51.315554576
Lloyd AJ200451392.80.530.47480.457MRI1115172942
MacMaster FP (A)200417172.540.4952.880.45416.6752.914.0660082MRI1.51.514969587
Vythilingam M20043833313241732354074160.5039MRI1.51.515231442
Xia J200422133487.2762.963710.3136.6739.545.521.45MRI1.51.215641704
Rosso IM200520246.390.7166.190.78415.3585.012.816.55000100MRI1.51.515607296
Taylor WD (B)2005135833.090.423.120.447066.746.9MRI1.5315867107
Saylam C200624242696.4194.42806.3256.833.475.024.4000100MRI1.5216395541
Weniger G200621232.70.53.20.434100.028231000MRI1.51.316740316
Velakoulis D200612873092383312238822.641.721.5MRI1.51.516461856
Caetano SC200719241.970.192.040.261331.610.34753MRI1.5117949901
Colla M200724141.780.2620.1854.562.525.3000MRI1.51.0517023001
Maller JJ200722132977.8276.563202.8487.1237.290.0MRI1.50.9417604352
Maller JJ200723172817.3239.232961.03281.637.47100.0MRI1.50.9417604352
Ballmaier M (A)200846341127.53231.121308.45245.6271.173.951.4317.73000100MRI1.51.417986679
Keller J2008psychosis23113.980.573.890.4636.547.827.630.565177017MRI31.518450931
Keller J2008no psychosis19114.090.413.890.4636.663.22723.75811042MRI31.518450931
MacMaster FP (B)200816172.840.462.990.2714.0856.311.77000100MRI1.51.517640621
Tae WS200821202658.5412.312871.9278.2141.7100.033.2100000MRI1.51.318414838
Bergouignan L200921213.930.84.51.0633.1681.023.81000MRI1.51.519071222
van Eijndhoven P200920103752442388142934.165.034.121.080MRI1.5119028381
van Eijndhoven P200920103815459388142935.870.033.43.40MRI1.5119028381
Meisenzahl EM2009921383.770.423.940.4144.651.123.5147MRI1.51.519488671
Jessen F200979842.050.322.320.348.265.8MRI1119668114
Kaymak SU200920152.720.323.40.2532100.023.1000100MRI3119756819
Kronmüller KT2009males, first episode135.530.573.30.2938.080.038.88231000MRI1.51.519800203
Kronmüller KT2009females, first episode139.52.820.362.790.4141.46100.038.8825.621000MRI1.51.519800203
Kronmüller KT2009males, recurrent115.52.970.473.30.2948.270.038.2618.721000MRI1.51.519800203
Kronmüller KT2009females, recurrent209.52.830.352.790.4145.85100.038.2622.91000MRI1.51.519800203
Weber K200938621.830.231.870.2766.1181.637.7647MRI30.920018381

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Ashtari M 1999 1742.000000 345.000000 nan 40 1843.000000 337.000000 nan 46340.737645 -0.294 0.217 -0.720 0.132 -1.351 0.177 21.157332 3.893% 5.039221 3.081%
Bremner JD 2000 982.000000 269.000000 nan 16 1113.000000 194.000000 nan 16234.517590 -0.545 0.361 -1.252 0.163 -1.509 0.131 7.675587 1.412% 3.552882 2.172%
Vakili K 2000 2.610000 0.580000 nan 38 2.600000 0.510000 nan 200.557236 0.018 0.276 -0.524 0.559 0.064 0.949 13.102951 2.411% 4.395660 2.687%
Rusch BD 2001 2.290000 0.300000 nan 25 2.200000 0.240000 nan 150.279398 0.316 0.329 -0.329 0.960 0.960 0.337 9.255077 1.703% 3.857619 2.358%
MacMillan S 2003 3.170000 0.520000 nan 23 3.260000 0.400000 nan 230.463897 -0.191 0.296 -0.770 0.389 -0.645 0.519 11.443119 2.105% 4.191691 2.563%
MacQueen GM 2003 2793.000000 303.800000 nan 20 2784.000000 342.200000 nan 20323.570147 0.027 0.316 -0.593 0.647 0.086 0.931 9.998970 1.840% 3.981070 2.434%
MacQueen GM 2003 2392.000000 256.700000 nan 17 2692.000000 190.100000 nan 17225.868214 -1.297 0.382 -2.045 -0.549 -3.398 0.001 6.867155 1.263% 3.369282 2.060%
