Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Pantel J1997191393.0912.6480551990.7610.7492325372.478.964.226.7MRI1.51.259089060
Bremner JD20001616361387997.450844377024276.9976854337.5100000MRI1.5310618023
Kumar A (A)20005130176.5529.65202.535.174.370.619.8MRI1.5510693154
McIntosh AM20019291500549957.70171316193213070.6785843.5655.6MRI11.8811200955
Caetano SC20043131150.0616.83363894146.3216.6228565539.277.427.911.8000100MRI1.51.515598548
Vythilingam M200438331583214921687620314160.5039MRI1.51.515231442

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Pantel J 1997 93.090000 12.648055 nan 19 90.760000 10.749233 nan 1311.924864 0.190 0.361 -0.517 0.898 0.528 0.598 7.680429 10.710% 3.480973 14.517%
Bremner JD 2000 36138.000000 7997.450844 nan 16 37702.000000 4276.997685 nan 166412.952877 -0.238 0.355 -0.933 0.458 -0.670 0.503 7.936062 11.066% 3.532546 14.732%
Kumar A (A) 2000 176.550000 29.650000 nan 51 202.500000 35.100000 nan 3031.759463 -0.809 0.239 -1.278 -0.341 -3.384 0.001 17.485309 24.382% 4.667101 19.463%
McIntosh AM 2001 150054.000000 9957.701713 nan 9 161932.000000 13070.678580 nan 2912446.374379 -0.934 0.398 -1.714 -0.154 -2.347 0.019 6.312788 8.803% 3.169738 13.219%
Caetano SC 2004 150.060000 16.833639 nan 31 146.320000 16.622857 nan 3116.728580 0.221 0.255 -0.279 0.720 0.866 0.386 15.399817 21.474% 4.504286 18.784%
Vythilingam M 2004 15832.000000 1492.000000 nan 38 16876.000000 2031.000000 nan 331762.586703 -0.586 0.243 -1.063 -0.109 -2.408 0.016 16.898209 23.564% 4.624218 19.285%
Meta-analysis (fixed effect) 164 152 -0.376 0.118 -0.608 -0.145 -3.185 0.001 100%
Meta-analysis (random effects, DSL) -0.360 0.204 -0.760 0.040 -1.762 0.078 100%
σa: 0.396327 Q: 14.095245 dof: 5.0 P-value: 0.015

Forest plot

-2 -1 0 1 2 Pantel J 0.000000 Bremner JD 1.000000 Kumar A (A) 2.000000 McIntosh AM 3.000000 Caetano SC 4.000000 Vythilingam M 5.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.30 -0.60 -0.90 -1.20 0.30 0.60 0.90 1.20 0.10 0.20 0.30 0.40

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.