Brent A. Vogt; Stuart Derbyshire; Anthony K. Jones. Pain processing in four regions of human cingulate cortex localized with
co-registered PET and MR imaging.
European Journal of Neuroscience 8(7):1461-73, 1996.
Neurosurgical and positron emission tomography (PET) human studies and animal electrophysiological studies show that part of the anterior cingulate cortex (ACC) is nociceptive. Since the contribution of the ACC to pain processing is poorly understood, this study employed PET and magnetic resonance (MR) image co-registration in grouped and individual cases to locate regions of altered relative regional cerebral blood flow (rCBF). Seven right-handed, neurologically intact males were subjects; each received neuropsychological and pain threshold testing. Subjects were scanned during infusion of H2[15O]: four randomized scans during innocuous heat stimulation to the back of the left hand and four scans during noxious but bearable heat to the same place. The averaged rCBF values during innocuous stimuli were subtracted from those during noxious stimuli and statistical parametric maps (SPMs) for the group were computed to identify regions of altered relative rCBF. Finally, single-subject PET images of elevated and reduced rCBF were co-registered with MR images and projected onto reconstructions of the medial surface of the hemisphere. The SPM analysis of the group showed one site with elevated rCBF in the midcingulate cortex and one in the perigenual cortex predominantly contralateral to the side of stimulation. There were bilateral sites of reduced rCBF in the cingulofrontal transitional cortex and in the posterior cingulate cortex (PCC). Co-registered PET and MR images for individuals showed that only one case had a single, large region of elevated rCBF, while the others had a number of smaller regions. Six cases had at least one significant elevation of rCBF in the right hemisphere that primarily involved area 24b'; five of these cases also had an elevation in area 32', while the seventh case had elevated rCBF in these areas in the left hemisphere. The rostral site of elevated rCBF in the group was at the border of areas 24/24' and areas 32/32' although most cases had a site of elevation more rostral in the perigenual cingulate cortex. The ACC site of reduced rCBF was in areas 8 and 32 and that in the PCC included much of areas 29/30 in the callosal sulcus, areas 23b and 31 on the cingulate gyral surface and parietal area 7m. The localization of relative rCBF changes suggests different roles for the cingulate cortex in pain processing: (i) elevated rCBF in area 24' may be involved in response selection like nocifensive reflex inhibition; (ii) activation of the perigenual cortex may participate in affective responses to noxious stimuli like suffering associated with pain; and (iii) reduced rCBF in areas 8 and 32 may enhance pain perception in the perigenual cortex, while that in the PCC may disengage visually guided processes.Asymmetry: 0.49656 (left: -1, right: +1)
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+1: 1.00000 Brent A. Vogt; Stuart Derbyshire; Anthony K. Jones. Pain processing in four regions of human cingulate cortex localized with co-registered PET and MR imaging. European Journal of Neuroscience 8(7):1461-73, 1996. PMID: 8758953. WOBIB: 100.
+2: 0.58855 I. Tracey; L. Becerra; I. Chang; H. Breiter; L. Jenkins; D. Borsook; R. G. Gonzalez. Noxious hot and cold stimulation produce common patterns of brain activation in humans: a functional magnetic resonance imaging study. Neuroscience Letters 288(2):159-62, 2000. PMID: 10876085. WOBIB: 57.
+3: 0.58272 L. R. Becerra; H. C. Breiter; M. Stojanovic; S. Fishman; A. Edwards; A. R. Comite; R. G. Gonzalez; D. Borsook. Human brain activation under controlled thermal stimulation and habituation to noxious heat: an fMRI study. Magnetic Resonance in Medicine 41(5):1044-57, 1999. PMID: 10332889. WOBIB: 72.
+4: 0.57740 Alan G. Sanfey; James K. Rilling; Jessica A. Aronson; Leigh E. Nystrom; Jonathan D. Cohen. The Neural Basis of Economic decision-Making in the Ultimatum Game. Science 300(5626):1755-1758, 2003. PMID: 12805551. DOI: 10.1126/science.1082976. FMRIDCID: . WOBIB: 179.
+5: 0.56306 Ian Law; Claus Svarer; Sĝren Holm; Olaf B. Paulson. The activation pattern in normal humans during suppression, imagination and performance of saccadic eye movements. Acta Physiologica Scandinavica 161(3):419-434, 1997. PMID: 9401596. FMRIDCID: . WOBIB: 135.
