Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Drevets WC199717210.000110.0000510.000180.0000743558.825.5MRI1.519126739
Botteron KN20023080.290.110.360.14160.015.2MRI1.5111958786
Brambilla P20021838300.282.329077094.4000100MRI1.51.512431853
Hastings RS2004males8863910581719338.90.023000100MRI1.51.514997169
Hastings RS2004females101063615671516038.9100.023000100MRI1.51.514997169
Coryell W2005101031511733313421.940.0MRI1.5116135631
Frodl T (A)200878780.570.240.520.2544.751.339.623.5121010MRI1.51.518406580

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Drevets WC 1997 0.000110 0.000051 nan 17 0.000180 0.000074 nan 210.000065 -1.058 0.351 -1.745 -0.371 -3.017 0.003 8.139007 10.381% 3.100823 14.903%
Botteron KN 2002 0.290000 0.110000 nan 30 0.360000 0.140000 nan 80.116440 -0.589 0.404 -1.381 0.204 -1.456 0.145 6.119261 7.805% 2.754454 13.239%
Brambilla P 2002 300.200000 82.300000 nan 18 290.000000 77.000000 nan 3878.707020 0.128 0.286 -0.434 0.689 0.446 0.655 12.190933 15.549% 3.550404 17.064%
Hastings RS 2004 639.000000 105.000000 nan 8 817.000000 193.000000 nan 8155.360870 -1.083 0.546 -2.154 -0.012 -1.982 0.047 3.348429 4.271% 2.006914 9.646%
Hastings RS 2004 636.000000 156.000000 nan 10 715.000000 160.000000 nan 10158.012658 -0.479 0.455 -1.371 0.413 -1.052 0.293 4.827692 6.157% 2.458402 11.816%
Coryell W 2005 315.000000 117.000000 nan 10 333.000000 134.000000 nan 10125.787519 -0.137 0.448 -1.015 0.741 -0.306 0.760 4.985423 6.359% 2.498659 12.009%
Frodl T (A) 2008 0.570000 0.240000 nan 78 0.520000 0.250000 nan 780.245051 0.203 0.161 -0.112 0.518 1.265 0.206 38.794896 49.480% 4.436429 21.323%
Meta-analysis (fixed effect) 171 173 -0.120 0.113 -0.341 0.101 -1.061 0.289 100%
Meta-analysis (random effects, DSL) -0.348 0.219 -0.778 0.082 -1.587 0.112 100%
σa: 0.446800 Q: 17.026519 dof: 6.0 P-value: 0.009

Forest plot

-2 -1 0 1 2 Drevets WC 0.000000 Botteron KN 1.000000 Brambilla P 2.000000 Hastings RS 3.000000 Hastings RS 4.000000 Coryell W 5.000000 Frodl T (A) 6.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.50 -1.00 -1.50 -2.00 0.50 1.00 1.50 2.00 0.20 0.40 0.60 0.80

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.