Brede meta-analysis


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Column names Number Mean SD Events
Experimentals:
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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Ashtari M199940463487662369759774.370.061.526.1MRI13.110405084
Bremner JD200016161922452.93288692279419.66558114337.5100.00.00.00.0MRI1.5310618023
Vakili K200038205.251.0720541035.060.84532833938.555.3MRI1.5310862809
Rusch BD200125154.460.531413214.330.48392148133.256.019.4100.0MRI1.51.211750892
MacMillan S200323236.320.8642800476.50.7969943541456.511.840.00.00.0100.0MRI1.51.512804127
MacQueen GM2003first episode20205531573.85916225545674.185262428.465.026.319.10.0MRI1.51.212552118
MacQueen GM2003multiple episode17174773503.019945395416.983033235.964.724.917.50.0MRI1.51.212552118
Posener JA200327425494.4796.50783055468.9734.10596513355.627.3MRI1.5112505805
Sheline YI200338384374598.61924464850610.957281650.8100.06.7MRI1.512900317
Caetano SC200431316.540.8258450226.690.80638700439.277.427.9258064511.796774190.00.00.0100.0MRI1.51.515598548
Janssen J200428415.940.76.320.9364.04100.033.0461251421MRI1.51.215576058
Lange C200417175.460.836.190.7134100.029221000MRI1.51.315554576
Lloyd AJ200451395.50.8544003755.80.7589466387480.456.98235294MRI1115172942
MacMaster FP (A)200417175.070.8224949855.930.86140443516.6752.914.065.90.00.082.4MRI1.51.514969587
Vythilingam M20043833321938032853894160.5039MRI1.51.515231442
Xia J200422136597.13139.09589357062.3178.0320828939.545.521.45MRI1.51.215641704
Hickie I (A)200551205.90.66.61.153.586.338.424.9MRI1.51.515738499
Rosso IM2005202412.961.47612.451.37215.3585.012.816.55000100MRI1.51.515607296
Taylor WD (B)2005135836.040.796.090.847066.746.9MRI1.5315867107
Saylam C200624245335.1421.19255455593480.03976533.475.024.40.00.00.0100.0MRI1.5216395541
Velakoulis D200612875941782.88607095992707.781322222.641.721.5MRI1.51.516461856
Weniger G200621235.40.8544003756.20.85440037534100.02823100.00.0MRI1.51.316740316
Caetano SC200719243.860.3321746534.030.4181865611331.610.347.452.6MRI1.5117949901
Colla M200724143.460.523.860.3254.562.525.3000MRI1.51.0517023001
Maller JJ2007males22135988.36538.83460176472.81869.838893637.290.0MRI1.50.9417604352
Maller JJ2007females23175598.45585.8210165950.99506.43591737.47100.0MRI1.50.9417604352
Andreescu C200871320.750.110.830.1372.269.052.318.3171MRI1.51.518075490
Ballmaier M (A)200846342243.63429.87705032581.2477.45899971.173.951.4317.730.00.00.0100.0MRI1.51.417986679
Keller J2008psychosis23117.841.0909903767.670.90129906236.547.827.630.565.217.470.017.4MRI31.518450931
Keller J2008no psychosis19117.940.6744627497.670.90129906236.663.22723.757.910.50.042.1MRI31.518450931
MacMaster FP (B)200816175.60.6951402746.050.72434798314.0856.311.770.00.00.0100.0MRI1.51.517640621
Tae WS200821205247.8749.1149935683479.098465441.7100.033.2100.00.00.00.0MRI1.51.318414838
Bergouignan L200921217.881.4705441178.921.99224496533.1681.023.8100.00.0MRI1.51.519071222
