Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Janssen J2004284112.634.5613.13.3364.04100.033.046125021MRI1.51.215576058
Lacerda AL2004313412.412.2213.43.639.2677.427.9414.070100MRI1.51.514960287
Lavretsky H2004females32200.01720.00310.01940.00270.5100.048.5000100MRI1.51.415545334
Lavretsky H2004males9210.01670.00140.01880.001770.50.048.5000100MRI1.51.415545334
Taylor WD2007226144133.113.82.97066.445.40MRI1.5317335636
Chen HH2008272616.54.215.63.314.463.011.7520.1000100MRI1.51.519108659
Andreescu C200871321.890.272.080.3872.269.052.318.3171MRI1.51.518075490

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Janssen J 2004 12.630000 4.560000 nan 28 13.100000 3.330000 nan 413.872951 -0.120 0.245 -0.601 0.361 -0.489 0.625 16.607108 9.722% 7.831913 14.446%
Lacerda AL 2004 12.410000 2.220000 nan 31 13.400000 3.600000 nan 343.022487 -0.324 0.250 -0.814 0.166 -1.294 0.196 15.992968 9.362% 7.692602 14.189%
Lavretsky H 2004 0.017200 0.003100 nan 32 0.019400 0.002000 nan 200.002735 -0.792 0.296 -1.373 -0.212 -2.674 0.007 11.391868 6.669% 6.441246 11.881%
Lavretsky H 2004 0.016700 0.001400 nan 9 0.018800 0.001700 nan 210.001620 -1.261 0.435 -2.114 -0.409 -2.899 0.004 5.283933 3.093% 3.895287 7.185%
Taylor WD 2007 13.000000 3.100000 nan 226 13.800000 2.900000 nan 1443.023854 -0.264 0.107 -0.474 -0.054 -2.466 0.014 87.226259 51.062% 12.669136 23.368%
Chen HH 2008 16.500000 4.200000 nan 27 15.600000 3.300000 nan 263.785654 0.234 0.276 -0.306 0.775 0.849 0.396 13.147912 7.697% 6.967415 12.851%
Andreescu C 2008 1.890000 0.270000 nan 71 2.080000 0.380000 nan 320.307970 -0.612 0.217 -1.038 -0.186 -2.818 0.005 21.174255 12.395% 8.718798 16.081%
Meta-analysis (fixed effect) 424 318 -0.327 0.077 -0.476 -0.177 -4.267 0.000 100%
Meta-analysis (random effects, DSL) -0.378 0.136 -0.644 -0.112 -2.784 0.005 100%
σa: 0.259745 Q: 14.002550 dof: 6.0 P-value: 0.030

Forest plot

-2 -1 0 1 2 Janssen J 0.000000 Lacerda AL 1.000000 Lavretsky H 2.000000 Lavretsky H 3.000000 Taylor WD 4.000000 Chen HH 5.000000 Andreescu C 6.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.50 -1.00 -1.50 -2.00 0.50 1.00 1.50 2.00 0.20 0.40 0.60 0.80

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.