Brede meta-analysis


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Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

First AuthorYearSubgroupNumber of PatientsNumber of ControlsPatient MeanPatient SDControl MeanControl SDPatient Age% Female PatientsAge of OnsetHam-D rating scaleAntidepressants %Mood stabilizers %Antipsychotics %Drug Free %ImagingMRI Field Strength (T)Slice Thickness (mm)PMID
Pantel J199719131193.11121193.512972.478.964.226.7MRI1.51.259089060
Kumar A199835301138.2160.631182.65137.9874.5771.471.2619.74MRI1.559636205
Caetano SC200431311412.78109.411417.89126.3439.277.427.911.8000100MRI1.51.515598548
Janssen J200428411372.8389.911330.7105.3664.04100.033.0461251421MRI1.51.215576058
Lloyd AJ200451391373.298.71381.4118.87480.457MRI1115172942
Frodl T200634341246.7861223.5114.445.544.138.824.891129MRI1.516951734
MacMaster FP2006males15151337.99115.441208.07104.2414.490.012.5213.77MRI1.51.516876142
MacMaster FP2006females20201117.1494.271103.1697.5114.49100.011.9713.77MRI1.51.516876142
Saylam C200624241524786117958152564711501033.475.024.4000100MRI1.5216395541
Weniger G200621231461110140611934100.028231000MRI1.51.316740316
Velakoulis D200612871401520114428144978914303922.641.721.5MRI1.51.516461856
Colla M200724141057.596.11096.7113.554.562.525.3000MRI1.51.0517023001
Hickie IB (A)200745161272.3111.61325.4118.55266.736.126.864MRI1.51.516930719
Maller JJ2007males22131.5640.08331.4880.13537.290.0MRI1.50.9417604352
Maller JJ2007females23171.390.09551.4460.112737.47100.0MRI1.50.9417604352
Tae WS200821201393.6170.841397123.5241.7100.033.2100000MRI1.51.318414838
Eker C200834391438.81551494.6137.331.776.52925.4000100MRI1.5218573301
Elderkin-Thompson V (A)2008early onset1820.51285.32146.931311.71152.9667.4483.326.7817.7800MRI1.51.418669941
Elderkin-Thompson V (A)2008late onset2520.51294.07125.991311.71152.967372.066.5418.1200MRI1.51.418669941
Lorenzetti V2009depressed3116.51477353.4138105.30851492735.8143141.433532.5271.0MRI1.5119239986
Lorenzetti V2009remitted3116.51469842.6150256.46471492735.8143141.433535.0758.1MRI1.5119239986
Pizzagalli DA200926311520071150388156242119157443.1757.729.3915.98000100MRI1.51.3319411368
Meisenzahl EM2009921381251.2105.881295.4141.9844.651.123.5147MRI1.51.519488671
Sun J200945301475390.81125172.951464585.54122448.9340.7851.126.168218MRI1.51.519486330
Weber K200938621525.6162.881578.48148.3366.1181.637.7647MRI30.920018381

