Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Scott ML198310109.453.414.162.9139.15CT6574534
Iacono WG198816446.362.966.392.7622.631.3CT83381925
Pearlson GD19891131114.318.62.787054.512.5CT82798631
Andreasen NC199026756.223.175.752.5137.2657.724.85785267CT82356874
Harvey I19905504.485.64.682.7nsCT102320698
Lauer CJ199214125.33.83.130.3940.7000100CT101486107
Wurthmann C199534429.763.048.182.9170.782.420CT7480387
Elkis H1996males8175.311.645.562.8438.70.029.7CT88876012
Elkis H1996females16236.651.845.522.4338.7100.029.7CT88876012
Marchesi C1996111111.11.68.71.864.80.000CT8886297

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Scott ML 1983 9.450000 3.410000 nan 10 4.160000 2.910000 nan 103.169874 1.598 0.529 0.562 2.635 3.023 0.003 3.577382 3.986% 2.682520 5.958%
Iacono WG 1988 6.360000 2.960000 nan 16 6.390000 2.760000 nan 442.813088 -0.011 0.292 -0.583 0.562 -0.036 0.971 11.733197 13.073% 5.602928 12.445%
Pearlson GD 1989 11.000000 4.310000 nan 11 8.600000 2.780000 nan 313.231149 0.729 0.361 0.022 1.436 2.020 0.043 7.683791 8.561% 4.476397 9.943%
Andreasen NC 1990 6.220000 3.170000 nan 26 5.750000 2.510000 nan 752.691982 0.173 0.228 -0.273 0.620 0.760 0.447 19.249454 21.447% 6.887083 15.298%
Harvey I 1990 4.480000 5.600000 nan 5 4.680000 2.700000 nan 503.017715 -0.065 0.469 -0.985 0.854 -0.139 0.889 4.544591 5.063% 3.191914 7.090%
Lauer CJ 1992 5.300000 3.800000 nan 14 3.130000 0.390000 nan 122.809160 0.748 0.409 -0.054 1.550 1.828 0.068 5.972075 6.654% 3.835888 8.520%
Wurthmann C 1995 9.760000 3.040000 nan 34 8.180000 2.910000 nan 422.968676 0.527 0.235 0.067 0.987 2.243 0.025 18.133360 20.204% 6.738689 14.968%
Elkis H 1996 5.310000 1.640000 nan 8 5.560000 2.840000 nan 172.535631 -0.095 0.429 -0.936 0.745 -0.222 0.824 5.433620 6.054% 3.606343 8.010%
Elkis H 1996 6.650000 1.840000 nan 16 5.520000 2.430000 nan 232.209878 0.501 0.331 -0.148 1.150 1.513 0.130 9.127711 10.170% 4.930813 10.952%
Marchesi C 1996 11.100000 1.600000 nan 11 8.700000 1.800000 nan 111.702939 1.356 0.482 0.410 2.301 2.811 0.005 4.297190 4.788% 3.067861 6.814%
Meta-analysis (fixed effect) 151 315 0.425 0.106 0.218 0.632 4.025 0.000 100%
Meta-analysis (random effects, DSL) 0.470 0.149 0.178 0.763 3.157 0.002 100%
σa: 0.305368 Q: 16.230175 dof: 9.0 P-value: 0.062

Forest plot

-2 -1 0 1 2 Scott ML 0.000000 Iacono WG 1.000000 Pearlson GD 2.000000 Andreasen NC 3.000000 Harvey I 4.000000 Lauer CJ 5.000000 Wurthmann C 6.000000 Elkis H 7.000000 Elkis H 8.000000 Marchesi C 9.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.50 -1.00 -1.50 -2.00 0.50 1.00 1.50 2.00 0.20 0.40 0.60 0.80

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.