| Using positron emission tomography (PET), we found contralateral
activity correlated with graded cooling stimuli only in the dorsal margin
of the middle/posterior insula in humans||A. D. Craig; K. Chen; D. Bandy; Eric M. Reiman. Thermosensory activation of insular cortex.
Nature Neuroscience 3(2):184-190, 2000.
| In particular, activity
within the posterior insula was contralateral to the site of stimulation,
tested using regions of interest (ROI) analysis: significant side x site
interaction (P = 0||Jonathan C. W. Brooks; Turo J. Nurmikko; William E. Bimson; Krish D. Singh; Neil Roberts. fMRI of thermal pain: effects of stimulus laterality and attention.
NeuroImage 15(2):293-301, 2002.
Significant rCBF increases to 50 degrees C stimuli were found
contralaterally in the thalamus, anterior cingulate cortex, premotor
cortex, and secondary somatosensory (S2) and posterior insular cortices||K. L. Casey; S. Minoshima; T. J. Morrow; R. A. Koeppe. Comparison of human cerebral activation pattern during cutaneous warmth,
heat pain, and deep cold pain.
Journal of Neurophysiology 76(1):571-81, 1996.
| Both genders showed a bilateral activation of premotor cortex
in addition to the activation of a number of contralateral structures,
including the posterior insula, anterior cingulate cortex and the
cerebellar vermis, during heat pain||P. E. Paulson; S. Minoshima; T. J. Morrow; K. L. Casey. Gender differences in pain perception and patterns of cerebral activation during noxious heat stimulation in humans.
Pain 76(1-2):223-9, 1998.