Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Botteron KN20023080.620.2087103260.720.265631323160.015.2MRI1.5111958786
Brambilla P20021838595.6137.1387181603.7145.3385014094.4000100MRI1.51.512431853
Bremner JD200215205882966342624333.3100MRI1.5311958777
Hastings RS2004males881368198.27506151644325.682360638.90.023000100MRI1.51.514997169
Hastings RS2004females10101316326.5039051484301.681951738.9100.023000100MRI1.51.514997169
Coryell W20051010616261.2098773654210.185156521.940.0MRI1.5116135631
Frodl T (A)200878781.140.3895895281.060.42720018744.751.339.623.5121010MRI1.51.518406580
Yucel K20086593462166.2511.5215.728.846.220.916.2529MRI11.218368034

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Botteron KN 2002 0.620000 0.208710 nan 30 0.720000 0.265631 nan 80.220930 -0.443 0.402 -1.230 0.344 -1.104 0.270 6.202857 5.303% 5.641361 6.779%
Brambilla P 2002 595.600000 137.138718 nan 18 603.700000 145.338501 nan 38142.807876 -0.056 0.286 -0.617 0.505 -0.195 0.845 12.209805 10.438% 10.209548 12.268%
Bremner JD 2002 588.000000 296.000000 nan 15 634.000000 262.000000 nan 20276.934518 -0.162 0.342 -0.833 0.508 -0.474 0.635 8.540387 7.301% 7.511069 9.025%
Hastings RS 2004 1368.000000 198.275061 nan 8 1644.000000 325.682361 nan 8269.612685 -0.968 0.537 -2.021 0.086 -1.801 0.072 3.462165 2.960% 3.279949 3.941%
Hastings RS 2004 1316.000000 326.503905 nan 10 1484.000000 301.681952 nan 10314.338035 -0.512 0.456 -1.406 0.382 -1.122 0.262 4.804058 4.107% 4.460233 5.359%
Coryell W 2005 616.000000 261.209877 nan 10 654.000000 210.185157 nan 10237.074250 -0.154 0.448 -1.032 0.725 -0.343 0.732 4.981724 4.259% 4.612975 5.543%
Frodl T (A) 2008 1.140000 0.389590 nan 78 1.060000 0.427200 nan 780.408828 0.195 0.161 -0.120 0.509 1.213 0.225 38.811275 33.179% 23.916664 28.738%
Yucel K 2008 462.000000 166.200000 nan 65 511.500000 215.700000 nan 93196.903485 -0.250 0.162 -0.568 0.068 -1.542 0.123 37.964436 32.455% 23.592371 28.348%
Meta-analysis (fixed effect) 234 265 -0.114 0.092 -0.295 0.067 -1.233 0.218 100%
Meta-analysis (random effects, DSL) -0.141 0.110 -0.355 0.074 -1.283 0.200 100%
σa: 0.126673 Q: 8.428742 dof: 7.0 P-value: 0.296

Forest plot

-2 -1 0 1 2 Botteron KN 0.000000 Brambilla P 1.000000 Bremner JD 2.000000 Hastings RS 3.000000 Hastings RS 4.000000 Coryell W 5.000000 Frodl T (A) 6.000000 Yucel K 7.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.30 -0.60 -0.90 -1.20 0.30 0.60 0.90 1.20 0.20 0.40 0.60 0.80

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.