Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Botteron KN20023080.330.110.360.14160.015.2MRI1.5111958786
Brambilla P20021838295.462.1313.776.2094.4000100MRI1.51.512431853
Hastings RS2004males8872910482715038.90.023000100MRI1.51.514997169
Hastings RS2004females101068018876915838.9100.023000100MRI1.51.514997169
Coryell W200510103011583218721.940.0MRI1.5116135631
Frodl T (A)200878780.570.170.540.244.751.339.623.5121010MRI1.51.518406580

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Botteron KN 2002 0.330000 0.110000 nan 30 0.360000 0.140000 nan 80.116440 -0.252 0.399 -1.034 0.530 -0.632 0.527 6.278752 8.873% 6.196176 9.209%
Brambilla P 2002 295.400000 62.100000 nan 18 313.700000 76.200000 nan 3872.059293 -0.250 0.287 -0.813 0.312 -0.872 0.383 12.125092 17.135% 11.820871 17.569%
Hastings RS 2004 729.000000 104.000000 nan 8 827.000000 150.000000 nan 8129.065875 -0.718 0.521 -1.739 0.303 -1.378 0.168 3.685053 5.208% 3.656454 5.434%
Hastings RS 2004 680.000000 188.000000 nan 10 769.000000 158.000000 nan 10173.649071 -0.491 0.456 -1.384 0.402 -1.078 0.281 4.819237 6.811% 4.770440 7.090%
Coryell W 2005 301.000000 158.000000 nan 10 321.000000 87.000000 nan 10127.540190 -0.150 0.448 -1.028 0.728 -0.335 0.737 4.982505 7.041% 4.930364 7.328%
Frodl T (A) 2008 0.570000 0.170000 nan 78 0.540000 0.200000 nan 780.185607 0.161 0.160 -0.154 0.475 1.003 0.316 38.871041 54.932% 35.908414 53.369%
Meta-analysis (fixed effect) 154 152 -0.058 0.119 -0.291 0.175 -0.491 0.624 100%
Meta-analysis (random effects, DSL) -0.066 0.122 -0.305 0.173 -0.543 0.587 100%
σa: 0.046071 Q: 5.097431 dof: 5.0 P-value: 0.404

Forest plot

-2 -1 0 1 2 Botteron KN 0.000000 Brambilla P 1.000000 Hastings RS 2.000000 Hastings RS 3.000000 Coryell W 4.000000 Frodl T (A) 5.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.20 -0.40 -0.60 -0.80 0.20 0.40 0.60 0.80 0.20 0.40 0.60 0.80

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.