WOEXP: 344 - Apolipoprotein E e4 allele
 
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Apolipoprotein E e4 allele. CBF in healthy people with apolipoprotein E e4/e4 allele genotype versus controls with e2/e3 or e3/e3 genotype. WOEXP: 344.

Eric M. Reiman; R. J. Caselli; L. S. Yun; K. Chen; D. Bandy; S. Minoshima; S. N. Thibodeau; D. Osborne. Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. New England Journal of Medicine 334(12):752-8, 1996. PMID: 8592548. WOBIB: 112.

Disease - Alzheimer's disease
WOEXT: 347.

Modality:PET/MRI
Measured variable: CMRGlu
Tracer: F-18 2-deoxy-2-fluro-D-glucose (FDG)
Scanner: Siemens, ECAT 951/31
Number of subjects: 33

Asymmetry: 0.00000 (left: -1, right: +1)

  x     y     z   Lobar anatomy Functional area WOROI Value
0 -32 32 Posterior cingulate      
43 -53 54 Right parietal      
-61 -41 38 Left parietal      
61 -28 -14 Right temporal      
-59 -30 -14 Left temporal      
41 38 41 Right prefrontal      
-43 20 47 Left prefrontal      

corner cube of volume 344 (Apolipoprotein E e4 allele)

[ PNG | VRML (90Kb) ]

Related - positive correlated volumes

+1: 1.00000 Apolipoprotein E e4 allele. CBF in healthy people with apolipoprotein E e4/e4 allele genotype versus controls with e2/e3 or e3/e3 genotype. WOEXP: 344.
Eric M. Reiman; R. J. Caselli; L. S. Yun; K. Chen; D. Bandy; S. Minoshima; S. N. Thibodeau; D. Osborne. Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. New England Journal of Medicine 334(12):752-8, 1996. PMID: 8592548. WOBIB: 112.

+2: 0.35772 Arabic numerical notation. Arabic notation versus verbal notation of numbers. WOEXP: 24.
P. Pinel; S. Dehaene; D. Riviere; D. LeBihan. Modulation of parietal activation by semantic distance in a number comparison task. NeuroImage 14(5):1013-26, 2001. PMID: 11697933. DOI: 10.1006/nimg.2001.0913. WOBIB: 10.

+3: 0.34530 Deactivations in romantic love. Viewing of colored pictures of three friends of the same sex as their loved partner versus viewing pictures of the faces of boy- or girlfriend (loved once). WOEXP: 177.
Andreas Bartels; Semir Zeki. The neural basis of romantic love. NeuroReport 11(17):3829-3834, 2000. PMID: 11117499. WOBIB: 54.

+4: 0.32481 Feign autobiographical memory impairment. Feigning memory impairment in autobiographical memory versus accurate recall. WOEXP: 125.
Tatia M. C. Lee; Ho-Ling Liu; Li-Hai Tan; Chetwyn C. H. Chan; Srikanth Mahankali; Ching-Mei Feng; Jinwen Hou; Peter T. Fox; Jia-Hong Gao. Lie detection by functional magnetic resonance imaging. Human Brain Mapping 15(3):157-64, 2002. PMID: 11835606. WOBIB: 37.

+5: 0.32464 Decline in Alzheimer's disease. Patients with Alzheimer's disease in 1-year follow-up during mental resting state versus early Alzheimer's disease. WOEXP: 292.
Gene E. Alexander; Kewei Chen; Pietro Pietrini; Stanley I. Rapoport; Eric M. Reiman. Longitudinal PET Evaluation of Cerebral Metabolic Decline in Dementia: A Potential Outcome Measure in Alzheimer's Disease Treatment Studies. American Journal of Psychiatry 159(5):738-45, 2002. PMID: 11986126. WOBIB: 91.

+6: 0.31858 Newly learned personal names versus names of famous people. Retrieval and whispering of newly learned personal names from presented photographs of faces and previously memorized association between face and name. WOEXP: 138.
Takashi Tsukiura; Toshikatsu Fujii; Reiko Fukatsu; Taisuke Otsuki; Jiro Okuda; Atsushi Umetsu; Kyoko Suzuki; Michio Tabuchi; Isao Yanagawa; Tatsuo Nagasaka; Ryuta Kawashima; Hiroshi Fukuda; Shoki Takahashi; Atsushi Yamadori. Neural basis of the retrieval of people's names: evidence from brain-damaged patients and fMRI. Journal of Cognitive Neuroscience 14(6):922-37, 2002. PMID: 12191459. DOI: 10.1162/089892902760191144. FMRIDCID: 2-2002-112QC. WOBIB: 41.