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Pantel J 1997 1193.100000 112.000000 nan 19 1193.500000 129.000000 nan 13119.091561 -0.003 0.360 -0.709 0.702 -0.009 0.993 7.718739 2.137% 5.921936 2.736%
Kumar A 1998 1138.200000 160.630000 nan 35 1182.650000 137.980000 nan 30150.627462 -0.292 0.250 -0.782 0.199 -1.165 0.244 15.974208 4.423% 9.812603 4.534%
Caetano SC 2004 1412.780000 109.410000 nan 31 1417.890000 126.340000 nan 31118.178559 -0.043 0.254 -0.541 0.455 -0.168 0.867 15.496229 4.291% 9.630138 4.450%
Janssen J 2004 1372.830000 89.910000 nan 28 1330.700000 105.360000 nan 4199.423112 0.419 0.248 -0.067 0.905 1.690 0.091 16.272427 4.506% 9.924328 4.586%
Lloyd AJ 2004 1373.200000 98.700000 nan 51 1381.400000 118.800000 nan 39107.840118 -0.075 0.213 -0.492 0.342 -0.354 0.723 22.083884 6.115% 11.821627 5.462%
Frodl T 2006 1246.700000 86.000000 nan 34 1223.500000 114.400000 nan 34101.201186 0.227 0.243 -0.250 0.704 0.931 0.352 16.884928 4.675% 10.148858 4.689%
MacMaster FP 2006 1337.990000 115.440000 nan 15 1208.070000 104.240000 nan 15109.982660 1.149 0.398 0.369 1.930 2.885 0.004 6.302038 1.745% 5.050820 2.334%
MacMaster FP 2006 1117.140000 94.270000 nan 20 1103.160000 97.510000 nan 2095.903683 0.143 0.317 -0.478 0.764 0.451 0.652 9.971775 2.761% 7.163740 3.310%
Saylam C 2006 1524786.000000 117958.000000 nan 24 1525647.000000 115010.000000 nan 24116493.325697 -0.007 0.289 -0.573 0.559 -0.025 0.980 11.999914 3.323% 8.153762 3.767%
Weniger G 2006 1461.000000 110.000000 nan 21 1406.000000 119.000000 nan 23114.802315 0.470 0.306 -0.130 1.071 1.536 0.125 10.654162 2.950% 7.509262 3.470%
Velakoulis D 2006 1401520.000000 114428.000000 nan 12 1449789.000000 143039.000000 nan 87140088.514501 -0.342 0.309 -0.947 0.264 -1.107 0.268 10.477524 2.901% 7.421082 3.429%
Colla M 2007 1057.500000 96.100000 nan 24 1096.700000 113.500000 nan 14102.723886 -0.374 0.339 -1.039 0.291 -1.101 0.271 8.684761 2.405% 6.474459 2.992%
Hickie IB (A) 2007 1272.300000 111.600000 nan 45 1325.400000 118.500000 nan 16113.394047 -0.462 0.294 -1.039 0.114 -1.571 0.116 11.548010 3.197% 7.942569 3.670%
Maller JJ 2007 1.564000 0.083300 nan 22 1.488000 0.135000 nan 130.105085 0.707 0.361 -0.001 1.414 1.957 0.050 7.667749 2.123% 5.891876 2.722%
Maller JJ 2007 1.390000 0.095500 nan 23 1.446000 0.112700 nan 170.103092 -0.532 0.326 -1.171 0.106 -1.633 0.102 9.413343 2.606% 6.870915 3.175%
Tae WS 2008 1393.600000 170.840000 nan 21 1397.000000 123.520000 nan 20149.667386 -0.022 0.312 -0.635 0.590 -0.071 0.943 10.243200 2.836% 7.302757 3.374%
Eker C 2008 1438.800000 155.000000 nan 34 1494.600000 137.300000 nan 39145.794280 -0.379 0.237 -0.843 0.086 -1.599 0.110 17.828180 4.936% 10.482201 4.843%
Elderkin-Thompson V (A) 2008 1285.320000 146.930000 nan 18 1311.710000 152.960000 nan 20150.181632 -0.172 0.324 -0.806 0.462 -0.532 0.595 9.545220 2.643% 6.940911 3.207%
Elderkin-Thompson V (A) 2008 1294.070000 125.990000 nan 25 1311.710000 152.960000 nan 20138.729902 -0.125 0.298 -0.710 0.460 -0.419 0.675 11.239957 3.112% 7.795620 3.602%
Lorenzetti V 2009 1477353.400000 138105.308500 nan 31 1492735.800000 143141.433500 nan 16139841.281446 -0.108 0.305 -0.706 0.490 -0.355 0.723 10.752868 2.977% 7.558163 3.492%
Lorenzetti V 2009 1469842.600000 150256.464700 nan 31 1492735.800000 143141.433500 nan 16147871.115568 -0.152 0.305 -0.750 0.446 -0.499 0.618 10.737655 2.973% 7.550643 3.489%
Pizzagalli DA 2009 1520071.000000 150388.000000 nan 26 1562421.000000 191574.000000 nan 31174065.384156 -0.240 0.267 -0.763 0.283 -0.899 0.369 14.032678 3.885% 9.043957 4.179%
Meisenzahl EM 2009 1251.200000 105.880000 nan 92 1295.400000 141.980000 nan 138128.790803 -0.342 0.136 -0.608 -0.076 -2.523 0.012 54.422547 15.069% 17.335957 8.010%
Sun J 2009 1475390.810000 125172.950000 nan 45 1464585.540000 122448.930000 nan 30124097.963921 0.086 0.236 -0.376 0.548 0.365 0.715 17.983087 4.979% 10.535560 4.868%
Weber K 2009 1525.600000 162.880000 nan 38 1578.480000 148.330000 nan 62153.984998 -0.341 0.207 -0.747 0.066 -1.642 0.101 23.229194 6.432% 12.142094 5.610%
Meta-analysis (fixed effect) 765 811 -0.099 0.053 -0.202 0.004 -1.879 0.060 100%
Meta-analysis (random effects, DSL) -0.070 0.068 -0.203 0.063 -1.029 0.303 100%
σa: 0.198265 Q: 37.397203 dof: 24.0 P-value: 0.040

Forest plot

-2 -1 0 1 2 Pantel J 0.000000 Kumar A 1.000000 Caetano SC 2.000000 Janssen J 3.000000 Lloyd AJ 4.000000 Frodl T 5.000000 MacMaster FP 6.000000 MacMaster FP 7.000000 Saylam C 8.000000 Weniger G 9.000000 Velakoulis D 10.000000 Colla M 11.000000 Hickie IB (A) 12.000000 Maller JJ 13.000000 Maller JJ 14.000000 Tae WS 15.000000 Eker C 16.000000 Elderkin-Thompson V (A) 17.000000 Elderkin-Thompson V (A) 18.000000 Lorenzetti V 19.000000 Lorenzetti V 20.000000 Pizzagalli DA 21.000000 Meisenzahl EM 22.000000 Sun J 23.000000 Weber K 24.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.50 -1.00 -1.50 -2.00 0.50 1.00 1.50 2.00 0.10 0.20 0.30 0.40

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.