Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Husain MM (B)199141443.81.24.91.4555.3MRI1.551763144
Lenze EJ (B)199924243.860.553.790.4853100.0MRI1.2510588417
Lacerda AL200325483.050.843.230.8441.216.029.4410.91000100MRI1.5514623065
Matsuo K200827263.580.623.80.5814.463.011.75000100MRI1.51.518439110
Pan CC2009170833.610.763.650.6369.465.9MRI1.5319235787
Pizzagalli DA200926315550697547273243.1757.729.3915.98000100MRI1.51.3319411368

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Husain MM (B) 1991 3.800000 1.200000 nan 41 4.900000 1.450000 nan 441.335374 -0.816 0.226 -1.260 -0.373 -3.606 0.000 19.520784 14.932% 8.473233 17.302%
Lenze EJ (B) 1999 3.860000 0.550000 nan 24 3.790000 0.480000 nan 240.516188 0.133 0.289 -0.433 0.700 0.462 0.644 11.970996 9.157% 6.652187 13.583%
Lacerda AL 2003 3.050000 0.840000 nan 25 3.230000 0.840000 nan 480.840000 -0.212 0.247 -0.697 0.273 -0.857 0.391 16.350883 12.507% 7.815551 15.959%
Matsuo K 2008 3.580000 0.620000 nan 27 3.800000 0.580000 nan 260.600725 -0.361 0.277 -0.904 0.182 -1.302 0.193 13.016533 9.957% 6.962982 14.218%
Pan CC 2009 3.610000 0.760000 nan 170 3.650000 0.630000 nan 830.720116 -0.055 0.134 -0.318 0.207 -0.414 0.679 55.751607 42.647% 11.802479 24.100%
Pizzagalli DA 2009 5550.000000 697.000000 nan 26 5472.000000 732.000000 nan 31716.302945 0.107 0.266 -0.414 0.629 0.404 0.687 14.118650 10.800% 7.266409 14.838%
Meta-analysis (fixed effect) 313 256 -0.184 0.087 -0.356 -0.013 -2.105 0.035 100%
Meta-analysis (random effects, DSL) -0.206 0.143 -0.486 0.074 -1.439 0.150 100%
σa: 0.258440 Q: 11.550642 dof: 5.0 P-value: 0.041

Forest plot

-2 -1 0 1 2 Husain MM (B) 0.000000 Lenze EJ (B) 1.000000 Lacerda AL 2.000000 Matsuo K 3.000000 Pan CC 4.000000 Pizzagalli DA 5.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.30 -0.60 -0.90 -1.20 0.30 0.60 0.90 1.20 0.08 0.16 0.24 0.32

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.