Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Parashos IA199872387.751.918.681.955.462.538.5MRI1.559870413
Lenze EJ (B)199924247.791.1292918137.71.04449030653100.0MRI1.2510588417
Lacerda AL200325485.381.5558920275.631.57482697541.216.029.4410.91000100MRI1.5514623065
Hickie IB (A)200745167.21.17.60.85266.736.126.864MRI1.51.516930719
Andreescu C200871321.110.181.240.2372.269.052.318.3171MRI1.51.518075490
Matsuo K200827267.181.1668847427.591.05315715814.463.011.75000100MRI1.51.518439110
Pan CC2009170837.241.4609859687.341.27148731869.465.9MRI1.5319235787
Pizzagalli DA20092631109141322.464517108411374.65028343.1757.729.3915.98000100MRI1.51.3319411368

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Parashos IA 1998 7.750000 1.910000 nan 72 8.680000 1.900000 nan 381.906580 -0.484 0.203 -0.883 -0.086 -2.383 0.017 24.206739 14.396% 16.484422 14.795%
Lenze EJ (B) 1999 7.790000 1.129292 nan 24 7.700000 1.044490 nan 241.087718 0.081 0.289 -0.485 0.647 0.282 0.778 11.989186 7.130% 9.731316 8.734%
Lacerda AL 2003 5.380000 1.555892 nan 25 5.630000 1.574827 nan 481.568452 -0.158 0.247 -0.642 0.326 -0.638 0.523 16.389843 9.747% 12.443086 11.168%
Hickie IB (A) 2007 7.200000 1.100000 nan 45 7.600000 0.800000 nan 161.032029 -0.383 0.293 -0.957 0.192 -1.305 0.192 11.627206 6.915% 9.491475 8.519%
Andreescu C 2008 1.110000 0.180000 nan 71 1.240000 0.230000 nan 320.196703 -0.656 0.218 -1.083 -0.229 -3.010 0.003 21.049778 12.518% 14.956858 13.424%
Matsuo K 2008 7.180000 1.166885 nan 27 7.590000 1.053157 nan 261.112589 -0.363 0.277 -0.906 0.180 -1.310 0.190 13.013719 7.739% 10.395604 9.330%
Pan CC 2009 7.240000 1.460986 nan 170 7.340000 1.271487 nan 831.401898 -0.071 0.134 -0.334 0.191 -0.531 0.595 55.739187 33.148% 26.814525 24.067%
Pizzagalli DA 2009 10914.000000 1322.464517 nan 26 10841.000000 1374.650283 nan 311351.179364 0.053 0.266 -0.468 0.575 0.200 0.841 14.135003 8.406% 11.098917 9.962%
Meta-analysis (fixed effect) 460 298 -0.235 0.077 -0.386 -0.084 -3.048 0.002 100%
Meta-analysis (random effects, DSL) -0.249 0.095 -0.434 -0.063 -2.623 0.009 100%
σa: 0.139113 Q: 9.672630 dof: 7.0 P-value: 0.208

Forest plot

-2 -1 0 1 2 Parashos IA 0.000000 Lenze EJ (B) 1.000000 Lacerda AL 2.000000 Hickie IB (A) 3.000000 Andreescu C 4.000000 Matsuo K 5.000000 Pan CC 6.000000 Pizzagalli DA 7.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.20 -0.40 -0.60 -0.80 0.20 0.40 0.60 0.80 0.08 0.16 0.24 0.32

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.