Jessen F200979844.110.5599464264.680.55973207948.265.8MRI1119668114
Kaymak SU200920155.570.6166522526.920.55081757432100.023.10.00.00.0100.0MRI3119756819
Kronmüller KT2009males, first episode135.55.810.96.490.4938.080.038.8823.0100.00.0MRI1.51.519800203
Kronmüller KT2009females, first episode139.55.520.575.510.6641.46100.038.8825.6100.00.0MRI1.51.519800203
Kronmüller KT2009males, recurrent115.56.070.856.490.4948.270.038.2618.7100.00.0MRI1.51.519800203
Kronmüller KT2009females, recurrent209.55.590.735.510.6645.85100.038.2622.9100.00.0MRI1.51.519800203
Meisenzahl EM2009921387.440.7874134877.770.77792030444.651.123.514.16.5MRI1.51.519488671
van Eijndhoven P2009depressed20107372784.76811867597752.586606334.165.034.121.080.0MRI1.5119028381
van Eijndhoven P2009remitted20107415777.60208337597752.586606335.870.033.43.40.0MRI1.5119028381
Weber K200938623.580.453.630.5266.1181.637.7647.4MRI30.920018381
Köhler S201035295.60.95.80.874.180.080.00.0MRI1120118461

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Ashtari M 1999 3487.000000 662.000000 nan 40 3697.000000 597.000000 nan 46628.015781 -0.331 0.218 -0.758 0.095 -1.522 0.128 21.093362 3.562% 4.939370 2.826%
Bremner JD 2000 1922.000000 452.932887 nan 16 2279.000000 419.665581 nan 16436.616193 -0.797 0.369 -1.521 -0.073 -2.159 0.031 7.335688 1.239% 3.432103 1.964%
Vakili K 2000 5.250000 1.072054 nan 38 5.060000 0.845328 nan 201.000902 0.187 0.277 -0.355 0.730 0.676 0.499 13.047988 2.204% 4.316171 2.470%
Rusch BD 2001 4.460000 0.531413 nan 25 4.330000 0.483921 nan 150.514427 0.248 0.328 -0.395 0.890 0.755 0.450 9.300827 1.571% 3.808595 2.179%
MacMillan S 2003 6.320000 0.864280 nan 23 6.500000 0.796994 nan 230.831318 -0.213 0.296 -0.793 0.367 -0.719 0.472 11.429237 1.930% 4.123004 2.359%
MacQueen GM 2003 5531.000000 573.859162 nan 20 5545.000000 674.185262 nan 20626.035185 -0.022 0.316 -0.642 0.598 -0.069 0.945 9.999334 1.689% 3.920748 2.243%
MacQueen GM 2003 4773.000000 503.019940 nan 17 5395.000000 416.983033 nan 17462.008609 -1.314 0.383 -2.064 -0.565 -3.436 0.001 6.831172 1.154% 3.317471 1.898%
Posener JA 2003 5494.400000 796.507830 nan 27 5468.900000 734.105965 nan 42758.931074 0.033 0.247 -0.450 0.517 0.135 0.893 16.432492 2.775% 4.631737 2.650%
Sheline YI 2003 4374.000000 598.619245 nan 38 4850.000000 610.957282 nan 38604.819725 -0.779 0.238 -1.246 -0.312 -3.267 0.001 17.592523 2.971% 4.719452 2.700%
Caetano SC 2004 6.540000 0.825845 nan 31 6.690000 0.806387 nan 310.816174 -0.181 0.255 -0.680 0.317 -0.713 0.476 15.432158 2.606% 4.548630 2.603%
Janssen J 2004 5.940000 0.700000 nan 28 6.320000 0.930000 nan 410.844879 -0.445 0.248 -0.931 0.042 -1.791 0.073 16.227327 2.741% 4.615290 2.641%
Lange C 2004 5.460000 0.830000 nan 17 6.190000 0.710000 nan 170.772334 -0.923 0.363 -1.634 -0.211 -2.542 0.011 7.586492 1.281% 3.486022 1.995%
Lloyd AJ 2004 5.500000 0.854400 nan 51 5.800000 0.758947 nan 390.814555 -0.365 0.215 -0.786 0.055 -1.702 0.089 21.728014 3.670% 4.973387 2.846%
