Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Pantel J1997191346.556.343.374.472.478.964.226.7MRI1.51.259089060
Bremner JD200016161820742601947527074337.5100000MRI1.5310618023
McIntosh AM200192976679499682580729743.5655.6MRI11.8811200955
Caetano SC2004313178.679.4576.428.3639.277.427.911.8000100MRI1.51.515598548
Vythilingam M200438331626916691709224854160.5039MRI1.51.515231442

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Pantel J 1997 46.550000 6.300000 nan 19 43.370000 4.400000 nan 135.617651 0.552 0.367 -0.168 1.272 1.502 0.133 7.408490 13.626% 3.448568 17.728%
Bremner JD 2000 18207.000000 4260.000000 nan 16 19475.000000 2707.000000 nan 163568.994887 -0.346 0.357 -1.045 0.353 -0.971 0.331 7.865517 14.466% 3.544435 18.220%
McIntosh AM 2001 76679.000000 4996.000000 nan 9 82580.000000 7297.000000 nan 296852.765014 -0.843 0.395 -1.617 -0.069 -2.134 0.033 6.409133 11.788% 3.215201 16.528%
Caetano SC 2004 78.670000 9.450000 nan 31 76.420000 8.360000 nan 318.921662 0.249 0.255 -0.251 0.749 0.976 0.329 15.372744 28.274% 4.544517 23.361%
Vythilingam M 2004 16269.000000 1669.000000 nan 38 17092.000000 2485.000000 nan 332087.481518 -0.390 0.240 -0.861 0.081 -1.623 0.105 17.315234 31.846% 4.700401 24.163%
Meta-analysis (fixed effect) 113 122 -0.128 0.136 -0.394 0.138 -0.944 0.345 100%
Meta-analysis (random effects, DSL) -0.141 0.227 -0.585 0.304 -0.620 0.535 100%
σa: 0.393694 Q: 10.448975 dof: 4.0 P-value: 0.034

Forest plot

-2 -1 0 1 2 Pantel J 0.000000 Bremner JD 1.000000 McIntosh AM 2.000000 Caetano SC 3.000000 Vythilingam M 4.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.30 -0.60 -0.90 -1.20 0.30 0.60 0.90 1.20 0.10 0.20 0.30 0.40

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.