Posener JA 2003 2948.400000 446.700000 nan 27 2993.900000 414.200000 nan 42427.105677 -0.105 0.247 -0.589 0.378 -0.427 0.670 16.411783 3.020% 4.714529 2.882%
Sheline YI 2003 2203.000000 315.000000 nan 38 2429.000000 326.000000 nan 38320.547188 -0.698 0.237 -1.162 -0.234 -2.949 0.003 17.853666 3.285% 4.826503 2.951%
Caetano SC 2004 3.220000 0.390000 nan 31 3.320000 0.430000 nan 310.410488 -0.241 0.255 -0.740 0.259 -0.943 0.345 15.381193 2.830% 4.625499 2.828%
Janssen J 2004 2.840000 0.390000 nan 28 3.120000 0.450000 nan 410.426837 -0.649 0.252 -1.142 -0.155 -2.577 0.010 15.788375 2.905% 4.661653 2.850%
Lange C 2004 2.670000 0.500000 nan 17 3.190000 0.370000 nan 170.439830 -1.154 0.374 -1.887 -0.421 -3.087 0.002 7.152492 1.316% 3.436546 2.101%
Lloyd AJ 2004 2.800000 0.500000 nan 51 3.000000 0.400000 nan 390.459496 -0.432 0.215 -0.853 -0.010 -2.005 0.045 21.583902 3.971% 5.063054 3.095%
MacMaster FP (A) 2004 2.540000 0.495000 nan 17 2.880000 0.454000 nan 170.474943 -0.699 0.355 -1.394 -0.004 -1.971 0.049 7.950810 1.463% 3.610737 2.207%
Vythilingam M 2004 3132.000000 417.000000 nan 38 3235.000000 407.000000 nan 33412.392472 -0.247 0.239 -0.715 0.221 -1.034 0.301 17.521162 3.224% 4.801868 2.936%
Xia J 2004 3487.270000 62.960000 nan 22 3710.310000 36.670000 nan 1354.877125 -3.971 0.613 -5.174 -2.769 -6.474 0.000 2.657753 0.489% 1.895964 1.159%
Rosso IM 2005 6.390000 0.716000 nan 20 6.190000 0.784000 nan 240.753998 0.260 0.304 -0.336 0.857 0.856 0.392 10.809225 1.989% 4.103540 2.509%
Taylor WD (B) 2005 3.090000 0.420000 nan 135 3.120000 0.440000 nan 830.427703 -0.070 0.140 -0.343 0.204 -0.501 0.616 51.368951 9.451% 5.860103 3.583%
Saylam C 2006 2696.400000 194.400000 nan 24 2806.300000 256.800000 nan 24227.747228 -0.475 0.293 -1.049 0.100 -1.620 0.105 11.642812 2.142% 4.218193 2.579%
Weniger G 2006 2.700000 0.500000 nan 21 3.200000 0.400000 nan 230.450397 -1.090 0.325 -1.728 -0.452 -3.350 0.001 9.440064 1.737% 3.889387 2.378%
Velakoulis D 2006 3092.000000 383.000000 nan 12 3122.000000 388.000000 nan 87387.436234 -0.077 0.308 -0.680 0.527 -0.249 0.803 10.542003 1.940% 4.064428 2.485%
Caetano SC 2007 1.970000 0.190000 nan 19 2.040000 0.260000 nan 240.231885 -0.296 0.309 -0.902 0.309 -0.959 0.337 10.479740 1.928% 4.055139 2.479%
Colla M 2007 1.780000 0.260000 nan 24 2.000000 0.180000 nan 140.234284 -0.919 0.354 -1.614 -0.225 -2.595 0.009 7.967979 1.466% 3.614273 2.210%
Maller JJ 2007 2977.800000 276.560000 nan 22 3202.800000 487.120000 nan 13367.366749 -0.598 0.358 -1.300 0.103 -1.672 0.095 7.803795 1.436% 3.580108 2.189%
Maller JJ 2007 2817.300000 239.230000 nan 23 2961.030000 281.600000 nan 17257.919755 -0.546 0.326 -1.186 0.093 -1.674 0.094 9.395110 1.729% 3.881735 2.373%
Ballmaier M (A) 2008 1127.530000 231.120000 nan 46 1308.450000 245.620000 nan 34237.362741 -0.755 0.234 -1.214 -0.296 -3.222 0.001 18.216039 3.352% 4.852599 2.967%
Keller J 2008 3.980000 0.570000 nan 23 3.890000 0.460000 nan 110.538046 0.163 0.367 -0.556 0.883 0.445 0.656 7.416691 1.365% 3.496388 2.138%
Keller J 2008 4.090000 0.410000 nan 19 3.890000 0.460000 nan 110.428527 0.454 0.384 -0.299 1.207 1.182 0.237 6.779796 1.247% 3.348115 2.047%