+7: 0.31077 Immediate pointing versus previous target pointing. Movement of a stylus with the right hand for the movement of a screen cursor from a central fixation point to an immediate target in the periphery versus movement to a target from the previous presentation. WOEXP: 576.
F. Lacquaniti; Daniela Perani; E. Guigon; V. Bettinardi; M. Carrozzo; F. Grassi; Yves Rossetti; F. Fazio. Visuomotor Transformations for Reaching to Memorized Targets: A PET study. NeuroImage 5(2):129-146, 1997. PMID: 9345543. DOI: 10.1006.nimg.1996.0254. FMRIDCID: . WOBIB: 182.

+8: 0.28732 Distance effect in number decision.. Distance effect when deciding which number is the largest. WOEXP: 25.
P. Pinel; S. Dehaene; D. Riviere; D. LeBihan. Modulation of parietal activation by semantic distance in a number comparison task. NeuroImage 14(5):1013-26, 2001. PMID: 11697933. DOI: 10.1006/nimg.2001.0913. WOBIB: 10.

+9: 0.28466 Visuospatial attention with cue effect to valid cues. Visuospatial attention with directional cue either by central expectancy where a central diamond indicated left/right cue or by a change in luminance in a peripheral square, and with cue effect to valid cue. WOEXP: 372.
M. M. Mesulam; A. C. Nobre; Y. H. Kim; T. B. Parrish; D. R. Gitelman. Heterogeneity of cingulate contributions to spatial attention. NeuroImage 13(6 Pt 1):1065-72, 2001. PMID: 11352612. DOI: 10.1006/nimg.2001.0768. WOBIB: 120.

+10: 0.28106 Other-attribution versus self-attribution. The subject moved a joystick, and a cursor on the screen was controlled by a computer. WOEXP: 74.
Chl÷Ú Farrer; Chris D. Frith. Experiencing oneself vs another person as being the cause of an action: the neural correlates of the experience of agency. NeuroImage 15(3):596-603, 2002. PMID: 11848702. DOI: 10.1006/nimg.2001.1009. WOBIB: 23.

+11: 0.27742 Nonautobiographical episodic memory retrieval. Listening to sentences that contained episodic information from an third-person autobiography versus eyes closed. WOEXP: 207.
G. R. Fink; H. J. Markowitsch; M. Reinkemeier; T. Bruckbauer; J. Kessler; W. D. Heiss. Cerebral representation of one's own past: neural networks involved in autobiographical memory. Journal of Neuroscience 16(13):4275-82, 1996. PMID: 8753888. WOBIB: 68.

+12: 0.27498 Deactivation in amusement film viewing versus neutral film viewing. Passive viewing of 2.5 minute emotional film clips. WOEXP: 280.
S. Aalto; P. Naatanen; E. Wallius; L. Metsahonkala; H. Stenman; P. M. Niem; H. Karlsson. Neuroanatomical substrata of amusement and sadness: a PET activation study using film stimuli. NeuroReport 13(1):67-73, 2002. PMID: 11924897. WOBIB: 88.

+13: 0.26941 Passive versus active, hypothesis generation group. Passive state with simulus versus active states in connection with visual information processing task: same-different discrimination, visual search, spatial attention, language, memory, cross-modal imagery. hypothesis generation group. WOEXP: 530.
Gordon L. Shulman; Julie A. Fiez; Maurizio Corbetta; Randy L. Buckner; Francis M. Miezin; Marcus E. Raichle; Steven E. Petersen. Common Blood Flow Changes across Visual Tasks: II. Decreases in Cerebral Cortex. Journal of Cognitive Neuroscience 9(5):648-663, 1997. FMRIDCID: . WOBIB: 173.

+14: 0.25632 Hot pain on left hand (group 2). 46 degrees hot pain to the dorsum of the left hand versus 35 degree stimuli. WOEXP: 227.
L. R. Becerra; H. C. Breiter; M. Stojanovic; S. Fishman; A. Edwards; A. R. Comite; R. G. Gonzalez; D. Borsook. Human brain activation under controlled thermal stimulation and habituation to noxious heat: an fMRI study. Magnetic Resonance in Medicine 41(5):1044-57, 1999. PMID: 10332889. WOBIB: 72.

