A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression

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A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression
Authors: Srijan Sen, Randolph M. Nesse, Scott F. Stoltenberg, Sheng Li, Lillian Gleiberman, Aravinda Chakravarti, Alan B. Weder, Margit Burmeister
Citation: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 28 (2): 397-391. 2003 February
Database(s): PubMed (PMID/12589394)
DOI: 10.1038/sj.npp.1300053.
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A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression reports a personality genetics study on the rs6265 (val66met) genetic polymorphims in the BDNF gene with personality traits assessed with NEO PI.

[edit] Subjects

Subject group #1 (help)
Caucasian Americans
Subjects/♂/♀: 268 / 173 /
Age: (25–40)
Nationality: American
Approval: define approval
Databases:

Group 1 of 268 caucasian Americans with 173 males were included in the study. The American group was from 25 up to 40 years old.

The subjects participated in the Family Blood Pressure Program.

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
BDNF met66val val/val NEO PI Neuroticism 86.35 20.28 255 Caucasian Americans 12589394
BDNF met66val met/val NEO PI Neuroticism 83.11 21.19 161 Caucasian Americans 12589394
BDNF met66val met/met NEO PI Neuroticism 73.90 16.37 20 Caucasian Americans 12589394
BDNF met66val val/val NEO PI Extraversion 107.22 17.09 255 Caucasian Americans 12589394
BDNF met66val met/val NEO PI Extraversion 108.17 17.82 162 Caucasian Americans 12589394
BDNF met66val met/met NEO PI Extraversion 111.18 12.34 20 Caucasian Americans 12589394
BDNF met66val val/val NEO PI Openness to experience 104.19 17.05 254 Caucasian Americans 12589394
BDNF met66val met/val NEO PI Openness to experience 101.90 15.56 160 Caucasian Americans 12589394
BDNF met66val met/met NEO PI Openness to experience 102.18 16.5 20 Caucasian Americans 12589394
BDNF met66val val/val NEO PI Conscientiousness 48.10 8.03 258 Caucasian Americans 12589394
BDNF met66val met/val NEO PI Conscientiousness 47.53 8.37 161 Caucasian Americans 12589394
BDNF met66val met/met NEO PI Conscientiousness 48.53 8.72 20 Caucasian Americans 12589394
BDNF met66val val/val NEO PI Agreeableness 47.19 6.44 259 Caucasian Americans 12589394
BDNF met66val met/val NEO PI Agreeableness 47.21 7 162 Caucasian Americans 12589394
BDNF met66val met/met NEO PI Agreeableness 48.05 8.68 20 Caucasian Americans 12589394
BDNF met66val val/val NEO PI Anxiety 15.83 4.98 258 Caucasian Americans 12589394
BDNF met66val met/val NEO PI Anxiety 14.94 4.82 161 Caucasian Americans 12589394
BDNF met66val met/met NEO PI Anxiety 13.52 4.56 20 Caucasian Americans 12589394
BDNF met66val val/val NEO PI Angry hostility 12.18 4.5 258 Caucasian Americans 12589394
BDNF met66val met/val NEO PI Angry hostility 11.98 4.69 161 Caucasian Americans 12589394
BDNF met66val met/met NEO PI Angry hostility 11.77 3.67 20 Caucasian Americans 12589394
BDNF met66val val/val NEO PI Depression 14.39 5.43 255 Caucasian Americans 12589394
BDNF met66val met/val NEO PI Depression 13.34 5.84 161 Caucasian Americans 12589394
BDNF met66val met/met NEO PI Depression 11.39 4.65 20 Caucasian Americans 12589394
BDNF met66val val/val NEO PI Impulsiveness 16.72 3.69 258 Caucasian Americans 12589394
BDNF met66val met/val NEO PI Impulsiveness 16.91 3.93 161 Caucasian Americans 12589394
BDNF met66val met/met NEO PI Impulsiveness 15.15 5.05 20 Caucasian Americans 12589394
BDNF met66val val/val NEO PI Vulnerability 11.41 3.7 259 Caucasian Americans 12589394
BDNF met66val met/val NEO PI Vulnerability 11.08 4.33 162 Caucasian Americans 12589394
BDNF met66val met/met NEO PI Vulnerability 9.00 3.13 20 Caucasian Americans 12589394
BDNF met66val val/val NEO PI Feelings 20.90 3.82 254 Caucasian Americans 12589394
BDNF met66val met/val NEO PI Feelings 19.78 3.55 161 Caucasian Americans 12589394
BDNF met66val met/met NEO PI Feelings 19.92 3.71 20 Caucasian Americans 12589394

[edit] Critique

  1. Standard error of mean (in Table 2) is wrong for Self-consciousness
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