MacMaster FP (B) 2008 2.840000 0.460000 nan 16 2.990000 0.270000 nan 170.374183 -0.391 0.352 -1.081 0.299 -1.111 0.267 8.067427 1.484% 3.634597 2.222%
Tae WS 2008 2658.500000 412.310000 nan 21 2871.900000 278.210000 nan 20353.394020 -0.592 0.320 -1.219 0.035 -1.851 0.064 9.770385 1.798% 3.944329 2.411%
Bergouignan L 2009 3.930000 0.800000 nan 21 4.500000 1.060000 nan 210.939042 -0.596 0.316 -1.215 0.024 -1.884 0.060 10.010255 1.842% 3.982858 2.435%
van Eijndhoven P 2009 3752.000000 442.000000 nan 20 3881.000000 429.000000 nan 10437.863522 -0.287 0.389 -1.050 0.476 -0.736 0.462 6.597328 1.214% 3.303001 2.019%
van Eijndhoven P 2009 3815.000000 459.000000 nan 20 3881.000000 429.000000 nan 10449.575514 -0.143 0.388 -0.903 0.617 -0.368 0.713 6.649314 1.223% 3.315981 2.027%
Meisenzahl EM 2009 3.770000 0.420000 nan 92 3.940000 0.410000 nan 1380.414020 -0.409 0.136 -0.676 -0.143 -3.010 0.003 54.093828 9.953% 5.893973 3.603%
Jessen F 2009 2.050000 0.320000 nan 79 2.320000 0.300000 nan 840.309851 -0.867 0.164 -1.189 -0.546 -5.285 0.000 37.136543 6.833% 5.614631 3.433%
Kaymak SU 2009 2.720000 0.320000 nan 20 3.400000 0.250000 nan 150.292357 -2.273 0.447 -3.149 -1.397 -5.084 0.000 5.004713 0.921% 2.849083 1.742%
Kronmüller KT 2009 3.000000 0.570000 nan 13 3.300000 0.290000 nan 60.509144 -0.562 0.519 -1.580 0.456 -1.082 0.279 3.709354 0.682% 2.376611 1.453%
Kronmüller KT 2009 2.820000 0.360000 nan 13 2.790000 0.410000 nan 100.381528 0.076 0.427 -0.761 0.913 0.177 0.859 5.484239 1.009% 2.998329 1.833%
Kronmüller KT 2009 2.970000 0.470000 nan 11 3.300000 0.290000 nan 60.422427 -0.740 0.543 -1.804 0.324 -1.364 0.173 3.395222 0.625% 2.243611 1.372%
Kronmüller KT 2009 2.830000 0.350000 nan 20 2.790000 0.410000 nan 100.369587 0.105 0.394 -0.668 0.878 0.267 0.790 6.431701 1.183% 3.260959 1.994%
Weber K 2009 1.830000 0.230000 nan 38 1.870000 0.270000 nan 620.255634 -0.155 0.206 -0.560 0.249 -0.753 0.452 23.490548 4.322% 5.161324 3.155%
Meta-analysis (fixed effect) 1220 1200 -0.408 0.043 -0.492 -0.324 -9.519 0.000 100%
Meta-analysis (random effects, DSL) -0.448 0.078 -0.602 -0.295 -5.736 0.000 100%
σa: 0.388817 Q: 118.777037 dof: 40.0 P-value: 0.000

Forest plot

-2 -1 0 1 2 Ashtari M 0.000000 Bremner JD 1.000000 Vakili K 2.000000 Rusch BD 3.000000 MacMillan S 4.000000 MacQueen GM 5.000000 MacQueen GM 6.000000 Posener JA 7.000000 Sheline YI 8.000000 Caetano SC 9.000000 Janssen J 10.000000 Lange C 11.000000 Lloyd AJ 12.000000 MacMaster FP (A) 13.000000 Vythilingam M 14.000000 Xia J 15.000000 Rosso IM 16.000000 Taylor WD (B) 17.000000 Saylam C 18.000000 Weniger G 19.000000 Velakoulis D 20.000000 Caetano SC 21.000000 Colla M 22.000000 Maller JJ 23.000000 Maller JJ 24.000000 Ballmaier M (A) 25.000000 Keller J 26.000000 Keller J 27.000000 MacMaster FP (B) 28.000000 Tae WS 29.000000 Bergouignan L 30.000000 van Eijndhoven P 31.000000 van Eijndhoven P 32.000000 Meisenzahl EM 33.000000 Jessen F 34.000000 Kaymak SU 35.000000 Kronmüller KT 36.000000 Kronmüller KT 37.000000 Kronmüller KT 38.000000 Kronmüller KT 39.000000 Weber K 40.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -1.00 -2.00 -3.00 -4.00 1.00 2.00 3.00 4.00 0.20 0.40 0.60 0.80

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.