+15: 0.25463 Attention to consonant-vowels in the right ear versus divided attention. Either attend to both ears or attend to right ear and press a button when the target stimulus appeared. WOEXP: 39.
K. Hugdahl; Ian Law; S. Kyllingsbaek; K. Bronnick; Anders Gade; Olaf B. Paulson. Effects of attention on dichotic listening: an 15O-PET study. Human Brain Mapping 10(2):87-97, 2000. PMID: 10864233. WOBIB: 14.

+16: 0.24850 Feign digit memory impairment. Feigning memory impairment in digit memory versus accurate recall. WOEXP: 124.
Tatia M. C. Lee; Ho-Ling Liu; Li-Hai Tan; Chetwyn C. H. Chan; Srikanth Mahankali; Ching-Mei Feng; Jinwen Hou; Peter T. Fox; Jia-Hong Gao. Lie detection by functional magnetic resonance imaging. Human Brain Mapping 15(3):157-64, 2002. PMID: 11835606. WOBIB: 37.

+17: 0.24771 Relative metabolic decreases in Alzheimer's disease. Relative metabolic differences between Alzheimer's disease patients and controls. WOEXP: 191.
Nora D. Volkow; Wei Zhu; Christoph A. Felder; Klaus Mueller; Tomihisa F. Welsh; Gene J. Wang; Mony J. de Leon. Changes in brain functional homogeneity in subjects with Alzheimer's disease. Psychiatry Research 114(1):39-50, 2002. PMID: 11864808. WOBIB: 61.

+18: 0.24729 Visuospatial attention with cue effect to invalid cues. Visuospatial attention with directional cue either by central expectancy where a central diamond indicated left/right cue or by a change in luminance in a peripheral square, and with cue effect to invalid cue. WOEXP: 373.
M. M. Mesulam; A. C. Nobre; Y. H. Kim; T. B. Parrish; D. R. Gitelman. Heterogeneity of cingulate contributions to spatial attention. NeuroImage 13(6 Pt 1):1065-72, 2001. PMID: 11352612. DOI: 10.1006/nimg.2001.0768. WOBIB: 120.

+19: 0.24698 Color matching. Color matching with colored random polygons presented serially in pairs on a screen with response by left or right mouse button press versus color matching. WOEXP: 254.
Claus Bundesen; Axel Larsen; Soren Kyllingsbaek; Olaf B. Paulson; Ian Law. Attentional effects in the visual pathways: a whole-brain PET study. Experimental Brain Research 147(3):394-406, 2002. PMID: 12428147. DOI: 10.1007/s00221-002-1243-1. WOBIB: 81.

+20: 0.24187 Visual artefact object. Decision or categorization of visual artefact. WOEXP: 4.
Christian Gerlach; I. Law; Anders Gade; O. B. Paulson. Categorization and category effects in normal object recognition: a PET study. Neuropsychologia 38(13):1693-703, 2000. PMID: 11099727. WOBIB: 2.

+21: 0.22899 Warmth on left hand versus heat. Warm thermal stimulus on dorsal surface of the left hand with and without a Stroop task versus heat pain. WOEXP: 313.
Brent A. Vogt; Stuart Derbyshire; Anthony K. Jones. Pain processing in four regions of human cingulate cortex localized with co-registered PET and MR imaging. European Journal of Neuroscience 8(7):1461-73, 1996. PMID: 8758953. WOBIB: 100.

+22: 0.22678 Visuospatial 2-back, Minnesota site. Viewing of dots in one of four displayed boxes with button pressing for indicating where the dot occured two trials back versus pressing buttons in zero-back. WOEXP: 354.
B. J. Casey; Jonathan D. Cohen; K. O'Craven; Richard J. Davidson; W. Irwin; C. A. Nelson; D. C. Noll; X. Hu; M. J. Lowe; B. R. Rosen; C. L. Truwitt; P. A. Turski. Reproducibility of fMRI results across four institutions using a spatial working memory task. NeuroImage 8(3):249-261, 1998. PMID: 9758739. FMRIDCID: . WOBIB: 116.

+23: 0.22148 Serotonin synthesis capacity, proportional scaling. Men versus women. Serotonin synthesis rate. WOEXP: 285.
H. Okazawa; M. Leyton; C. Benkelfat; S. Mzengeza; M. Diksic. Statistical mapping analysis of serotonin synthesis images generated in healthy volunteers using positron-emission tomography and alpha-[11C]methyl-L-tryptophan. Journal of Psychiatry Neuroscience 25(4):359-370, 2000. PMID: 11022401. WOBIB: 89.

