Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Keshavan MS199619190.630.90.260.56084.253.8MRI18723302
Kumar A199728291.290.750.920.6774.260.719.57MRI1.559169241
Greenwald BS2001hyperintensive40211.371.10.671.0274.672.558.326.35MRI1611559382
Greenwald BS2001normotensive41490.710.980.961.0474.770.726.44MRI1611559382
Lloyd AJ200451392.52.7322.717480.457MRI1115172942
Naish JH2006treatment responsive21110.561.6370.721.17157.1MRI1.5316894588
Naish JH2006treatment resistant8111.182.140.721.171150.0MRI1.5316894588
Weber K200938620.150.460.481.0266.1181.637.7647MRI30.920018381

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Keshavan MS 1996 0.630000 0.900000 nan 19 0.260000 0.560000 nan 190.749533 0.483 0.330 -0.163 1.129 1.466 0.143 9.200320 7.989% 4.924043 10.742%
Kumar A 1997 1.290000 0.750000 nan 28 0.920000 0.670000 nan 290.710399 0.514 0.270 -0.015 1.042 1.905 0.057 13.758238 11.947% 5.985264 13.057%
Greenwald BS 2001 1.370000 1.100000 nan 40 0.670000 1.020000 nan 211.073549 0.644 0.276 0.102 1.185 2.331 0.020 13.114740 11.388% 5.860175 12.784%
Greenwald BS 2001 0.710000 0.980000 nan 41 0.960000 1.040000 nan 491.013168 -0.245 0.212 -0.661 0.172 -1.151 0.250 22.150294 19.234% 7.166434 15.633%
Lloyd AJ 2004 2.500000 2.730000 nan 51 2.000000 2.710000 nan 392.721382 0.182 0.213 -0.236 0.600 0.855 0.393 22.006241 19.109% 7.151289 15.600%
Naish JH 2006 0.560000 1.637000 nan 21 0.720000 1.100000 nan 111.479813 -0.105 0.372 -0.835 0.625 -0.283 0.777 7.208450 6.260% 4.289648 9.358%
Naish JH 2006 1.180000 2.140000 nan 8 0.720000 1.100000 nan 111.611671 0.273 0.467 -0.643 1.189 0.583 0.560 4.579238 3.976% 3.197235 6.975%
Weber K 2009 0.150000 0.460000 nan 38 0.480000 1.020000 nan 620.852928 -0.384 0.208 -0.791 0.024 -1.847 0.065 23.141678 20.095% 7.267159 15.853%
Meta-analysis (fixed effect) 246 241 0.088 0.093 -0.095 0.271 0.946 0.344 100%
Meta-analysis (random effects, DSL) 0.140 0.148 -0.150 0.429 0.946 0.344 100%
σa: 0.307235 Q: 16.206877 dof: 7.0 P-value: 0.023

Forest plot

-2 -1 0 1 2 Keshavan MS 0.000000 Kumar A 1.000000 Greenwald BS 2.000000 Greenwald BS 3.000000 Lloyd AJ 4.000000 Naish JH 5.000000 Naish JH 6.000000 Weber K 7.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.20 -0.40 -0.60 -0.80 0.20 0.40 0.60 0.80 0.20 0.40 0.60 0.80

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.