Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Greenwald BS199648391.850.831.690.8974.668.862.425.9MRI1108780429
Keshavan MS199619192.110.9421.11084.253.8MRI18723302
Kumar A199728291.880.980.870.9674.260.719.57MRI1.559169241
Lenze EJ (A)199924240.730.830.630.6652.7100.067MRI1.510518173
Lloyd AJ2004early onset2319.53.21.712.91.7572.795.738.7MRI1115172942
Lloyd AJ2004late onset2819.53.61.592.91.7575.167.972MRI1115172942
Iosifescu DV2005low folate1517.50.610.50.450.5640.6113.327.819.9100MRI1.5516298109
Iosifescu DV2005normal folate3517.50.540.60.450.5640.648.627.819.9100MRI1.5516298109
Lin HF200537181.520.80.880.8672.262.263.721.9MRI3516248124
Naish JH2006treatment responsive21113.054.232.721.727157.1MRI1.5316894588
Naish JH2006treatment resistant8114.32.712.721.7271150.0MRI1.5316894588
Weber K200938620.70.950.891.1366.1181.637.7647MRI30.920018381

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Greenwald BS 1996 1.850000 0.830000 nan 48 1.690000 0.890000 nan 390.857343 0.185 0.216 -0.238 0.608 0.856 0.392 21.422303 14.977% 10.885475 12.194%
Keshavan MS 1996 2.110000 0.940000 nan 19 2.000000 1.110000 nan 191.028518 0.105 0.325 -0.532 0.741 0.322 0.747 9.485497 6.632% 6.639696 7.438%
Kumar A 1997 1.880000 0.980000 nan 28 0.870000 0.960000 nan 290.969870 1.027 0.283 0.472 1.582 3.628 0.000 12.478440 8.724% 7.979353 8.938%
Lenze EJ (A) 1999 0.730000 0.830000 nan 24 0.630000 0.660000 nan 240.749833 0.131 0.289 -0.435 0.698 0.454 0.650 11.971947 8.370% 7.769174 8.703%
Lloyd AJ 2004 3.200000 1.710000 nan 23 2.900000 1.750000 nan 201.728386 0.170 0.308 -0.434 0.775 0.552 0.581 10.511208 7.349% 7.126479 7.983%
Lloyd AJ 2004 3.600000 1.590000 nan 28 2.900000 1.750000 nan 201.656920 0.415 0.298 -0.169 1.000 1.393 0.164 11.238775 7.857% 7.453626 8.349%
Iosifescu DV 2005 0.610000 0.500000 nan 15 0.450000 0.560000 nan 180.533298 0.293 0.354 -0.401 0.986 0.827 0.409 7.980324 5.579% 5.865330 6.570%
Iosifescu DV 2005 0.540000 0.600000 nan 35 0.450000 0.560000 nan 180.587230 0.151 0.293 -0.424 0.726 0.515 0.607 11.634810 8.134% 7.625776 8.542%
Lin HF 2005 1.520000 0.800000 nan 37 0.880000 0.860000 nan 180.819724 0.770 0.297 0.187 1.352 2.589 0.010 11.314365 7.910% 7.486799 8.387%
Naish JH 2006 3.050000 4.230000 nan 21 2.720000 1.720000 nan 113.593707 0.090 0.372 -0.640 0.819 0.240 0.810 7.211318 5.042% 5.439036 6.093%
Naish JH 2006 4.300000 2.710000 nan 8 2.720000 1.720000 nan 112.182722 0.691 0.481 -0.252 1.635 1.436 0.151 4.314388 3.016% 3.610528 4.044%
Weber K 2009 0.700000 0.950000 nan 38 0.890000 1.130000 nan 621.065619 -0.177 0.206 -0.582 0.228 -0.857 0.391 23.469900 16.409% 11.390432 12.759%
Meta-analysis (fixed effect) 324 287 0.266 0.084 0.102 0.430 3.184 0.001 100%
Meta-analysis (random effects, DSL) 0.289 0.106 0.082 0.497 2.734 0.006 100%
σa: 0.212568 Q: 16.820672 dof: 11.0 P-value: 0.113

Forest plot

-2 -1 0 1 2 Greenwald BS 0.000000 Keshavan MS 1.000000 Kumar A 2.000000 Lenze EJ (A) 3.000000 Lloyd AJ 4.000000 Lloyd AJ 5.000000 Iosifescu DV 6.000000 Iosifescu DV 7.000000 Lin HF 8.000000 Naish JH 9.000000 Naish JH 10.000000 Weber K 11.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.50 -1.00 -1.50 -2.00 0.50 1.00 1.50 2.00 0.20 0.40 0.60 0.80

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.