+24: 0.22059 Rest versus practiced word recall. Resting versus speak load words recalled from a list of 15 words practiced one week before. WOEXP: 272.
Nancy C. Andreasen; D. S. O'Leary; T. Cizadlo; Stephan Arndt; K. Rezai; G. L. Watkins; L. L. Ponto; R. D. Hichwa. II. PET studies of memory: novel versus practiced free recall of word lists. NeuroImage 2(4):296-305, 1995. PMID: 9343614. WOBIB: 85.

+25: 0.21878 Newly learned occupation or names of people versus occupation or name of famous people. Retrieval and whispering of newly learned occupation and names of unfamilar people from presented photographs of faces and previously memorized association between face and name. Conjunction between occupation and names. WOEXP: 140.
Takashi Tsukiura; Toshikatsu Fujii; Reiko Fukatsu; Taisuke Otsuki; Jiro Okuda; Atsushi Umetsu; Kyoko Suzuki; Michio Tabuchi; Isao Yanagawa; Tatsuo Nagasaka; Ryuta Kawashima; Hiroshi Fukuda; Shoki Takahashi; Atsushi Yamadori. Neural basis of the retrieval of people's names: evidence from brain-damaged patients and fMRI. Journal of Cognitive Neuroscience 14(6):922-37, 2002. PMID: 12191459. DOI: 10.1162/089892902760191144. FMRIDCID: 2-2002-112QC. WOBIB: 41.


Antirelated - negatively correlated volumes

-1: -0.06942 Chronic facial pain versus no pain after thalamic stimulation. Chronic pain in the right side of the face versus no pain after thalamic stimulation in the left ventroposterior medial thalamic nucleus (-7, -20, +2). WOEXP: 193.
Ron C. Kupers; J. M. Gybels; Albert Gjedde. Positron emission tomography study of a chronic pain patient successfully treated with somatosensory thalamic stimulation. Pain 87(3):295-302, 2000. PMID: 10963909. WOBIB: 62.

-2: -0.06838 Happy versus neutral. Recalling of powerful and personal autobiographical emotional episodes invoking happiness versus recalling emotionally neutral life episodes. WOEXP: 484.
Mario Pelletier; Alain Bouthillier; Johanne Levesque; Serge Carrier; Claude Breault; Vincent Paquette; Boualem Mensour; Jean-Maxime Leroux; Gilles Beaudoin; Pierre Bourgouin; Mario Beauregard. Separate neural circuits for primary emotions? Brain activity during self-induced sadness and happiness in professional actors. NeuroReport 14(8):1111-1116, 2003. PMID: 12821792. DOI: 10.1097/01.wnr.0000075421.59944.69. FMRIDCID: . WOBIB: 157.

-3: -0.06749 Sad versus neutral. Recalling of powerful and personal autobiographical emotional episodes invoking sadness versus recalling emotionally neutral life episodes. WOEXP: 483.
Mario Pelletier; Alain Bouthillier; Johanne Levesque; Serge Carrier; Claude Breault; Vincent Paquette; Boualem Mensour; Jean-Maxime Leroux; Gilles Beaudoin; Pierre Bourgouin; Mario Beauregard. Separate neural circuits for primary emotions? Brain activity during self-induced sadness and happiness in professional actors. NeuroReport 14(8):1111-1116, 2003. PMID: 12821792. DOI: 10.1097/01.wnr.0000075421.59944.69. FMRIDCID: . WOBIB: 157.

-4: -0.06368 Disgust from recall. Disgust generated from recalling disgust autobiographical memories from scripts versus view neutral films and recalling neutral autobiographical memories. WOEXP: 548.
Richard D. Lane; Eric M. Reiman; Geoffrey L. Ahern; Gary E. Schwartz; Richard J. Davidson. Neuroanatomical Correlates of Happiness, Sadness, and Disgust. The American Journal of Psychiatry 154(7):926-933, 1997. PMID: 9210742. FMRIDCID: . WOBIB: 177.

-5: -0.06164 Dynamic complex visual scene. Passive viewing and hearing of a movie (James Bond, Tomorrow never dies) with changes from color to black and white every 30 seconds and interrupted every 2.5 or 3 minutes with a blank period. Areas with high loadings in an independent component analysis.. WOEXP: 174.
Semir Zeki; R. J. Perry; A. Bartels. The processing of kinetic contours in the brain. Cerebral Cortex 13(2):189-202, 2003. PMID: 12507950. WOBIB: 52.

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