+6: 0.56238 M. Tashiro; F. D. Juengling; M. J. Reinhardt; I. Brink; S. Hoegerle; M. Mix; K. Kubota; K. Yamaguchi; M. Itoh; H. Sasaki; E. Moser; E. U. Nitzsche. Reproducibility of PET brain mapping of cancer patients. Psychooncology 9(2):157-63, 2000. PMID: 10767753. WOBIB: 92.
+7: 0.56008 X. Xu; H. Fukuyama; S. Yazawa; T. Mima; T. Hanakawa; Y. Magata; M. Kanda; N. Fujiwara; K. Shindo; T. Nagamine; H. Shibasaki. Functional localization of pain perception in the human brain studied by PET. NeuroReport 8(2):555-559, 1997. PMID: 9080447. WOBIB: 13.
+8: 0.54963 L. J. Adler; F. E. Gyulai; D. J. Diehl; M. A. Mintun; P. M. Winter; L. L. Firestone. Regional brain activity changes associated with fentanyl analgesia elucidated by positron emission tomography. Anesthesia & Analgesia 84(1):120-126, 1997. PMID: 8989012. WOBIB: 101.
+9: 0.54834 Andreas Bartels; Semir Zeki. The neural basis of romantic love. NeuroReport 11(17):3829-3834, 2000. PMID: 11117499. WOBIB: 54.
+10: 0.53939 Arne May; Anish Bahra; Christian Büchel; Richard S. J. Frackowiak; Peter J. Goadsby. Hypothalamic activation in cluster headache attacks. Lancet 352(9124):275-278, 1998. PMID: 9690407. FMRIDCID: . WOBIB: 137.
+11: 0.53629 P. Petrovic; K. M. Petersson; P. H. Ghatan; S. Stone-Elander; M. Ingvar. Pain-related cerebral activation is altered by a distracting cognitive task. Pain 85(1-2):19-30, 2000. PMID: 10692599. WOBIB: 58.
+12: 0.53273 U. N. Frankenstein; W. Richter; M. C. McIntyre; F. Remy. Distraction modulates anterior cingulate gyrus activations during the cold pressor test. NeuroImage 14(4):827-36, 2001. PMID: 11554801. DOI: 10.1006/nimg.2001.0883. WOBIB: 83.
+13: 0.53250 Jonathan C. W. Brooks; Turo J. Nurmikko; William E. Bimson; Krish D. Singh; Neil Roberts. fMRI of thermal pain: effects of stimulus laterality and attention. NeuroImage 15(2):293-301, 2002. PMID: 11798266. DOI: 10.1006/nimg.2001.0974. WOBIB: 60.
+14: 0.52834 K. L. Casey; T. J. Morrow; J. Lorenz; S. Minoshima. Temporal and spatial dynamics of human forebrain activity during heat pain: analysis by positron emission tomography. Journal of Neurophysiology 85(2):951-9, 2001. PMID: 11160525. WOBIB: 95.
+15: 0.51360 Barbara Ravnkilde; Poul Videbech; Raben Rosenberg; Albert Gjedde; Anders Gade. Putative Tests of Frontal Lobe Function: A PET-Study of Brain Activation During Stroop's Test and Verbal Fluency. Journal of Clinical and Experimental Neuropsychology 24(4):534-547, 2002. PMID: 12187466. DOI: 10.1076/jcen.24.4.534.1033. FMRIDCID: . WOBIB: 176.
+16: 0.51132 P. E. Paulson; S. Minoshima; T. J. Morrow; K. L. Casey. Gender differences in pain perception and patterns of cerebral activation during noxious heat stimulation in humans. Pain 76(1-2):223-9, 1998. PMID: 9696477. WOBIB: 118.
+17: 0.51108 R. C. Coghill; J. D. Talbot; A. C. Evans; Ernst Meyer; Albert Gjedde; M. C. Bushnell; G. H. Duncan. Distributed processing of pain and vibration by the human brain. Journal of Neuroscience 14(7):4095-108, 1994. PMID: 8027764. WOBIB: 117.
+18: 0.50934 Greig I. de Zubicaray; Katie McMahon; Stephen J. Wilson; Santhi Muthiah. Brain activity during the encoding, retention, and retrieval of stimulus representations. Learning & Memory 8(5):243-251, 2001. PMID: 11584070. DOI: 10.1101/lm.40301. FMRIDCID: . WOBIB: 141.
