A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women

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A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women
Authors: Jonas Melke, Lars Westberg, Staffan Nilsson, Mikael Landen, Henrik Soderstrom, Fariba Baghaei, Roland Rosmond, Goran Holm, Per Bjorntorp, Lars-Goran Nilsson, Rolf Adolfsson, Elias Eriksson
Citation: Archives of general psychiatry 60 (10): 1017-1013. 2003 October
Database(s): PubMed (PMID/14557147)
DOI: 10.1001/archpsyc.60.10.1017.
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Extract:

A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women reports a personality genetics study on the HTR3A C178T and A1596G genetic polymorphism and personality traits assessed with the Temperament and Character Inventory and Karolinska Scales of Personality.

[edit] Subjects

Subject group #1 (help)
Swedish women from Gothenburg
Subjects/♂/♀: 194 / 0 / 194
Age: 42 (42–42)
Nationality: Swedish
Approval: Ethics committees of Göteborg University and Umeå University
Databases:

Group 1 of 194 swedish women from Gothenburg with 0 males and 194 females were included in the study. The Swedish group had a mean age of 42 with a range from 42 to 42.

The study on the human subjects was approved by the Ethics committees of Göteborg University and Umeå University.
Subject group #2 (help)
Swedish women from Umeå
Subjects/♂/♀: 171 / 0 / 171
Age: (35–45)
Nationality: Swedish
Approval: Ethics committees of Göteborg University and Umeå University
Databases:

Group 2 of 171 swedish women from Umeå with 0 males and 171 females were included in the study. The Swedish group was from 35 up to 45 years old. The study on the human subjects was approved by the Ethics committees of Göteborg University and Umeå University.

Subject group 1 completed both TCI (191 subjects) and KSP (194 subjects). Subject group 2 completed only TCI.

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
HTR3A C178T C/C TCI Novelty seeking 21.1 5.0 121 Swedish women from Gothenburg 14557147
HTR3A C178T C/T TCI Novelty seeking 20.8 5.1 64 Swedish women from Gothenburg 14557147
HTR3A C178T T/T TCI Novelty seeking 21.0 7.0 6 Swedish women from Gothenburg 14557147
HTR3A C178T C/C TCI Harm avoidance 15.3 6.8 121 Swedish women from Gothenburg 14557147
HTR3A C178T C/T TCI Harm avoidance 16.6 6.3 64 Swedish women from Gothenburg 14557147
HTR3A C178T T/T TCI Harm avoidance 7.8 8.3 6 Swedish women from Gothenburg 14557147
HTR3A C178T C/C TCI Reward dependence 15.7 3.5 121 Swedish women from Gothenburg 14557147
HTR3A C178T C/T TCI Reward dependence 15.2 3.3 64 Swedish women from Gothenburg 14557147
HTR3A C178T T/T TCI Reward dependence 16.8 3.5 6 Swedish women from Gothenburg 14557147
HTR3A C178T C/C TCI Persistence 3.7 1.8 121 Swedish women from Gothenburg 14557147
HTR3A C178T C/T TCI Persistence 3.7 1.7 64 Swedish women from Gothenburg 14557147
HTR3A C178T T/T TCI Persistence 4.3 1.9 6 Swedish women from Gothenburg 14557147
HTR3A C178T C/C TCI Novelty seeking 20.3 5.6 111 Swedish women from Umea 14557147
HTR3A C178T C/T TCI Novelty seeking 20.2 5.5 57 Swedish women from Umea 14557147
HTR3A C178T T/T TCI Novelty seeking 23.4 6.9 7 Swedish women from Umea 14557147
HTR3A C178T C/C TCI Harm avoidance 15.2 5.8 111 Swedish women from Umea 14557147
HTR3A C178T C/T TCI Harm avoidance 14.3 6.0 57 Swedish women from Umea 14557147
HTR3A C178T T/T TCI Harm avoidance 8.8 3.1 7 Swedish women from Umea 14557147
HTR3A C178T C/C TCI Reward dependence 16.8 3.1 111 Swedish women from Umea 14557147
HTR3A C178T C/T TCI Reward dependence 16.9 3.9 57 Swedish women from Umea 14557147
HTR3A C178T T/T TCI Reward dependence 16.0 2.9 7 Swedish women from Umea 14557147
HTR3A C178T C/C TCI Persistence 4.0 1.8 111 Swedish women from Umea 14557147
HTR3A C178T C/T TCI Persistence 4.2 2.2 57 Swedish women from Umea 14557147
HTR3A C178T T/T TCI Persistence 3.6 1.4 7 Swedish women from Umea 14557147
HTR3A C178T C/C KSP Extraversion 51.5 7.5 122 Swedish women from Gothenburg 14557147
HTR3A C178T C/T KSP Extraversion 52.6 8.2 63 Swedish women from Gothenburg 14557147
HTR3A C178T T/T KSP Extraversion 56.8 11.8 6 Swedish women from Gothenburg 14557147
HTR3A C178T C/C KSP Neuroticism 47.9 7.4 114 Swedish women from Gothenburg 14557147
HTR3A C178T C/T KSP Neuroticism 49.6 7.2 58 Swedish women from Gothenburg 14557147
HTR3A C178T T/T KSP Neuroticism 44.6 8.4 5 Swedish women from Gothenburg 14557147
HTR3A C178T C/C KSP Psychoticism 48.0 8.7 119 Swedish women from Gothenburg 14557147
HTR3A C178T C/T KSP Psychoticism 48.7 10.1 63 Swedish women from Gothenburg 14557147
HTR3A C178T T/T KSP Psychoticism 44.3 14.2 6 Swedish women from Gothenburg 14557147
HTR3A C178T C/C KSP Nonconformity 50.0 7.5 119 Swedish women from Gothenburg 14557147
HTR3A C178T C/T KSP Nonconformity 52.1 5.2 62 Swedish women from Gothenburg 14557147
HTR3A C178T T/T KSP Nonconformity 39.8 7.1 6 Swedish women from Gothenburg 14557147
HTR3A C178T C/C KSP Social desirability 47.2 8.8 119 Swedish women from Gothenburg 14557147
HTR3A C178T C/T KSP Social desirability 46.4 6.6 62 Swedish women from Gothenburg 14557147
HTR3A C178T T/T KSP Social desirability 58.0 12.9 6 Swedish women from Gothenburg 14557147
HTR3A C178T C/C KSP Indirect aggression 53.4 11.5 119 Swedish women from Gothenburg 14557147
HTR3A C178T C/T KSP Indirect aggression 55.6 9.5 62 Swedish women from Gothenburg 14557147
HTR3A C178T T/T KSP Indirect aggression 40.6 14.3 6 Swedish women from Gothenburg 14557147
HTR3A C178T C/C KSP Verbal aggression 48.1 9.2 119 Swedish women from Gothenburg 14557147
HTR3A C178T C/T KSP Verbal aggression 51.7 9.3 62 Swedish women from Gothenburg 14557147
HTR3A C178T T/T KSP Verbal aggression 42.9 7.9 6 Swedish women from Gothenburg 14557147
HTR3A C178T C/C KSP Irritability 45.6 9.0 119 Swedish women from Gothenburg 14557147
HTR3A C178T C/T KSP Irritability 47.5 7.7 62 Swedish women from Gothenburg 14557147
HTR3A C178T T/T KSP Irritability 33.7 8.6 6 Swedish women from Gothenburg 14557147

[edit] Critique

  1. Bias reporting: Two polymorphisms were examined but only personality scores from the significant polymorphism were given.
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