Brede meta-analysis


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Input

Brede Wiki CSV title: 


Column names Number Mean SD Events
Experimentals:
Controls:

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Original data

AuthorYearStudyPatients mean changePatients SDPatients NControls mean changeControls SDControls NTitle
Degreef1991-1.052.0513-0.081.178Follow up MRI study in first episode schizophrenia
DeLisi19970.310.41500.130.3820Schizophrenia as a chronic active brain process: A study of progressive brain structural change subsequent to the onset of schizophrenia
Nair19972.181.65180.760.565Progression of cerebroventricular enlargement and the subtyping of schizophrenia
Rapoport19973.323.2916-0.210.1624Progressive ventricular change during adolescence
Mathalon20011.62.47240.721.3225Progressive brain volume changes and the clinical course of schizophrenia in men: A longitudinal magnetic resonance imaging study
Puri20010.592.03240.040.5512A serial longitudinal quantitative MRI study of cerebral changes in first-episode schizophrenia using image segmentation and subvoxel registration
James20020.631.54160.221.0216Evidence for non-progressive changes in adolescent-onset schizophrenia: Follow-up magnetic resonance imaging study
Ho20030.782.43730.31.1323Progressive structural brain abnormalities and their relationship to clinical outcome: A longitudinal magnetic resonance imaging study early in schizophrenia
Lieberman2005Olanzapine0.373.56420.341.7244Antipsychotic drug effects on brain morphology in first-episode psychosis
Lieberman2005Haloperidol0.373.17310.341.7244Antipsychotic drug effects on brain morphology in first-episode psychosis
Whitworth2005First-episode0.290.57210.140.1620Longitudinal volumetric MRI study in first- And multiple-episode male schizophrenia patients
Whitworth2005Multiple episodes0.160.38170.140.1620Longitudinal volumetric MRI study in first- And multiple-episode male schizophrenia patients
van Haren20081.672.88961.021.8113Progressive brain volume loss in schizophrenia over the course of the illness: Evidence of maturational abnormalities in early adulthood

Interpreted data and analysis

Study Experimentals Controls Effects
Mean SD Events N Mean SD Events NSDpooled Effect SE CI Z P Weight WeightDSL
Degreef 1991 -1.050000 2.050000 nan 13 -0.080000 1.170000 nan 81.777229 -0.524 0.458 -1.422 0.374 -1.143 0.253 4.762602 2.577% 3.663041 4.247%
DeLisi 1997 0.310000 0.410000 nan 50 0.130000 0.380000 nan 200.401843 0.443 0.267 -0.081 0.967 1.657 0.098 13.988903 7.568% 7.434214 8.619%
Nair 1997 2.180000 1.650000 nan 18 0.760000 0.560000 nan 51.504547 0.910 0.527 -0.122 1.942 1.728 0.084 3.606666 1.951% 2.938650 3.407%
Rapoport 1997 3.320000 3.290000 nan 16 -0.210000 0.160000 nan 242.070789 1.671 0.378 0.930 2.412 4.420 0.000 6.999181 3.787% 4.856683 5.631%
Mathalon 2001 1.600000 2.470000 nan 24 0.720000 1.320000 nan 251.968574 0.440 0.290 -0.128 1.007 1.519 0.129 11.931256 6.455% 6.810066 7.895%
Puri 2001 0.590000 2.030000 nan 24 0.040000 0.550000 nan 121.698686 0.317 0.356 -0.381 1.014 0.890 0.374 7.901197 4.275% 5.274510 6.115%
James 2002 0.630000 1.540000 nan 16 0.220000 1.020000 nan 161.306139 0.306 0.356 -0.392 1.004 0.860 0.390 7.894631 4.271% 5.271583 6.112%
Ho 2003 0.780000 2.430000 nan 73 0.300000 1.130000 nan 232.195849 0.217 0.240 -0.253 0.687 0.905 0.366 17.411811 9.420% 8.301493 9.624%
Lieberman 2005 0.370000 3.560000 nan 42 0.340000 1.720000 nan 442.774949 0.011 0.216 -0.412 0.434 0.050 0.960 21.488049 11.625% 9.126963 10.581%
Lieberman 2005 0.370000 3.170000 nan 31 0.340000 1.720000 nan 442.423284 0.012 0.234 -0.447 0.472 0.052 0.958 18.186317 9.839% 8.473544 9.824%
Whitworth 2005 0.290000 0.570000 nan 21 0.140000 0.160000 nan 200.423187 0.348 0.315 -0.270 0.965 1.103 0.270 10.075656 5.451% 6.162299 7.144%
Whitworth 2005 0.160000 0.380000 nan 17 0.140000 0.160000 nan 200.282681 0.069 0.330 -0.578 0.716 0.210 0.834 9.183073 4.968% 5.816524 6.743%
van Haren 2008 1.670000 2.880000 nan 96 1.020000 1.800000 nan 1132.357891 0.275 0.139 0.001 0.548 1.969 0.049 51.413408 27.815% 12.124422 14.057%
Meta-analysis (fixed effect) 441 374 0.278 0.074 0.134 0.422 3.775 0.000 100%
Meta-analysis (random effects, DSL) 0.305 0.108 0.094 0.516 2.834 0.005 100%
σa: 0.251054 Q: 22.125289 dof: 12.0 P-value: 0.036

Forest plot

-2 -1 0 1 2 Degreef 0.000000 DeLisi 1.000000 Nair 2.000000 Rapoport 3.000000 Mathalon 4.000000 Puri 5.000000 James 6.000000 Ho 7.000000 Lieberman 8.000000 Lieberman 9.000000 Whitworth 10.000000 Whitworth 11.000000 van Haren 12.000000 Meta-analysis (fixed effect) Meta-analysis (random effects)

Funnel plot

Effect size Standard error -0.50 -1.00 -1.50 -2.00 0.50 1.00 1.50 2.00 0.20 0.40 0.60 0.80

Warning

Column not matched "number_of_experimental_events". Column not matched "number_of_control_events".

Meta-analysis

This webservice will download a specified page from the Brede Wiki. The page should contain a comma-separated values (CSV) file with information for a meta-analysis. Study effect sizes and meta-analytic effect sizes will be computed.

The CSV file should provide information about the two groups: "experimentals" and "controls". The information you need to supply depends on whether your data is categorical (binary) or continuous:

You will usually need to specify the column names used for the data, but an automated guess will be performed if columns are not specified.

Symbols

M: mean, SD: standard deviation of data, SDpooled: Pooled standard deviation of data, N: number of data (subjects, etc.), MD: mean difference, SMD: standardized mean difference, CI: 95% confidence interval.

Examples

Acknowledgment

Matthew Kempton. Lundbeck Foundation Center for Integrated Molecular Brain Imaging (CIMBI)
Finn Årup Nielsen, CIMBI, DTU Informatics.