+19: 0.50616 B. J. Casey; Jonathan D. Cohen; K. O'Craven; Richard J. Davidson; W. Irwin; C. A. Nelson; D. C. Noll; X. Hu; M. J. Lowe; B. R. Rosen; C. L. Truwitt; P. A. Turski. Reproducibility of fMRI results across four institutions using a spatial working memory task. NeuroImage 8(3):249-261, 1998. PMID: 9758739. FMRIDCID: . WOBIB: 116.
+20: 0.50455 Motoaki Sugiura; Ryuta Kawashima; Manabu Nakagawa; Ken Okada; Tachio Sato; Ryoi Goto; Kazunori Sato; Shuichi Ono; Torsten Schormann; Karl Zilles; Hiroshi Fukuda. Correlation between human personality and neural activity in cerebral cortex. NeuroImage 11(5 Pt 1):541-546, 2000. PMID: 10806039. DOI: 10.1006/nimg.2000.0564. FMRIDCID: . WOBIB: 149.
+21: 0.50280 Tim Shallice; Paul Fletcher; Chris D. Frith; Paul Grasby; Richard S. J. Frackowiak; Raymond J. Dolan. Brain regions associated with acquisition and retrieval of verbal episodic memory. Nature 368(6472):633-635, 1994. PMID: 8145849. DOI: 10.1038/368633a0. FMRIDCID: . WOBIB: 159.
+22: 0.49225 K. L. Casey; S. Minoshima; T. J. Morrow; R. A. Koeppe. Comparison of human cerebral activation pattern during cutaneous warmth, heat pain, and deep cold pain. Journal of Neurophysiology 76(1):571-81, 1996. PMID: 8836245. WOBIB: 102.
+23: 0.48815 L. M. Parsons; D. Osherson. New Evidence for Distinct Right and Left Brain Systems for Deductive versus Probabilistic Reasoning. Cerebral Cortex 11(10):954-65, 2001. PMID: 11549618. WOBIB: 47.
+24: 0.48776 Russell A. Poldrack; Anthony D. Wagner; Matthew W. Prull; John E. Desmond; Gary H. Glover; John D. E. Gabrieli. Functional Specialization for Sematic and Phonological Processing in the Left Inferior Prefrontal Cortex. NeuroImage 10(1):15-35, 1999. PMID: 10385578. DOI: 10.10061/nimg.1999.0441. FMRIDCID: . WOBIB: 178.
Silvina Horovitz; Pawel Skudlarski; John Gore. Correlations and dissociations between BOLD signal and P300 amplitude in
an auditory oddball task: a parametric approach to combining fMRI and ERP.
Magnetic Resonance Imaging 20(4):319, 2002.
-1: 0.00497 Semir Zeki; R. J. Perry; A. Bartels. The processing of kinetic contours in the brain. Cerebral Cortex 13(2):189-202, 2003. PMID: 12507950. WOBIB: 52.
-2: 0.00826 A. T. Smith; M. W. Greenlee; K. D. Singh; F. M. Kraemer; J. Hennig. The processing of first- and second-order motion in human visual cortex assessed by functional magnetic resonance imaging (fMRI). Journal of Neuroscience 18(10):3816-30, 1998. PMID: 9570811. WOBIB: 53.
-3: 0.01229 U. Hasson; T. Hendler; D. Ben Bashat; R. Malach. Vase or face? A neural correlate of shape-selective grouping processes in the human brain. Journal of Cognitive Neuroscience 13(6):744-53, 2001. PMID: 11564319. DOI: 10.1162/08989290152541412. FMRIDCID: 2-2001-111P8. WOBIB: 36.
-4: 0.01420 J. D. Bremner; R. B. Innis; S. M. Southwick; L. Staib; S. Zoghbi; D. S. Charney. Decreased benzodiazepine receptor binding in prefrontal cortex in combat-related posttraumatic stress disorder. American Journal of Psychiatry 157(7):1120-1126, 2000. PMID: 10873921. WOBIB: 67.
Semir Zeki; J. D. Watson; C. J. Lueck; Karl J. Friston; C. Kennard; Richard S. J. Frackowiak. A direct demonstration of functional specialization in human visual cortex.
Journal of Neuroscience 11(3):641-649, 1991.