Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Lewine RR199112688.92.98.81.9ns000100MRI181715677
Pantel J1997191310.153.87.272.372.478.964.226.7MRI1.51.259089060
Parashos IA1998723827.2415.2526.2916.9155.462.538.5MRI1.559870413
McIntosh AM2001929130626267.702051100415126.01209543.5655.6MRI11.8811200955
Pujol J2002573723.113.814.3760.859.65028.8MRI1.52.311771978
Lloyd AJ2004513925.411.8802356920.811.744360357480.457MRI1115172942

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Lewine RR 1991 8.900000 2.900000 nan 12 8.800000 1.900000 nan 682.070489 0.048 0.313 -0.566 0.662 0.153 0.879 10.198435 11.159% 6.950434 13.748%
Pantel J 1997 10.150000 3.800000 nan 19 7.270000 2.300000 nan 133.283291 0.855 0.378 0.115 1.595 2.264 0.024 7.013486 7.674% 5.307740 10.499%
Parashos IA 1998 27.240000 15.250000 nan 72 26.290000 16.910000 nan 3815.838308 0.060 0.201 -0.334 0.453 0.297 0.766 24.862384 27.205% 11.622088 22.988%
McIntosh AM 2001 13062.000000 6267.702051 nan 9 10041.000000 5126.012095 nan 295400.619080 0.548 0.387 -0.211 1.307 1.414 0.157 6.666817 7.295% 5.106776 10.101%
Pujol J 2002 23.100000 13.800000 nan 57 14.300000 7.000000 nan 3711.622991 0.751 0.218 0.323 1.179 3.438 0.001 20.963673 22.939% 10.692532 21.150%
Lloyd AJ 2004 25.400000 11.880236 nan 51 20.800000 11.744360 nan 3911.821754 0.386 0.215 -0.035 0.807 1.797 0.072 21.685592 23.729% 10.877224 21.515%
Meta-analysis (fixed effect) 220 224 0.391 0.105 0.186 0.596 3.737 0.000 100%
Meta-analysis (random effects, DSL) 0.407 0.141 0.132 0.683 2.895 0.004 100%
σa: 0.214060 Q: 8.322510 dof: 5.0 P-value: 0.139

Forest plot

-2 -1 0 1 2 Lewine RR 0.000000 Pantel J 1.000000 Parashos IA 2.000000 McIntosh AM 3.000000 Pujol J 4.000000 Lloyd AJ 5.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.30 -0.60 -0.90 -1.20 0.30 0.60 0.90 1.20 0.10 0.20 0.30 0.40

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.