Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

AuthorYearStudyRegionPatient meanPatient SDNumber of patientsControls meanControls SDNumber of controlsPatient Y-BOCS meanPatient Y-BOCS SDControls Y-BOCS-meanControls Y-BOCS SDPatient mean agePatient SD ageControls mean ageControls SD ageTitle
Gilbert2000Intracranial1179.95115.42211129.61122.92128.195.9912.352.9312.472.6410807485Decrease in thalamic volumes of pediatric patients with obsessive-compulsive disorder who are taking paroxetine
Kim2001Intracranial1410.8131.8251357.5106.32524.2827.47276.211581113Grey matter abnormalities in obsessive-compulsive disorder: statistical parametric mapping of segmented magnetic resonance images
Kwon2003Intracranial1420134221354982226.77.226.26.112810792Similarity and disparity of obsessive-compulsive disorder and schizophrenia in MR volumetric abnormalities of the hippocampus-amygdala complex
Pujol2004Intracranial14071677214121457226.77.129.810.530.110.215237084Mapping structural brain alterations in obsessive-compulsive disorder
Ha2005Intracranial1420.6123.1501396.6129.72623.96.926.7724.14.815893428Fractal dimension of cerebral cortical surface in schizophrenia and obsessive-compulsive disorder
Yoo2008Intracranial1825.28201.98711818.57201.097122.848.426.67.726.686.0918303194Voxel-based morphometry study of gray matter abnormalities in obsessive-compulsive disorder

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Gilbert 2000 1179.950000 115.420000 nan 21 1129.610000 122.900000 nan 21119.218678 0.414 0.312 -0.198 1.026 1.327 0.185 10.257165 8.441% 10.109885 8.630%
Kim 2001 1410.800000 131.800000 nan 25 1357.500000 106.300000 nan 25119.730802 0.438 0.287 -0.123 1.000 1.529 0.126 12.182614 10.025% 11.975408 10.222%
Kwon 2003 1420.000000 134.000000 nan 22 1354.000000 98.000000 nan 22117.388245 0.552 0.308 -0.051 1.155 1.794 0.073 10.558093 8.688% 10.402110 8.879%
Pujol 2004 1407.000000 167.000000 nan 72 1412.000000 145.000000 nan 72156.387340 -0.032 0.167 -0.358 0.295 -0.191 0.849 35.995321 29.621% 34.244628 29.230%
Ha 2005 1420.600000 123.100000 nan 50 1396.600000 129.700000 nan 26125.368599 0.189 0.242 -0.285 0.664 0.782 0.434 17.032677 14.016% 16.630371 14.195%
Yoo 2008 1825.280000 201.980000 nan 71 1818.570000 201.090000 nan 71201.535491 0.033 0.168 -0.296 0.362 0.197 0.844 35.494995 29.209% 33.791480 28.844%
Meta-analysis (fixed effect) 261 237 0.154 0.091 -0.024 0.331 1.694 0.090 100%
Meta-analysis (random effects, DSL) 0.157 0.092 -0.024 0.338 1.696 0.090 100%
σa: 0.037687 Q: 5.135067 dof: 5.0 P-value: 0.400

Forest plot

-2 -1 0 1 2 Gilbert 0.000000 Kim 1.000000 Kwon 2.000000 Pujol 3.000000 Ha 4.000000 Yoo 5.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.20 -0.40 -0.60 -0.80 0.20 0.40 0.60 0.80 0.10 0.20 0.30 0.40

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.