MacMaster FP (A) 2004 5.070000 0.822495 nan 17 5.930000 0.861404 nan 170.842174 -0.997 0.366 -1.715 -0.279 -2.722 0.006 7.452549 1.259% 3.457468 1.978%
Vythilingam M 2004 3219.000000 380.000000 nan 38 3285.000000 389.000000 nan 33384.200129 -0.170 0.238 -0.637 0.297 -0.713 0.476 17.595079 2.972% 4.719636 2.701%
Xia J 2004 6597.130000 139.095893 nan 22 7062.310000 78.032083 nan 13120.525251 -3.771 0.593 -4.933 -2.609 -6.363 0.000 2.846384 0.481% 1.974842 1.130%
Hickie I (A) 2005 5.900000 0.600000 nan 51 6.600000 1.100000 nan 200.770752 -0.898 0.275 -1.437 -0.359 -3.267 0.001 13.223250 2.233% 4.335178 2.481%
Rosso IM 2005 12.960000 1.476000 nan 20 12.450000 1.372000 nan 241.419991 0.353 0.305 -0.246 0.951 1.155 0.248 10.727387 1.812% 4.027937 2.305%
Taylor WD (B) 2005 6.040000 0.790000 nan 135 6.090000 0.840000 nan 830.809345 -0.062 0.140 -0.335 0.212 -0.441 0.659 51.375705 8.677% 5.730293 3.279%
Saylam C 2006 5335.100000 421.192555 nan 24 5593.000000 480.039765 nan 24451.575765 -0.562 0.295 -1.140 0.016 -1.905 0.057 11.505576 1.943% 4.132896 2.365%
Velakoulis D 2006 5941.000000 782.886071 nan 12 5992.000000 707.781322 nan 87716.694122 -0.071 0.308 -0.674 0.533 -0.229 0.819 10.542539 1.781% 4.001593 2.290%
Weniger G 2006 5.400000 0.854400 nan 21 6.200000 0.854400 nan 230.854400 -0.920 0.319 -1.544 -0.295 -2.884 0.004 9.837660 1.661% 3.895645 2.229%
Caetano SC 2007 3.860000 0.332175 nan 19 4.030000 0.418187 nan 240.382812 -0.436 0.311 -1.045 0.174 -1.402 0.161 10.337989 1.746% 3.971764 2.273%
Colla M 2007 3.460000 0.520000 nan 24 3.860000 0.320000 nan 140.457967 -0.855 0.352 -1.545 -0.165 -2.430 0.015 8.075637 1.364% 3.585824 2.052%
Maller JJ 2007 5988.360000 538.834602 nan 22 6472.810000 869.838894 nan 13678.157792 -0.698 0.361 -1.405 0.009 -1.934 0.053 7.679275 1.297% 3.505484 2.006%
Maller JJ 2007 5598.450000 585.821016 nan 23 5950.990000 506.435917 nan 17553.784472 -0.624 0.328 -1.267 0.019 -1.901 0.057 9.285052 1.568% 3.805947 2.178%
Andreescu C 2008 0.750000 0.110000 nan 71 0.830000 0.130000 nan 320.116504 -0.682 0.218 -1.110 -0.254 -3.121 0.002 20.973527 3.542% 4.932770 2.822%
Ballmaier M (A) 2008 2243.630000 429.877050 nan 46 2581.200000 477.458999 nan 34450.621461 -0.742 0.234 -1.201 -0.283 -3.170 0.002 18.258456 3.084% 4.766085 2.727%
Keller J 2008 7.840000 1.090990 nan 23 7.670000 0.901299 nan 111.035452 0.160 0.367 -0.559 0.880 0.437 0.662 7.417585 1.253% 3.449924 1.974%
Keller J 2008 7.940000 0.674463 nan 19 7.670000 0.901299 nan 110.763254 0.344 0.382 -0.404 1.093 0.901 0.367 6.858071 1.158% 3.323802 1.902%
MacMaster FP (B) 2008 5.600000 0.695140 nan 16 6.050000 0.724348 nan 170.710365 -0.618 0.358 -1.319 0.083 -1.728 0.084 7.818890 1.321% 3.534292 2.022%
Tae WS 2008 5247.800000 749.114993 nan 21 5683.000000 479.098465 nan 20632.144030 -0.675 0.322 -1.307 -0.044 -2.096 0.036 9.636839 1.628% 3.863761 2.211%
Bergouignan L 2009 7.880000 1.470544 nan 21 8.920000 1.992245 nan 211.750934 -0.583 0.316 -1.202 0.036 -1.846 0.065 10.030129 1.694% 3.925474 2.246%
