Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Krishnan KR199325205.741.886.391.4274.168.0MRI1.558399409
Lisanby SH1993212112.072.6112.873.166542.9MRI1.558294897
Dupont RM (A)199530261570.77345.891716.85293.0238.670.012.5403057MRI1.557654126
Parashos IA1998723811.392.2611.632.7755.462.538.5MRI1.559870413
Caetano SC200117397.261.736.841.6842.894.1000100MRI1.51.511756014
Andreescu C200871320.880.1510.272.269.052.318.3171MRI1.51.518075490
McIntosh AM2001929114841566.083331125411168.79852843.5655.6MRI11.8811200955

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Krishnan KR 1993 5.740000 1.880000 nan 25 6.390000 1.420000 nan 201.692234 -0.377 0.303 -0.971 0.216 -1.246 0.213 10.901067 11.036% 7.084623 12.691%
Lisanby SH 1993 12.070000 2.610000 nan 21 12.870000 3.160000 nan 212.898077 -0.271 0.310 -0.879 0.337 -0.873 0.383 10.394823 10.523% 6.867266 12.302%
Dupont RM (A) 1995 1570.770000 345.890000 nan 30 1716.850000 293.020000 nan 26322.492460 -0.447 0.271 -0.979 0.085 -1.645 0.100 13.566514 13.734% 8.121660 14.549%
Parashos IA 1998 11.390000 2.260000 nan 72 11.630000 2.770000 nan 382.446723 -0.097 0.201 -0.491 0.296 -0.486 0.627 24.845085 25.152% 11.152494 19.979%
Caetano SC 2001 7.260000 1.730000 nan 17 6.840000 1.680000 nan 391.694969 0.244 0.292 -0.327 0.816 0.838 0.402 11.759459 11.905% 7.437457 13.324%
Andreescu C 2008 0.880000 0.150000 nan 71 1.000000 0.200000 nan 320.166947 -0.713 0.219 -1.142 -0.284 -3.260 0.001 20.875239 21.133% 10.275351 18.407%
McIntosh AM 2001 11484.000000 1566.083331 nan 9 12541.000000 1168.798528 nan 291267.888183 -0.816 0.394 -1.589 -0.044 -2.071 0.038 6.436127 6.516% 4.883061 8.748%
Meta-analysis (fixed effect) 245 205 -0.331 0.101 -0.528 -0.134 -3.288 0.001 100%
Meta-analysis (random effects, DSL) -0.336 0.134 -0.598 -0.073 -2.509 0.012 100%
σa: 0.222299 Q: 10.058985 dof: 6.0 P-value: 0.122

Forest plot

-2 -1 0 1 2 Krishnan KR 0.000000 Lisanby SH 1.000000 Dupont RM (A) 2.000000 Parashos IA 3.000000 Caetano SC 4.000000 Andreescu C 5.000000 McIntosh AM 6.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.30 -0.60 -0.90 -1.20 0.30 0.60 0.90 1.20 0.10 0.20 0.30 0.40

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.