Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Scott ML198310109.453.414.162.9139.15CT6574534
Iacono WG198816446.362.966.392.7622.631.3CT83381925
Pearlson GD19891131114.318.62.787054.512.5CT82798631
Andreasen NC199026756.223.175.752.5137.2657.724.85785267CT82356874
Harvey I19905504.485.64.682.7nsCT102320698
Lewine RR199112688.92.98.81.9ns000100MRI181715677
Lauer CJ199214125.33.83.130.3940.7000100CT101486107
Wurthmann C199534429.763.048.182.9170.782.420CT7480387
Elkis H1996males8175.311.645.562.8438.70.029.7CT88876012
Elkis H1996females16236.651.845.522.4338.7100.029.7CT88876012
Marchesi C1996111111.11.68.71.864.80.000CT8886297
Pantel J1997191310.153.87.272.372.478.964.226.7MRI1.51.259089060
Parashos IA1998723827.2415.2526.2916.9155.462.538.5MRI1.559870413
McIntosh AM2001929130626267.702051100415126.01209543.5655.6MRI11.8811200955
Pujol J2002573723.113.814.3760.859.65028.8MRI1.52.311771978
Lloyd AJ2004513925.411.8802356920.811.744360357480.457MRI1115172942

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Scott ML 1983 9.450000 3.410000 nan 10 4.160000 2.910000 nan 103.169874 1.598 0.529 0.562 2.635 3.023 0.003 3.577382 1.975% 2.962547 2.957%
Iacono WG 1988 6.360000 2.960000 nan 16 6.390000 2.760000 nan 442.813088 -0.011 0.292 -0.583 0.562 -0.036 0.971 11.733197 6.477% 6.981210 6.967%
Pearlson GD 1989 11.000000 4.310000 nan 11 8.600000 2.780000 nan 313.231149 0.729 0.361 0.022 1.436 2.020 0.043 7.683791 4.242% 5.314697 5.304%
Andreasen NC 1990 6.220000 3.170000 nan 26 5.750000 2.510000 nan 752.691982 0.173 0.228 -0.273 0.620 0.760 0.447 19.249454 10.627% 9.093975 9.076%
Harvey I 1990 4.480000 5.600000 nan 5 4.680000 2.700000 nan 503.017715 -0.065 0.469 -0.985 0.854 -0.139 0.889 4.544591 2.509% 3.596408 3.589%
Lewine RR 1991 8.900000 2.900000 nan 12 8.800000 1.900000 nan 682.070489 0.048 0.313 -0.566 0.662 0.153 0.879 10.198435 5.630% 6.407478 6.395%
Lauer CJ 1992 5.300000 3.800000 nan 14 3.130000 0.390000 nan 122.809160 0.748 0.409 -0.054 1.550 1.828 0.068 5.972075 3.297% 4.435389 4.426%
Wurthmann C 1995 9.760000 3.040000 nan 34 8.180000 2.910000 nan 422.968676 0.527 0.235 0.067 0.987 2.243 0.025 18.133360 10.011% 8.837016 8.819%
Elkis H 1996 5.310000 1.640000 nan 8 5.560000 2.840000 nan 172.535631 -0.095 0.429 -0.936 0.745 -0.222 0.824 5.433620 3.000% 4.131331 4.123%
Elkis H 1996 6.650000 1.840000 nan 16 5.520000 2.430000 nan 232.209878 0.501 0.331 -0.148 1.150 1.513 0.130 9.127711 5.039% 5.967659 5.956%
Marchesi C 1996 11.100000 1.600000 nan 11 8.700000 1.800000 nan 111.702939 1.356 0.482 0.410 2.301 2.811 0.005 4.297190 2.372% 3.439693 3.433%
Pantel J 1997 10.150000 3.800000 nan 19 7.270000 2.300000 nan 133.283291 0.855 0.378 0.115 1.595 2.264 0.024 7.013486 3.872% 4.985148 4.975%
Parashos IA 1998 27.240000 15.250000 nan 72 26.290000 16.910000 nan 3815.838308 0.060 0.201 -0.334 0.453 0.297 0.766 24.862384 13.725% 10.179693 10.159%
McIntosh AM 2001 13062.000000 6267.702051 nan 9 10041.000000 5126.012095 nan 295400.619080 0.548 0.387 -0.211 1.307 1.414 0.157 6.666817 3.680% 4.807461 4.798%
Pujol J 2002 23.100000 13.800000 nan 57 14.300000 7.000000 nan 3711.622991 0.751 0.218 0.323 1.179 3.438 0.001 20.963673 11.573% 9.459400 9.440%
Lloyd AJ 2004 25.400000 11.880236 nan 51 20.800000 11.744360 nan 3911.821754 0.386 0.215 -0.035 0.807 1.797 0.072 21.685592 11.972% 9.603661 9.584%
Meta-analysis (fixed effect) 371 539 0.408 0.074 0.262 0.553 5.488 0.000 100%
Meta-analysis (random effects, DSL) 0.436 0.100 0.241 0.632 4.368 0.000 100%
σa: 0.240860 Q: 24.604918 dof: 15.0 P-value: 0.056

Forest plot

-2 -1 0 1 2 Scott ML 0.000000 Iacono WG 1.000000 Pearlson GD 2.000000 Andreasen NC 3.000000 Harvey I 4.000000 Lewine RR 5.000000 Lauer CJ 6.000000 Wurthmann C 7.000000 Elkis H 8.000000 Elkis H 9.000000 Marchesi C 10.000000 Pantel J 11.000000 Parashos IA 12.000000 McIntosh AM 13.000000 Pujol J 14.000000 Lloyd AJ 15.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.50 -1.00 -1.50 -2.00 0.50 1.00 1.50 2.00 0.20 0.40 0.60 0.80

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.