Jessen F 2009 4.110000 0.559946 nan 79 4.680000 0.559732 nan 840.559836 -1.013 0.167 -1.340 -0.687 -6.079 0.000 35.982484 6.077% 5.469323 3.129%
Kaymak SU 2009 5.570000 0.616652 nan 20 6.920000 0.550818 nan 150.589621 -2.237 0.444 -3.108 -1.367 -5.037 0.000 5.070078 0.856% 2.838632 1.624%
Kronmüller KT 2009 5.810000 0.900000 nan 13 6.490000 0.490000 nan 60.809057 -0.802 0.530 -1.840 0.237 -1.513 0.130 3.561096 0.601% 2.294319 1.313%
Kronmüller KT 2009 5.520000 0.570000 nan 13 5.510000 0.660000 nan 100.608933 0.016 0.427 -0.821 0.852 0.037 0.970 5.488686 0.927% 2.965250 1.697%
Kronmüller KT 2009 6.070000 0.850000 nan 11 6.490000 0.490000 nan 60.756829 -0.526 0.533 -1.570 0.518 -0.987 0.324 3.524471 0.595% 2.279061 1.304%
Kronmüller KT 2009 5.590000 0.730000 nan 20 5.510000 0.660000 nan 100.709102 0.110 0.394 -0.663 0.883 0.278 0.781 6.430925 1.086% 3.220142 1.843%
Meisenzahl EM 2009 7.440000 0.787413 nan 92 7.770000 0.777920 nan 1380.781723 -0.421 0.136 -0.687 -0.154 -3.093 0.002 54.032130 9.125% 5.761889 3.297%
van Eijndhoven P 2009 7372.000000 784.768119 nan 20 7597.000000 752.586606 nan 10774.569890 -0.283 0.389 -1.046 0.480 -0.726 0.468 6.599238 1.115% 3.261799 1.866%
van Eijndhoven P 2009 7415.000000 777.602083 nan 20 7597.000000 752.586606 nan 10769.650069 -0.230 0.389 -0.992 0.532 -0.592 0.554 6.621829 1.118% 3.267308 1.870%
Weber K 2009 3.580000 0.450000 nan 38 3.630000 0.520000 nan 620.494737 -0.100 0.206 -0.504 0.304 -0.486 0.627 23.530977 3.974% 5.062167 2.897%
Köhler S 2010 5.600000 0.900000 nan 35 5.800000 0.800000 nan 290.856286 -0.231 0.252 -0.725 0.263 -0.916 0.360 15.748681 2.660% 4.575736 2.618%
Meta-analysis (fixed effect) 1377 1281 -0.430 0.041 -0.510 -0.349 -10.454 0.000 100%
Meta-analysis (random effects, DSL) -0.470 0.076 -0.618 -0.322 -6.216 0.000 100%
σa: 0.393760 Q: 131.410434 dof: 43.0 P-value: 0.000

Forest plot

-2 -1 0 1 2 Ashtari M 0.000000 Bremner JD 1.000000 Vakili K 2.000000 Rusch BD 3.000000 MacMillan S 4.000000 MacQueen GM 5.000000 MacQueen GM 6.000000 Posener JA 7.000000 Sheline YI 8.000000 Caetano SC 9.000000 Janssen J 10.000000 Lange C 11.000000 Lloyd AJ 12.000000 MacMaster FP (A) 13.000000 Vythilingam M 14.000000 Xia J 15.000000 Hickie I (A) 16.000000 Rosso IM 17.000000 Taylor WD (B) 18.000000 Saylam C 19.000000 Velakoulis D 20.000000 Weniger G 21.000000 Caetano SC 22.000000 Colla M 23.000000 Maller JJ 24.000000 Maller JJ 25.000000 Andreescu C 26.000000 Ballmaier M (A) 27.000000 Keller J 28.000000 Keller J 29.000000 MacMaster FP (B) 30.000000 Tae WS 31.000000 Bergouignan L 32.000000 Jessen F 33.000000 Kaymak SU 34.000000 Kronmüller KT 35.000000 Kronmüller KT 36.000000 Kronmüller KT 37.000000 Kronmüller KT 38.000000 Meisenzahl EM 39.000000 van Eijndhoven P 40.000000 van Eijndhoven P 41.000000 Weber K 42.000000 Köhler S 43.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -1.00 -2.00 -3.00 -4.00 1.00 2.00 3.00 4.00 0.20 0.40 0.60 0.80

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.